Category: 40805-79-6

Synthetic Route of 40805-79-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 40805-79-6, name is 5-Pyrimidinecarbonitrile, molecular formula is C5H3N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

3-Bromo-pyridine (0.92 ml; 9.51 mmol; 2.00 eq.) and anhydrous THF (8 mL) are added in a dry flask. The solution is purged with nitrogen for 30 min. Isopropylmagnesium chloride/LiCI solution 1 .3 M in THF (7.32 mL; 9.51 mmol; 2.00 eq.) is added dropwise to the reaction flask over a period of 10 min, and the mixture is stirred for 4 h at RT. The resulting solution of 3- pyridylmagnesium bromide is treated with solid pyrimidine-5-carbonitrile (0.50 g; 4.76 mmol; 1.00 eq.) at RT and to the resulting mixture NaBH4 (0.72 g; 19.03 mmol; 4.00 eq.) is added, followed by water (0.2 mL, after 30 minutes) The mixture is stirred overnight. Next portion of water (10 mL) is added and the mixture concentrated in vacuo. The residue is dissolved in EtOAc and filtered. Oily residue is purified by FCC (DCM/MeOH; gradient) provided C- pyridin-3-yl-C-pyrimidin-5-yl-methylamine (100.00 mg; yield 1 1.3 %; yellow oil).

According to the analysis of related databases, 40805-79-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SELVITA S.A.; FABRITIUS, Charles-Henry Robert Yves; NOWAK, Mateusz Oktawian; WIKLIK, Katarzyna Anna; SABINIARZ, Aleksandra Barbara; BIE?, Marcin Dominik; BUDA, Anna Ma?gorzata; GUZIK, Pawel Szczepan; JAKUBIEC, Krzysztof Roman; MACIUSZEK, Monika; KWIECI?SKA, Katarzyna; TOMCZYK, Mateusz Micha?; GA??ZOWSKI, Micha? Miko?aj; GONDELA, Andrzej; DUDEK, ?ukasz Piotr; (681 pag.)WO2016/180536; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 40805-79-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 40805-79-6, name is 5-Pyrimidinecarbonitrile. This compound has unique chemical properties. The synthetic route is as follows.

In a 250 mL round-bottomed flask, pyrimidine-5-carbonitrile (1.5 g, 14.3 mmol), pyridine (0.339 g, 0.35 ml, 28.5 mmol), and 2-mercaptopropionic acid (1.51 g, 14.3 mmol) were combined to give a light yellow solution. The reaction mixture was heated to 100 C. and stirred for 2 h. Upon cooling, the thick yellow mixture was diluted with 100 mL ethanol and stirred for 30 min. The slurry was then filtered, and washed with diethyl ether (2*100 mL) to give 5-Methyl-2-(pyrimidin-2-yl)-thiazol-4-ol (2.33 g, 85%) as yellow solid which was used directly without further purification.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 40805-79-6, 5-Pyrimidinecarbonitrile.

Reference:
Patent; Alam, Muzaffar; Du Bois, Daisy Joe; Hawley, Ronald Charles; Kennedy-Smith, Joshua; Minatti, Ana Elena; Palmer, Wylie Solang; Silva, Tania; Wilhelm, Robert Stephen; US2011/71150; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia