Synthetic Route of 4214-57-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4214-57-7, name is 2-Amino-5-bromo-4,6-dimethylpyrimidine. A new synthetic method of this compound is introduced below.
To a stirred solution containing 2.00 g (9.89 mmol) of 2-amino-5-bromo-4,6-dimethylpyrimidine (5) in 16 mL of toluene was added 1.36 mL (1.32 g; 11.5 mmol) of 2,5-hexanedione followed by 96 mg (0.50 mmol) of p-toluenesulfonic acid. The reaction mixture was heated and stirred at reflux for 12 h. The reaction mixture was poured into 150 mL of water and then extracted with 200 mL of ethyl acetate. The organic solution was washed with 150 mL of brine, dried (MgSO4) and concentrated under diminished pressure. The residue was purified by chromatography on a silica gel column (15 * 5 cm). Elution with 5:1 hexanes/ethyl acetate afforded 6 as light yellow crystals: yield 2.23 g (81%); mp 64-65 C; silica gel TLC Rf 0.65 (6:1 hexanes/ethyl acetate); 1H NMR (CDCl3) delta 2.34 (s, 6H), 2.67 (s, 6H) and 5.89 (s, 2H); 13C NMR (CDCl3) delta 14.5, 24.9, 108.7, 118.6, 129.5, 155.3 and 166.9; mass spectrum (APCI), m/z 280.0458 (M+H)+ (C12H15N3Br requires 280.0449).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,4214-57-7, 2-Amino-5-bromo-4,6-dimethylpyrimidine, and friends who are interested can also refer to it.
Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia