Category: 40497-30-1

Reference of 40497-30-1 ,Some common heterocyclic compound, 40497-30-1, molecular formula is C5H6N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Preparation of 1,1-diamino-2,2-dinitroethylene from the nitric-sulfur mixed acid prepared from the nitric acid filtrate once recycledAt 20C, weigh 62.5g of the nitric acid filtrate once cycled, add 25.0g of fuming sulfuric acid with a mass fraction of 50% and 62.5g of nitric acid with a mass fraction of 98% in order to obtain 150.0g of mixed nitric acid;The nitric-sulfur mixed acid was cooled to 0 C, and 10.0 g of 2-methyl-4,6-pyrimidinedione was added in portions with stirring.Then warmed to 15C for 3h,After the reaction, the temperature was reduced to 0C, and the nitric acid filtrate was collected. The filter cake was added to 450 g of ice water. After filtering and drying, 10.2 g of 1,1-diamino-2,2-dinitroethylene was obtained, and the yield was 86.8%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,40497-30-1, its application will become more common.

Reference:
Patent; Xi’an Modern Chemical Institute; Zhou Cheng; Li Xiangzhi; Chang Pei; Wang Bozhou; Zhou Qun; Chen Tao; Li Yanan; (6 pag.)CN107602395; (2019); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 40497-30-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 40497-30-1, name is 2-Methylpyrimidine-4,6(1H,5H)-dione. A new synthetic method of this compound is introduced below.

4,6-dichloro-2-methylpyrimidine (1.63 g, 10.0 mmol) prepared based on the method described in Production Example 2A above using 2-methyl-1H-pyrimidine-4,6-dione instead of the 2-ethyl-1H-pyrimidine-4,6-dione, was slowly added to a 2-ethoxyethanol (5.0 mL) solution of 3-aminophenol (1.09 g, 10.0 mmol) and the reaction mixture heated for 4 hours at 130C. The reaction was monitored by thin layer chromatography and, following the end of the reaction, the reaction mixture was cooled to room temperature and the precipitated white powder filtered off. The crude product filtered off was used in the subsequent reaction without further purification (1.76 g, crude yield 75%).1H NMR spectrum (DMSO, 400 MHz), delta : 2.42(3H, s), 6.50(1H, m), 6.73(1H, s), 7.05(1H, m), 7.12(1H, m), 7.19(1H, s), 10.00(1H, s). Mass spectrum (EI), m/z: 234 (M-H+)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,40497-30-1, its application will become more common.

Reference:
Patent; Sankyo Company, Limited; EP1473289; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 40497-30-1, name is 2-Methylpyrimidine-4,6(1H,5H)-dione. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 40497-30-1

FOX-7 was synthesized according to the method using the procedure of Fu [9]. 2-methylpyrimidine-4,6-dione (2.53 g,0.02 mol) was dissolved in 12mL concentrated H2SO4 (98%), and then 4mL Nitric acid fuming (98%) was dripped in the mixture. The reaction mixture was kept under 15C. After 3 h, the mixture was poured into ice water. The yellow precipitate formed, which was filtered and dried 5 h under vacuum at 50C, yielding 2.40 g (81.1%).The yellow crystal was obtained from C2H5OH solvent. IR (KBr,nu /cm-1): 3407, 3321, 3294, 3216, 1622, 1501, 1473, 1388, 1328, 1201,1161, 1133, 1020, 620, 453 cm-1.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 40497-30-1, 2-Methylpyrimidine-4,6(1H,5H)-dione.

Reference:
Article; Li, Keyao; Ren, Xiangwen; Fu, Shuqin; Zhu, Jiaping; Journal of Molecular Structure; vol. 1173; (2018); p. 26 – 32;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia