Reference of 4271-96-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4271-96-9, name is 1,2-Dimethyl-1,4,5,6-tetrahydropyrimidine. A new synthetic method of this compound is introduced below.
General procedure: A solution of 55% aqueous hydroiodic acid (1 mL, ca. 7.3 mmol) was added dropwise over 1 min to a stirred mixture of amidine (1a-e, 4 mmol) or amine (1f-j, 4 mmol) in dioxane (8 mL) at 0 C. After the mixture was stirred at room temperature for 12 h, the mixture was evaporated in vacuo. The residue was washed with ether/THF (1:1 or 1:0), and the precipitate was dried in vacuo for 12 h at 50 C (1i?HI and 1j?HI were dried for 6 h at 30 C) to give corresponding hydroiodides (1a-j?HI).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4271-96-9, its application will become more common.
Reference:
Article; Aoyagi, Naoto; Furusho, Yoshio; Endo, Takeshi; Tetrahedron; vol. 75; 52; (2019);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia