Category: 40230-24-8

Synthesis and Antimicrobial Activity of Azolyl Pyrimidines was written by Butta, Ragavendra;Donthamsetty V, Sowmya;Adivireddy, Padmaja;Venkatapuram, Padmavathi. And the article was included in Journal of Heterocyclic Chemistry in 2017.Quality Control of 4,6-Diphenylpyrimidin-2-amine This article mentions the following:

A new class of azolyl pyrimidines I (X = O, S, NH; R = C₆H₅, 4-H₃CC₆H₄, 4-ClC₆H₄, 4-BrC₆H₄, 4-O₂NC₆H₄) linked by diamino sulfone moiety was prepared and their antimicrobial activity was studied. Chloro-substituted and nitro-substituted thiazolyl pyrimidines I (X = S; R = 4-ClC₆H₄ and 4-O₂NC₆H₄) showed excellent antibacterial activity against Bacillus subtilis, while imidazolyl pyrimidines I (X = NH; R = 4-ClC₆H₄ and 4-O₂NC₆H₄) exhibited promising antifungal activity against Aspergillus niger. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Quality Control of 4,6-Diphenylpyrimidin-2-amine).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Quality Control of 4,6-Diphenylpyrimidin-2-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidino piperazinyl acetamides: innovative class of hybrid acetamide drugs as potent antimicrobial and antimycobacterial agents was written by Kanagarajan, V.;Gopalakrishnan, M.. And the article was included in Pharmaceutical Chemistry Journal in 2012.Computed Properties of C16H13N3 This article mentions the following:

New 2-(4-methylpiperazin-1-yl)-N-(4,6-diarylpyrimidin-2-yl)acetamides (34-42) have been synthesized and tested for their in vitro antimicrobial and antimycobacterial properties. Compounds 34, 39 against S. aureus, 39 against 尾-hemolytic Streptococcus, 42 against V. cholerae, 40-42 against E. coli, 38, 39 against K. pneumoniae, and 37-41 against P. aeruginosa showed excellent antibacterial activity by inhibiting the growth of the resp. organisms at a min. inhibitory concentration of 6.25 渭g/mL. Noteworthy compounds 40 against A. flavus, 34 against M. indicus, 40, 42 against R. arrhizus and M. gypseum also exhibited excellent antifungal activity by inhibiting the growth of these microorganisms, at a min. inhibitory concentration of 6.25 渭g/mL. Moreover, compounds 36, 38, and 40-42 showed promising antitubercular activity by inhibiting the growth of M. tuberculosis H 37 Rv and clin. isolated isoniazid-resistant M. tuberculosis strains. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Computed Properties of C16H13N3).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Computed Properties of C16H13N3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthesis and characterization of new trifluoromethyl substituted 3-ethoxycarbonyl- and 3-pyrimidin-2-yl-(1,2,3)-oxathiazinane-S-oxides was written by Zanatta, Nilo;Borchhardt, Deise M.;Flores, Darlene C.;Coelho, Helena S.;Marchi, Tiago M.;Flores, Alex F. C.;Bonacorso, Helio G.;Martins, Marcos A. P.. And the article was included in Journal of Heterocyclic Chemistry in 2008.Related Products of 40230-24-8 This article mentions the following:

This paper describes the synthesis and characterization of a new series of 4-substituted 3-ethoxycarbonyl- and 3-(4,6-diphenylpyrimidin-2-yl)-6-trifluoromethyl-(1,2,3)oxathiazinane S-oxides by cyclization of 4,4,4-trifluoro-3-hydroxybutylcarbamates and 4-(4,6-diphenylpyrimidin-2-ylamino)-1,1,1-trifluorobutan-2-ols, resp., with SOCl₂. The anal. of the NMR data allowed us to define important features of the mol. structure. Significant chem. and structural differences were observed between the trifluoromethylated oxathiazinanes obtained in this work from other analogous compounds reported in the literature. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Related Products of 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Related Products of 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine reactions. XXIV. Dehalogenation of 2-halopyrimidines by hydriodic acid was written by Brown, D. J.;Waring, P.. And the article was included in Australian Journal of Chemistry in 1973.Computed Properties of C16H13N3 This article mentions the following:

2-Halopyrimidines underwent dehalogenation conveniently on treatment with hot HI to give the pyrimidines (I; R1 = H, R = R2 = Me, Ph; R = R2 = H, R1 = Me; R1 = R2 = H, R = Me). Unsubstituted pyrimidine was obtained similarly from its 2-chloro-, 2-bromo, or 2-iodo derivative, the last was made in a pure state for the first time. 4-Chloro-2,6-dimethylpyrimidine underwent hydrolysis in hot HI, and transhalogenation to give its 4-iodo analog at lower temperatures; both 2-chloro-4-methoxypyrimidine and 5-chlorouracil gave uracil with hot HI and 4-chloro-2,6-dimethoxypyrimidine gave 6-iodouracil under similar conditions. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Computed Properties of C16H13N3).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Computed Properties of C16H13N3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Oxalic acid catalysed chromium(VI) oxidation of some 2-amino-4,6-diarylpyrimidines was written by Meenakshisundaram, S. P.;Gopalakrishnan, M.;Nagarajan, S.;Sarathi, N.. And the article was included in Catalysis Communications in 2007.SDS of cas: 40230-24-8 This article mentions the following:

Some 2-amino-4,6-diarylpyrimidines (APM), synthesized from chalcones and guanidine hydrochloride in presence of alkali by microwave irradiation in solvent-free conditions, were subjected to oxidation with chromium(VI)-oxalic acid complex (Cr(VI)-Oxa) in highly acidic solutions Oxalic acid (Oxa) offers the reaction a more favorable pathway and in the absence of oxalic acid the reaction is sluggish. The depletion of chromium(VI) shows a complicated kinetics involving a fast reaction to about 35% consumption followed by a slow one. Low dielec. constant of the medium facilitates the reaction. The investigations with 2-amino-6-(4-nitrophenyl)- 4-phenylpyrimidine and 2-amino-6-(4-methoxyphenyl)-4-phenylpyrimidine reveal that, irresp. of the nature of the substituents, the rates are higher than for the parent. APM is catalytically converted to the unusual product 3-hydroxy-1,3-diphenyl-propan-1-one. Consideration of the kinetic behaviors under different exptl. conditions and the product assignment provide valuable mechanistic insight into the system studied. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8SDS of cas: 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.SDS of cas: 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Preparation of heterocycles by the reaction of diaza binucleophiles with chalcones: influence of the substituent on position 2 was written by Simon, Dominique;Lafont, Olivier;Farnoux, Claude Combet;Miocque, Marcel. And the article was included in Journal of Heterocyclic Chemistry in 1985.COA of Formula: C16H13N3 This article mentions the following:

The reaction of PhCH:CRCOPh (R = Br, NET₂, OPh, Bz, SPh, NO₂, H) with R¹NHNH₂ gave various hydrazine derivatives or the pyrazoles I or pyrazolines II. Reaction with thiourea or guanidine gave the pyrimidines III and IV (R = H, OPh, SPh). In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8COA of Formula: C16H13N3).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.COA of Formula: C16H13N3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

A simple and highly efficient synthesis of novel fluorinated 4,6-disubstituted aminopyrimidines using Cd(OAc)₂ was written by Kumar, Amit;Kumari, Poonam;Bhagat, Sunita. And the article was included in Synthetic Communications in 2020.Related Products of 40230-24-8 This article mentions the following:

A highly efficient fluorination reaction of 4,6-disubstituted aminopyrimidines I (R¹ = C₆H₅, 4-ClC₆H₄, 4-BrC₆H₄, 4-FC₆H₄, 2-thienyl; R² = H, OMe, F, Cl, Br, Me; X = H) using N-Fluorobenzenesulfonimide (NFSI) has been developed, presumably proceeding via C-H bond activation. Cadmium acetate was employed as the salts, and various fluorinated 4,6-disubstituted aminopyrimidines I (X = F) have been generated in good to excellent yields. This chem. endows an economical method of valuable fluorinated 4,6-disubstituted aminopyrimidines I (X = F) through a direct C-F bond formation. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Related Products of 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Related Products of 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthesis and in vitro microbiological evaluation of an array of biolabile 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides was written by Kanagarajan, V.;Thanusu, J.;Gopalakrishnan, M.. And the article was included in European Journal of Medicinal Chemistry in 2010.Formula: C16H13N3 This article mentions the following:

Biolabile 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides I (R¹ = H, F, Me; R² = H, F, MeO) were synthesized and evaluated for their in vitro antibacterial and antifungal activities. The min. inhibitory concentration tested against the same set of bacterial and fungal strains showed that I (R¹ = F, R² = H) against β-Hemolytic streptococcus and Klebsiella pneumoniae and I (R¹ = R² = F) against Escherichia coli and Pseudomonas had excellent antibacterial activity. Compounds I (R¹ = F, R² = H, MeO) showed inhibition against Aspergillus flavus, I (R¹ = Me, R² = F) against Microsporum gypseum, I (R¹ = F, R² = MeO) against Mucor, and compounds I (R¹ = Me, R² = MeO; R¹ = R² = F) against Rhizopus. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Formula: C16H13N3).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Formula: C16H13N3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Metal-free cascade synthesis of unsymmetrical 2-aminopyrimidines from imidazolate enaminones was written by Cui, Xue;Ma, Jianting;Zeng, Tingting;Xu, Junyu;Li, Youbin;Wang, Xuesong. And the article was included in RSC Advances in 2021.Application of 40230-24-8 This article mentions the following:

A convenient metal-free synthesis of unsym. 2-aminopyrimidines I [R¹ = cyclopropyl, Ph, 4-MeC₆H₄, etc.; R² = Ph, 4-ClC₆H₄, 4-MeOC₆H₄, etc.] from imidazolate enaminones had been developed. In this procedure, various structural 2-aminopyrimidines I, as well as 4,5-dihydroisoxazol-5-ols and pyrazoles were synthesized in moderate to excellent yields. A plausible mechanism was also proposed for the cascade reaction. This method represented an effective strategy toward the synthesis of unsym. 2-aminopyrimidines I. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Application of 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Application of 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

One-pot synthesis and in vitro microbiological evaluation of pyrimidinyl thiazolidinones catalyzed by activated fly ash in dry media was written by Kanagarajan, V.;Gopalakrishnan, M.. And the article was included in Pharmaceutical Chemistry Journal in 2010.Recommanded Product: 40230-24-8 This article mentions the following:

Novel bioactive 2-phenyl-3-(4,6-diarylpyrimidin-2-yl)thiazolidin-4-ones were synthesized with good yields in a short reaction time by 1-pot multicomponent reaction of 2-amino-4,6-diarylpyrimidines, PhCHO, and thioglycolate under microwave irradiation in the presence of an activated fly ash catalyst in dry medium. The characterization of these compounds was performed by m.p., elemental anal., mass spectra, FT-IR, and ¹H and ¹³C NMR. In search for new leads toward potent antimicrobial agents, all the synthesized compounds were tested in vitro for their antibacterial activity against Bacillus subtilis and Micrococcus luteus and antifungal activity against Aspergillus niger, Candida albicans, Candida 6, and Candida 51, and the results were discussed. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Recommanded Product: 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Recommanded Product: 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia