Synthetic Route of 42821-92-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 42821-92-1, name is Methyl 2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate. This compound has unique chemical properties. The synthetic route is as follows.
EXAMPLE 94 In 60 ml. of water is suspended methyl 1,2,3,4-tetrahydro-2,4-dioxopyrimidine-5-carboxylate (2.55 g., 15.0 mmoles) and, under intense stirring at room temperature, chlorine gas is bubbled into the suspension. The reaction is complete when the solid has dissolved. Following addition of 10 ml. of concentrated hydrochloric acid, the reaction mixture is refluxed for 16 hours. It is then concentrated under reduced pressure to one-fifth of its initial volume to give 1.39 g. of 5-chlorouracil as pale yellow needles. Melting Point: above 300 C. UV spectrum: lambdamaxpH 1.0 274 nm, lambdamaxpH 7.0 275 nm. NMR spectrum (DMSO-d6) delta: 7.75(1H, d, J=6HZ), 11.17(1H, broad), 11.48(1H, broad). Elemental analysis, for C4 H3 ClN2 O2: Calcd.: C, 32.78; H, 2.06; N, 19.12; Cl, 24.20. Found: C, 32.54; H, 1.97; N, 19.02; Cl, 24.30.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 42821-92-1, Methyl 2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate.
Reference:
Patent; Takeda Chemical Industries, Ltd.; US4329460; (1982); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia