Category: 428854-24-4

Related Products of 428854-24-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 428854-24-4, name is 2-(1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6-triamine, molecular formula is C17H15FN8, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 17A 2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-N-5-(2,2,2-trifluoroethyl)pyrimidine-4,5,6-triamine 500 mg (1.427 mmol) of the compound from example 1A were admixed with 3.5 ml of dimethylformamide and 1205 mg (4.281 mmol) of 2,2,2-trifluoroethyl trichloromethanesulfonate, and the mixture was heated at 150 C. in a microwave for 1 h. The reaction mixture was concentrated under reduced pressure, and the residue was purified by means of preparative HPLC (eluent: acetonitrile/water with 0.1% formic acid, gradient 50:50?70:30). 236 mg of the title compound were obtained (29% of theory). LC-MS (method 2): Rt=0.87 min; MS (EIpos): m/z=433 (M+H)+. 1H NMR (400 MHz, DMSO-d6): delta [ppm]=3.43-3.53 (m, 2H), 4.05 (t, 1H), 5.78 (s, 2H), 6.13 (s br, 4H) 7.10-7.15 (m, 2H), 7.20-7.25 (m, 1H), 7.32-7.38 (m, 2H), 8.60 (dd, 1H), 9.04 (dd, 1H).

According to the analysis of related databases, 428854-24-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BAYER INTELLECTUAL PROPERTY GMBH; Follmann, Markus; Stasch, Johannes-Peter; Redlich, Gorden; Ackerstaff, Jens; Griebenow, Nils; Knorr, Andreas; Wunder, Frank; Li, Volkhart Min-Jian; Baerfacker, Lars; Weigand, Stefan; US2014/148433; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 428854-24-4, 2-(1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6-triamine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 2-(1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6-triamine, blongs to pyrimidines compound. name: 2-(1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6-triamine

B, to 500 ml reaction vial the adding step a 29.0g (0.083mol) compound 3,150 ml methanol, 9.7g (0.1mol) carbonic acid dimethyl ester (compound 4), in 30 C stirring reaction under 6h; after the reaction, the obtained reaction solution in the 50 C, vacuum 0.09 MPa reducing pressure and evaporating the solvent, the residue obtained by adding 150 ml ethyl acetate stirring 15 min, filter, the filtration cake at the 65 C, vacuum 0.09 MPa dry the 5h, to obtain 4,6-diamino-2 – [1 – (2-fluorobenzyl) – 1H-pyrazolo [3,4-b] pyridin-3-yl] – 5-pyrimidinyl amino a acid methyl ester (compound 5) 29.8g (yield 88%);

The synthetic route of 428854-24-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Drug Technology Co., Ltd.; Mao, Ying; Bi, Tianhao; Li, Jinhua; Liu, Zhiqing; Lou, Lili; Zhang, Jiamei; (11 pag.)CN105294686; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 428854-24-4, name is 2-(1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6-triamine, molecular formula is C17H15FN8, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 2-(1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6-triamine

Acetone (SO ml) was added to 2-(l-(2-fluorobenzyl)-1H-pyrazo]o[3,4-b]pyridin-3-yl) pyrimidine-4,S,6-triamine (10 gms) compound of formula-2 at 25-30C and stirred for 10 minutes at the same temperature. Dimethyl sulfate (10.79 gms) was slowly added to the reaction mixture at 25-30C and stirred for 40 hours at the same temperature. Filtered the precipitated solid, washed with acetone and dried to get the title compound. Yield: 8 gms.

With the rapid development of chemical substances, we look forward to future research findings about 428854-24-4.

Reference:
Patent; MSN LABORATORIES PRIVATE LIMITED, R&D CENTER; THIRUMALAI RAJAN, Srinivasan; ESWARAIAH, Sajja; VENKATA PANAKALA RAO, Gogulapati; RAJESHWAR REDDY, Sagyam; BALA NARSAIAH, Eppaturi; SRINIVASULU, Rangineni; (32 pag.)WO2018/96550; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 428854-24-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 428854-24-4, name is 2-(1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6-triamine. This compound has unique chemical properties. The synthetic route is as follows.

Example 51 4-Amino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5,8-dihydropteridine-6,7-dione 300 mg (0.856 mmol) of the compound from example 1A were dissolved in 3 ml of ethanol, and 116 mul (0.856 mmol) of diethyl oxalate and 79 mg (1.156 mmol) of sodium methoxide were added. The mixture was heated to reflux for 10 h. The reaction mixture was stirred with 10 ml of ethanol. The precipitate was filtered off and stirred with 10 ml of water and then with 10 ml of acetonitrile. The precipitate was filtered off and dried under high vacuum. 112 mg of the title compound were obtained (30% of theory). LC-MS (method 2): Rt=0.80 min; MS (EIpos): m/z=405 (M+H)+. 1H NMR (400 MHz, DMSO-d6): delta [ppm]=5.82 (s, 2H), 7.12-7.25 (m, 4H), 7.33-7.40 (m, 2H), 8.64 (dd, 1H), 9.14 (dd, 1H), 12.44 (s, 1H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 428854-24-4, 2-(1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6-triamine.

Reference:
Patent; BAYER INTELLECTUAL PROPERTY GMBH; Follmann, Markus; Stasch, Johannes-Peter; Redlich, Gorden; Ackerstaff, Jens; Griebenow, Nils; Knorr, Andreas; Wunder, Frank; Li, Volkhart Min-Jian; Baerfacker, Lars; Weigand, Stefan; US2014/148433; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 428854-24-4, 2-(1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6-triamine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2-(1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6-triamine, blongs to pyrimidines compound. Safety of 2-(1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6-triamine

Example 9A 3-Bromo-1,1,1-trifluoropropan-2-yl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate 0.888 ml (8.563 mmol) of 3-bromo-1,1,1-trifluoro-2-propanol were initially charged in 22 ml of dichloromethane, 952 mg (3.211 mmol) of bis(trichloromethyl) carbonate were added and the mixture was cooled to 0 C. Thereafter, 0.519 ml (6.422 mmol) of pyridine were added dropwise and the mixture was stirred at 0 C. for 1 h. Then 1.5 g (4.281 mmol) of the compound from example 1A dissolved in pyridine (11 ml) were added and the mixture was stirred at 0 C. for a further 30 min. After a further 12 h at RT, the reaction was stopped by addition of 30 ml of saturated aqueous sodium hydrogencarbonate solution and extracted three times with dichloromethane. The combined organic phases were dried with sodium sulfate and concentrated under reduced pressure. The residue was purified by chromatography on silica gel (dichloromethane/methanol gradient). This gave 532 mg (21% of theory) of the title compound. LC-MS (method 2): Rt=0.92 min; MS (EIpos): m/z=569/571 [M+H, Br pattern]+.

The synthetic route of 428854-24-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER INTELLECTUAL PROPERTY GMBH; Follmann, Markus; Stasch, Johannes-Peter; Redlich, Gorden; Ackerstaff, Jens; Griebenow, Nils; Knorr, Andreas; Wunder, Frank; Li, Volkhart Min-Jian; Baerfacker, Lars; Weigand, Stefan; US2014/148433; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 428854-24-4, name is 2-(1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6-triamine, the common compound, a new synthetic route is introduced below. Quality Control of 2-(1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6-triamine

n three flask, pyridine (5mL), was added compound 7 (350mg, 1mmol, 1.0eq), stirred for 20 minutes in an ice bath, was added methyl chloroformate (162mg, 1.5mmol, 1.5eq), continued in an ice bath the mixture was stirred for 1 hour. Warmed to room temperature and stirring was continued for 2 hours. After completion of the reaction, concentrated under reduced pressure, the residue was dissolved in ethanol, and then concentrated under reduced pressure was repeated twice to give a yellow solid (390 mg of), a yield of 95.7%.

The synthetic route of 428854-24-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Okuura Dayton (Shanghai) Pharmaceutical Co., Ltd; Shanghai Pharmaceutical Group Co., Ltd; Yu, Libing; Guo, Maojun; Yang, Qingang; Ji, Zhangyou; (16 pag.)CN105777743; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 428854-24-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.428854-24-4, name is 2-(1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6-triamine, molecular formula is C17H15FN8, molecular weight is 350.35, as common compound, the synthetic route is as follows.

Step three, A solution of formic acid (129 g, 1.37 mol)Was added dropwise to acetic anhydride (145 g, 1.42 mol)After stirring for half an hour, compound 4 (80 g, 0.23mo 1) was added at 0 C, stirred at 20 C for 10 hours,TLC detection reaction is completed, concentrated reaction solution, add 500mL of water for half an hour, pumping,Dried to give about 78 g of a yellow solid which was dissolved in 500 mL of tetrahydrofiramidate and sodium borohydride (15.58 g, 0.41 mol) was added at room temperature. A solution of boron trifluoride diethyl ether (90 mL) was slowly added dropwise at room temperature, Slowly heated to reflux for 3 hours. After the reaction, add 120mL methanol to destroy, then add 2N hydrochloric acid 120mL, stir for half an hour after the reaction system, the residue with 2N sodium hydroxide solution to adjust the pH to neutral, and then suction, Drying to obtain a crude product of compound 5a,The crude product of compound 5a was dissolved in a mixed solvent of dichloromethane and methanol (the weight ratio of the crude product of compound 5a to 1: 5, the volume ratio of dichloromethane to methanol in the mixed solvent was 1: 15) ,And the mixture was stirred at room temperature for 10 hours and then filtered and dried to obtain pure product (63.7 g, 0.17 mol, yield: 76%, content: 99%) /

The chemical industry reduces the impact on the environment during synthesis 428854-24-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Anhui Lianchuang Biological Medicine Co.,Ltd; GE, DEPEI; WU, QIHUA; LIU, TAO; (10 pag.)CN104530044; (2016); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 428854-24-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 428854-24-4 as follows.

Example 48 4-Amino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pteridin-7(8H)-one 300 mg (0.856 mmol) of the compound from example 1A were dissolved in 20 ml of ethanol, and 187 mul (0.942 mmol) of a 50% solution of ethyl glyoxalate in toluene were added. The mixture was heated to reflux for 1 h, 2 drops of concentrated sulfuric acid were added and the mixture was heated to reflux for a further 16 h. The precipitate was filtered off and dried under high vacuum. 83 mg of the title compound were obtained (23% of theory). LC-MS (method 3): Rt=0.93 min; MS (EIpos): m/z=389 (M+H)+. 1H NMR (400 MHz, DMSO-d6): delta [ppm]=5.85 (s, 2H), 7.13-7.26 (m, 3H), 7.34-7.39 (m, 1H), 7.43 (dd, 1H), 7.74-8.01 (m, 3H), 8.66 (dd, 1H), 9.17 (dd, 1H), 12.86 (s, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,428854-24-4, its application will become more common.

Reference:
Patent; BAYER INTELLECTUAL PROPERTY GMBH; Follmann, Markus; Stasch, Johannes-Peter; Redlich, Gorden; Ackerstaff, Jens; Griebenow, Nils; Knorr, Andreas; Wunder, Frank; Li, Volkhart Min-Jian; Baerfacker, Lars; Weigand, Stefan; US2014/148433; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia