Category: 434941-55-6

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 434941-55-6, name is 4-(4-Chlorophenyl)-2-(methylthio)pyrimidine. A new synthetic method of this compound is introduced below., Formula: C11H9ClN2S

4-(4-chlorophenyl)-2-(methylsulfonyl)pyrimidine To a solution of 4-(4-chlorophenyl)-2-methylthiopyrimidine (1.1 g, 4.65 mmol) in acetone (30 ml) and water (10 ml) was added oxone (7.14 g, 11.62 mmol). The reaction mixture was stirred for 18 hours then diluted with water and extracted into dichloromethane. The extracts were dried over magnesium sulfate, filtered and concentrated to provide a white solid: EI-MS (m/z) 269 [M+1]+.

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Reference:
Patent; Satoh, Yoshitaka; Bhagwat, Shripad S.; US2004/106634; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 434941-55-6, 4-(4-Chlorophenyl)-2-(methylthio)pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyrimidines, blongs to pyrimidines compound. category: pyrimidines

Step 2: At 0C, mCPBA (70% w/w; 483 mg, 2.02 mmol, 2.2 eq) is added portionwise to intermediate 19 (217 mg, 0.92 mmol, 1.0 eq) in DCM (5 mL). The reaction is stirred at r.t. for 2 h and the solid is filtered and washed with DCM. The organics is washed with saturated aqueous solution of NaHC03 and dried over anhydrous Na2S04. The solvent evaporated under reduced pressure to afford intermediate 20. LC-MS conditions: LC-MS 5

The synthetic route of 434941-55-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; AISSAOUI, Hamed; BOSS, Christoph; CIANA, Claire-Lise; SIEGRIST, Romain; WO2014/72903; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia