Category: 425394-89-4

Adding a certain compound to certain chemical reactions, such as: 425394-89-4, 4,6-Dichloropyrimidin-5-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 4,6-Dichloropyrimidin-5-ol, blongs to pyrimidines compound. Application In Synthesis of 4,6-Dichloropyrimidin-5-ol

To a solution of tert-butyl (trans-4-(hydroxymethyl)cyclohexyl)carbamate (0.84 g, 3.65 mmol) in THF (15 mL) was added No.23 triphenylphosphine (1.43 g, 5.45 mmol) and No.23 4,6-dichloropyrimidin-5-ol (0.68 g, 3.65 mmol). To the mixture was added No.23 diisopropylazodicarboxylate (1.47 g, 7.27 mmol) at 0C., the mixture was stirred at room temperature for 18 hr. The reaction mixture was concentrated in vacuo and the residue was purified by column chromatography on silica gel (hexane:ethyl acetate=40:1 as eluent) to afford the tert-butyl (trans-4-(((4,6-dichloropyrimidin-5-yl)oxy)methyl)cyclohexyl)carbamate as colorless oil (0.45 g, 33% yield). LC/MS APCI: Calculated 375.11; Observed m/z [M-99 (boc)]+ 276.1. 1H-NMR 400 MHz, DMSO-d6: delta 8.68 (s, 1H), 6.75 (d, J=7.60 Hz, 1H), 3.94 (d, J=6.00 Hz, 2H), 3.16-3.14 (m, 1H), 1.89-1.79 (m, 4H), 1.73-1.71 (m, 1H), 1.38 (s, 9H), 1.19-1.16 (m, 4H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,425394-89-4, 4,6-Dichloropyrimidin-5-ol, and friends who are interested can also refer to it.

Reference:
Patent; Arrien Pharmaceuticals LLC; Vankayalapati, Hariprasad; US2020/131154; (2020); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 425394-89-4, name is 4,6-Dichloropyrimidin-5-ol, the common compound, a new synthetic route is introduced below. HPLC of Formula: C4H2Cl2N2O

(1) 5-(Benzyloxy)-4,6-dichloropyrimidine, INT 45 To a solution of INT 37 (content 90%, 6.50 g, 35.50 mmol) in DMF (120 mL) was added benzyl bromide (8.42 mL, 70.90 mmol) followed by potassium carbonate (14.70 g, 106.36 mmol). The reaction mixture was stirred at 60 C. for 1 hr. The mixture was concentrated. The residue was partitioned between EtOAc and water. The organic layer was washed with water and brine, dried over magnesium sulfate, filtered and concentrated. The residue was purified by flash chromatography (silica; cyclohexane/EtOAc gradient, 0-10%) to afford INT 45 as a colorless oil. UPLC-MS: MS (ESI): [M+H]+ 255.1, rt=1.15 min. 1H NMR (DMSO-d6): delta (ppm) 8.72 (s, 1H), 7.57-7.50 (m, 2H), 7.48-7.37 (m, 3H), 5.19 (s, 2H).

The synthetic route of 425394-89-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NOVARTIS AG; ANGST, Daniela; GESSIER, Francois; VULPETTI, Anna; US2015/152068; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 425394-89-4 , The common heterocyclic compound, 425394-89-4, name is 4,6-Dichloropyrimidin-5-ol, molecular formula is C4H2Cl2N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of No.31 4-(hydroxymethyl)cyclohexan-1-ol (0.237 g, 1.82 mmol) in No.13 THF (15 mL) was added No.23 triphenylphosphine (0.718 g, 2.74 mmol) and No.23 4,6-Dichloropyrimidin-5-ol (0.3 g, 1.82 mmol). To the mixture was added No.31 di-tert-butyl azodicarboxylate (0.63 g, 2.74 mmol) at 0C., the mixture was stirred at room temperature for 18 hr. The reaction mixture was concentrated in vacuo. The residue was purified by column chromatography on silica gel (hexane:ethyl acetate=9:1 as eluent) to afford the 4-(((4,6-dichloropyrimidin-5-yl)oxy)methyl)cyclohexan-1-ol (0.15 g, 30% yield). LC/MS APCI: Calculated 276.04; Observed m/z [M+H)]+ 277.0.

The synthetic route of 425394-89-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Arrien Pharmaceuticals LLC; Vankayalapati, Hariprasad; US2020/131154; (2020); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia