Category: 42839-08-7

Venkat Ragavan, R. published the artcileSimple, fast and efficient synthesis of β-keto esters from the esters of heteroaryl compounds, its antimicrobial study and cytotoxicity towards various cancer cell lines, Safety of Ethyl pyrimidine-2-carboxylate, the main research area is heteroaryl keto ester preparation antimicrobial anticancer activity.

A series of β-keto esters were synthesized from heteroaryl esters and Et acetate using LiHMDS as base at -50 to -30 °C. Increases in yields of cross-condensed products were observed and the percentage of self-condensed product was reduced drastically by applying the suitable base (LiHMDS), solvent, and a min. amount of Et acetate. All these β-keto esters were characterized using 1H NMR, 13C NMR and mass spectral data. A plausible mechanism is also depicted to prove the formation of trans-esterified products. All the synthesized compounds were tested for their cytotoxicity towards various cancer cell lines and also tested for their antimicrobial activity towards various bacterial and fungal strains and some of them were found to have promising activity.

Bioorganic & Medicinal Chemistry Letters published new progress about Antibacterial agents. 42839-08-7 belongs to class pyrimidines, name is Ethyl pyrimidine-2-carboxylate, and the molecular formula is C7H8N2O2, Safety of Ethyl pyrimidine-2-carboxylate.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Heinisch, Gottfried published the artcileNovel diazinyl 3-pyridyl ketones: efficient synthesis and complete assignment of 1H and 13C NMR spectra, SDS of cas: 42839-08-7, the main research area is diazinyl pyridyl ketone preparation NMR.

The preparation of six diazinyl 3-pyridyl ketones is described: 3-pyridyl 3-pyridazinyl ketone, 3-pyridyl 4-pyridazinyl ketone, 3-pyridyl 2-pyrimidinyl ketone, 3-pyridyl 4-pyrimidinyl ketone, 3-pyridyl 5-pyrimidinyl ketone, and 3-pyridyl 2-pyrazinyl ketone. Detailed 1H NMR data of these novel building blocks are given.

Journal of Heterocyclic Chemistry published new progress about Ketones Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 42839-08-7 belongs to class pyrimidines, name is Ethyl pyrimidine-2-carboxylate, and the molecular formula is C7H8N2O2, SDS of cas: 42839-08-7.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Yamagami, Chisako published the artcileHydrophobicity parameter of diazines IV: a new hydrogen-accepting parameter of monosubstituted (di)azines for the relationship of partition coefficients in different solvent systems, Application of Ethyl pyrimidine-2-carboxylate, the main research area is hydrophobicity diazine hydrogen accepting parameter scale; monosubstituted azine partition solvent effect LFER hydrophobicity.

The authors recently proposed a new H-accepting scale, SHA, for each member of the substituted (di)azine series from the heat of formation calculated under various dielec. environments by the COSMO method. The SHA scale was used to examine relations between log PCL (PCL: CHCl3/H2O partition coefficient) and log Poct (Poct: 1-octanol/H2O partition coefficient) for each of the 2-substituted pyridine (I), monosubstituted pyrazine (II), and pyrimidine (III) series. This SHA parameter worked nicely, representing the H-accepting effect of the solute mol. A correlation equation with excellent quality, such as log PCL = a log Poct + sSHA + constant, was obtained for each series. The authors further defined the parameter SHA/PY, derived from SHA values for the heterocyclic series by shifting the reference points to unsubstituted pyridine, to unify sep. derived correlation equations. Thus, the correlation between log PCL and log Poct for all combined data of three series was derived by using a single equation as log PCL = a log Poct + sSHA/PY + constant The SHA parameters were reasonably considered as being free-energy related, and the rationale for the H-bond-acceptor scale was presented.

Journal of Pharmaceutical Sciences published new progress about Correlation analysis. 42839-08-7 belongs to class pyrimidines, name is Ethyl pyrimidine-2-carboxylate, and the molecular formula is C7H8N2O2, Application of Ethyl pyrimidine-2-carboxylate.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Guo, Chunfang published the artcileDirect C-H Difluoroalkylation of Heteroarenes with Difluoroalkyl Carboxylic Acids, Application In Synthesis of 42839-08-7, the main research area is difluoroalkylated heteroarene preparation; heteroarene difluoroalkyl carboxylic acid CH difluoroalkylation silver catalyst.

A new method for the difluoroalkylation of heteroaromatic compounds were developed by employing readily available difluoroalkyl carboxylic acids. This silver-catalyzed reaction proceeded under mild conditions and afforded a broad range of difluoroalkylated heteroarenes RCF2Ar [R = Me, Et, CH2CH2Ph; Ar = 4-CN-2-pyridyl, 4-PhO-2-pyridyl, 4-Me-2-quinolinyl, etc.] in moderate to good yields, including pyridines, pyrimidines, pyrazines, quinolines, quinoxalines as well as bioactive compounds

Asian Journal of Organic Chemistry published new progress about Fluoroalkanes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 42839-08-7 belongs to class pyrimidines, name is Ethyl pyrimidine-2-carboxylate, and the molecular formula is C7H8N2O2, Application In Synthesis of 42839-08-7.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 42839-08-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 42839-08-7, name is Ethyl pyrimidine-2-carboxylate. A new synthetic method of this compound is introduced below.

The 2 – (2 – methoxy phenoxy) malonamide (II) (35.0 g, 156.1 mmol) dissolved in ethanol (600 ml) in, are tertiary butanol sodium (30.0 g, 312.2 mmol) and 2 – pyrimidine formic acid ethyl ester (III) (23.8 g, 156.1 mmol), stirred under the protection of nitrogen reflux 1 h, TLC detection reaction is completed. Recovering the ethanol, the residue with water (200 ml) mixed beating, filtering, a little water to wash the filter cake, drying, to obtain compound 5 – (2 – methoxyphenoxy) – 1H – [2, 2′] – bipyridyl – 4, 6 – dione (IV) 40.5 g, yield is 83%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,42839-08-7, Ethyl pyrimidine-2-carboxylate, and friends who are interested can also refer to it.

Reference:
Patent; Shanghai Tianci International Pharmaceutical Co., Ltd.; Li Xinjuanzi; Li Jianzhi; Ma Xilai; Chi Wangzhou; Liu Hai; Hu Xuhua; Zheng Xiaoli; Zhai Zhijun; Li Jianxun; (14 pag.)CN104193687; (2017); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 42839-08-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.42839-08-7, name is Ethyl pyrimidine-2-carboxylate, molecular formula is C7H8N2O2, molecular weight is 152.15, as common compound, the synthetic route is as follows.

The 2 – (2 – methoxy phenoxy) malonamide (II) (35.0 g, 156.1 mmol) dissolved in ethanol (600 ml) in, are tertiary butanol sodium (30.0 g, 312.2 mmol) and 2 – pyrimidine formic acid ethyl ester (III) (23.8 g, 156.1 mmol), stirred under the protection of nitrogen reflux 1 h, TLC detection reaction is completed. Recovering the ethanol, the residue with water (200 ml) mixed beating, filtering, a little water to wash the filter cake, drying, to obtain compound 5 – (2 – methoxyphenoxy) – 1H – [2, 2′] – bipyridyl – 4, 6 – dione (IV) 40.5 g, yield is 83%.

The chemical industry reduces the impact on the environment during synthesis 42839-08-7, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Shanghai Tianci International Pharmaceutical Co., Ltd.; Li Xinjuanzi; Li Jianzhi; Ma Xilai; Chi Wangzhou; Liu Hai; Hu Xuhua; Zheng Xiaoli; Zhai Zhijun; Li Jianxun; (14 pag.)CN104193687; (2017); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 42839-08-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 42839-08-7, name is Ethyl pyrimidine-2-carboxylate. This compound has unique chemical properties. The synthetic route is as follows.

Mg (0.48 g, 20 mmol) was added to a round-bottomed flask dried at room temperature and I2 (0.2 g) and THF (60 mL) were added under a nitrogen stream.After cooling to 01-Bromo-4-chlorobenzene (3.82 g, 20 mmol) was added slowly and the solution was stirred at room temperature for 2 hours.After cooling to 0 Ethyl pyrimidine-2-carboxylate (1.52 g, 10 mmol)Was dissolved in THF (30 mL) and slowly added to the above solution for 1 h and stirred for 2 h.After completion of the reaction, the reaction mixture was extracted with NH4Cl and ethyl acetate. The organic layer was dried over Na2SO4, concentrated under reduced pressure, and purified by column chromatography (EtOAc / Hexane)The target compound, bis(4-chlorophenyl) (pyrimidin-2-yl) methanol (1.88 g, yield 57%).

According to the analysis of related databases, 42839-08-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Doosan Co., Ltd; Lee Yong-hwan; Kim Hoe-mun; (62 pag.)KR2019/33218; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 42839-08-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.42839-08-7, name is Ethyl pyrimidine-2-carboxylate, molecular formula is C7H8N2O2, molecular weight is 152.15, as common compound, the synthetic route is as follows.

A mixture of ethyl pyrimidin-2-carboxylate (100 gm) and hydrazine hydrate (50 ml in ethanol (500 ml) was stirred at 30 C over a period of 14 h. The suspension was filtered at suction and the wet cake washed with small quantity of ethanol (25 ml) followed by diethyl ether (50 ml) to provide title compound in 80 gm quantity (88%) as a white solid.Mass: m/z: 139.0 (M+l)IH NMR: (400 Mhz, DMSO d6): 4.60 (br s, 2H, exchangeable), 7.64 (t, IH), 8.91 (d, 2H),10.00 (br s, IH, exchangeable)

The chemical industry reduces the impact on the environment during synthesis 42839-08-7, I believe this compound will play a more active role in future production and life.

Reference:
Patent; WOCKHARDT RESEARCH CENTRE; TRIVEDI, Bharat Kalidas; PATEL, Mahesh Vithalbhai; WO2010/136971; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 42839-08-7, Ethyl pyrimidine-2-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C7H8N2O2, blongs to pyrimidines compound. Formula: C7H8N2O2

Step-1: Pyrimidin-2-carboxylic acid hydrazide A mixture of ethyl pyrimidin-2-carboxylate (100 gm) and hydrazine hydrate (50 ml in ethanol (500 ml) was stirred at 30 C. over a period of 14 h. The suspension was filtered at suction and the wet cake washed with small quantity of ethanol (25 ml) followed by diethyl ether (50 ml) to provide title compound in 80 gm quantity (88%) as a white solid. Mass: m/z: 139.0 (M+1) 1H NMR: (400 Mhz, DMSO d6): 4.60 (br s, 2H, exchangeable), 7.64 (t, 1H), 8.91 (d, 2H), 10.00 (br s, 1H, exchangeable)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,42839-08-7, Ethyl pyrimidine-2-carboxylate, and friends who are interested can also refer to it.

Reference:
Patent; Trivedi, Bharat Kalidas; Patel, Mahesh Vithalbhai; US2012/142710; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 42839-08-7, Adding some certain compound to certain chemical reactions, such as: 42839-08-7, name is Ethyl pyrimidine-2-carboxylate,molecular formula is C7H8N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 42839-08-7.

General procedure: To the solution of ester (10 mmol) in THF (20 mL) and ethyl acetate (70 mmol), LiHMDS (30 mmol) was added very quickly at -40 C, and stirred at this temperature for 20 min. After completion of the reaction, reaction mixture was quenched with acetic acid (50 mmol) and then basified using 10% NaHCO3 solution, extracted with ethyl acetate (2×100 mL), the combined organic layer was washed with water and brine solution and dried over Na2SO4. The specific purification procedure for each compound has been included along with their characterization data.

According to the analysis of related databases, 42839-08-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Venkat Ragavan; Vijayakumar; Rajesh; Palakshi Reddy; Karthikeyan; Suchetha Kumari; Bioorganic and Medicinal Chemistry Letters; vol. 22; 12; (2012); p. 4193 – 4197;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia