Category: 42839-09-8

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.42839-09-8, name is 2-Pyrimidinemethanol, molecular formula is C5H6N2O, molecular weight is 110.11, as common compound, the synthetic route is as follows.Product Details of 42839-09-8

Preparation of i-2a; Step A: Preparation of pyrimidin-2-ylmethyl methanesulfonate (i-2a); Methanesulfonyl chloride (4.40 mL, 57.1 mmol) was added to a stirred solution of2-hydroxymethylpyrimidine (6.28 g, 57.1 mmol) and triethylamine (9.50 mL, 68.5 mmol) in DCM (250 mL) at 00C. After approximately 20 min, the reaction mixture was poured into water, the organic layer was separated and the aqueous phase was re-extracted twice with DCM. The combined organic extracts were washed with water, brine, dried (sodium sulfate), and concentrated in vacuo to afford the title compound i-2a. 1HNMR (500 MHz, CDCl3): delta 8.81 (d,2H, J= 4.8 Hz), 7.32 (t, IH, J= 4.9 Hz), 5.46 (s, 2H), 3.24 (s, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,42839-09-8, 2-Pyrimidinemethanol, and friends who are interested can also refer to it.

Reference:
Patent; MERCK & CO., INC.; WO2007/120574; (2007); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 42839-09-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 42839-09-8, name is 2-Pyrimidinemethanol. A new synthetic method of this compound is introduced below.

Step C: Ethyl 3-(pyrimidin-2-ylmethoxy)isonicotinate: A solution of triphenyl phosphine (14.29 g, 54.49 mmol, 1.20 equiv) in 150 ml THF was cooled to -15 C. DIAD was added via syringe (10.70 ml, 54.49 mmol, 1.20 equiv). The reaction mixture was and stirred 10 minutes at -15 C., then a solution of pyrimidin-2-ylmethanol (5.00 g, 45.41 mmol, 1.00 equiv) in 30 ml THF was added. After 10 minutes, a solution of ethyl 3-hydroxyisonicotinate (7.590 g, 45.41 mmol, 1.00 equiv) in 75 ml THF was added to the reaction mixture and the reaction mixture was allowed to warm to ambient temperature over 16 hours. The reaction was concentrated under reduced pressure and the residue was purified by silica gel chromatography to give the desired product as an oil (7.238 g, 61%). MS (APCI-pos) M+1=260.1.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,42839-09-8, 2-Pyrimidinemethanol, and friends who are interested can also refer to it.

Reference:
Patent; Miknis, Greg; Lyssikatos, Joseph P.; Laird, Ellen; Tarlton, Eugene; Buckmelter, Alexandre J.; Ren, Li; Rast, Bryson; Schlacter, Stephen T.; Wenglowsky, Steven Mark; US2007/49603; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 42839-09-8, name is 2-Pyrimidinemethanol, the common compound, a new synthetic route is introduced below. Recommanded Product: 42839-09-8

Synthesis of 2-(chloromethyl)pyrimidine:To a stirred solution of pyrimidin-2-ylmethanol (4.5 g 40.90 mmol) in DCM (50 mL) was added SOCl2 (10 mL) at 0 C under inert atmosphere. The reaction mixture was heated up to 50 C and stirred for 2 h. After completion of starting material (by TLC), the volatiles were evaporated under reduced pressure. The residue was quenched with ice cold water followed by saturated NaHC03 and extracted with EtOAc. Combined organic layer was dried over sodium sulphate, filtered and concentrated in vacuo to obtain the crude product. The crude material was purified by silica gel column chromatography to afford 2-(chloromethyl)pyrimidine (960 mg, 18%) as brown liquid. 1H-NMR (DMSO-d6, 400 MHz): delta 8.84 (d, 2H), 7.52 (t, 1H), 4.82 (s, 2H); Mass (ESI): 128.5 [M+l]; LC-MS: 95.09%; 129 (M++l) (column; Chromolith RP-18, (100×4.6 mm); RT 3.86 min. 5mM NH4OAc: ACN; 0.8 ml/min); TLC: 70% EtOAc/Hexane (Rf: 0.6).

The synthetic route of 42839-09-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ENVIVO PHARMACEUTICALS, INC.; RIPKA, Amy; SHAPIRO, Gideon; MCRINER, Andrew; WO2012/40230; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 42839-09-8, name is 2-Pyrimidinemethanol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 2-Pyrimidinemethanol

EXAMPLE 11 5-Butyl-9-[1-(2,4-dimethyl-pyridine-3-carbonyl)-4-methyl-piperidin-4-yl]-3-pyrimidin-2-ylmethyl-1-oxa-3,9-diaza-spiro[5.5]undecan-2-one (IV-5) Pyrimidin-2-ylmethyl methanesulfonate (48)-To a solution of pyrimidin-2-yl-methanol (CASRN 42839-09-8, 2 g, 1.8 mmol) and DCM (1 mL) cooled to 0 C. was added sequentially TEA (0.062 mL) and methanesulfonyl chloride (0.2 mL). The reaction mixture was stirred for 3 h then washed with aqueous NH4Cl. The solvent was removed in vacuo and residue was purified by SiO2 chromatography eluding with MeOH/DCM (1:20) to afford 0.2 g (58%) of 48. The title compound was prepared by the procedure described in steps 10-12 of example 2 except in step 10, 3-methoxy-cyclohexylmethyl tosylate was replaced with 48, and in step 12, 4,6-dimethyl-pyrimidine-5-carboxylic acid was replaced with 2,4-dimethyl-nicotinic acid. The product was purified by preparative HPLC (acetonitrile-0.01M TFA) to afford IV-5 as the trifluoroacetate salt: MS [M+]=549.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 42839-09-8, 2-Pyrimidinemethanol.

Reference:
Patent; Rotstein, David Mark; Melville, Chris Richard; US2008/249087; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 42839-09-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 42839-09-8, name is 2-Pyrimidinemethanol. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 9 A mixture of 7.2 g. of 2-pyrimidinemethanol and 25 ml. of thionyl chloride is heated for 4 hours on a steam bath, then concentrated under reduced pressure. The residue is dissolved in water and basified with 5% aqueous sodium bicarbonate solution. Extracting with ether, then drying and concentrating the extracts gives 2-(chloromethyl)pyrimidine.

According to the analysis of related databases, 42839-09-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SmithKline Corporation; US3966945; (1976); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 42839-09-8, name is 2-Pyrimidinemethanol. A new synthetic method of this compound is introduced below., Recommanded Product: 2-Pyrimidinemethanol

Also, reacting 2-hydroxymethylpyrimidine with 3-mercaptopropylamine by the procedure of Example 1 and then reacting the resulting 2-[(3-aminopropyl)thiomethyl]-pyrimidine with dimethyl-N-cyanoimidodithiocarbonate and methylamine by the procedure of Example 3(d) gives N-cyano-N’-methyl-N”-[3-(2-pyrimidylmethylthio)propyl]guanidine.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 42839-09-8, 2-Pyrimidinemethanol.

Reference:
Patent; Smith Kline & French Laboratories Limited; US3950333; (1976); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 42839-09-8, 2-Pyrimidinemethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 42839-09-8, blongs to pyrimidines compound. Product Details of 42839-09-8

(2R*, 4S*)-4-{[3, 5-Bis (trifluoromethyl) benzyl]- (5-hydroxypyrimidin-2- yl)} amino-2-ethyl-6-methoxy-3, 4-dihydro-2H- [1, 5] naphthyridine-1- carboxylic acid ethyl ester (150 mg) is dissolved in tetrahydrofuran (1 ml), then thereto are added pyrimidin-2-ylmethanol (41 mg) and triphenylphosphine (98 mg). After adding dropwise 40 % diethyl azodicarboxylate-toluene solution (163, ut) under ice-cooling, the mixture is stirred at room temperature for 1 hour and 30 minutes. Water is added to the reaction mixture and the mixture is extracted with ethyl acetate. The organic layer is washed with a saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure. The resulting residue is purified by column chromatography (silica gel; hexane: ethyl acetate = 2: 1) to give (2R*, 4S*)-4- { [3, 5-bis (trifluoromethyl) benzyl]- [5- (pyrimidin-2- ylmethoxy) pyrimidin-2-yl]} amino-2-ethyl-6-methoxy-3, 4-dihydro-2H- [1, 5] naphthyridine-l-carboxylic acid ethyl ester (118 mg). MS (m/z): 692 [M+H] +

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,42839-09-8, its application will become more common.

Reference:
Patent; TANABE SEIYAKU CO., LTD.; WO2005/95395; (2005); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia