Category: 4472-45-1

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4472-45-1, name is 4-Chloro-2,6-dimethylpyrimidine, molecular formula is C6H7ClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 4472-45-1

A solution of tert-butyl (6R)-6-methyl-1,2,5-oxadiazepane-5-carboxylate (4.40 g) obtained in Step E of Example 194 and 4-chloro-2,6-dimethylpyrimidine (3.19 g) in 2-propanol (45 mL) was stirred at 70 C. for 16 hr. The mixture was concentrated under reduced pressure, to the residue was added saturated aqueous sodium hydrogencarbonate solution, and the mixture was extracted with ethyl acetate. The obtained organic layer was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (NH, hexane/ethyl acetate) to give the title compound (6.28 g). 1H NMR (300 MHz, CDCl3) delta 1.15-1.29 (3H, m), 1.47 (9H, s), 2.39 (3H, s), 2.51 (3H, s), 3.34-3.55 (1H, m), 3.70-4.60 (6H, m), 6.61 (1H, s). MS: [M+H]+ 323.1.

With the rapid development of chemical substances, we look forward to future research findings about 4472-45-1.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; KAMEI, Taku; ARIKAWA, Yasuyoshi; OHASHI, Tomohiro; IMAEDA, Toshihiro; FUJIMORI, Ikuo; MIKI, Takashi; YONEMORI, Jinichi; OGURO, Yuya; SUGIMOTO, Takahiro; SETO, Masaki; NISHIDA, Goushi; KAMATA, Makoto; IMOTO, Hiroshi; (132 pag.)US2018/155333; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4472-45-1, name is 4-Chloro-2,6-dimethylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 4-Chloro-2,6-dimethylpyrimidine

General procedure: N-(2-Chloropyrimidin-5-yl)acetamide (CAS 1353776-97-2; 0.89 mg, 0.36 mmol) was added to a stirred solution of Intermediate 14 (130 mg, 0.42 mmol) and diisopropylethylamine (0.13 mL, 0.91 mmol) in isopropanol (1.7 mL) at rt. The mixture was stirred at 100 C for 16 h and then the volatiles were evaporated in vacuo. The residue thus obtained was purified by flash column chromatography (silica gel, MeOH in DCM, 0/100 to 10/90). The desired fractions were concentrated in vacuo to yield a crude product that was further purified by RP HPLC (stationary phase: CI 8 XBridge 30 x 100 mm 5 muetaiota; mobile phase: gradient from 90% lOmM NH4CO3H pH 9 solution in water, 10% CH3CN to 0% lOmM NH4CO3H pH 9 solution in water, 100% CH3CN). The desired fractions were concentrated in vacuo to yield product 16 (40 mg, 27% yield) as a solid.

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Reference:
Patent; JANSSEN PHARMACEUTICA NV; BARTOLOME-NEBREDA, Jose Manuel; TRABANCO-SUAREZ, Andres Avelino; MARTINEZ VITURRO, Carlos Manuel; (116 pag.)WO2018/141984; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4472-45-1, name is 4-Chloro-2,6-dimethylpyrimidine. A new synthetic method of this compound is introduced below., Application In Synthesis of 4-Chloro-2,6-dimethylpyrimidine

2,4-Dimethylpyrimidine-6-d (12-6-d). To a suspension of 6-chloro-2,4-dimethylpyrimidine (0.40 g, 2.8 mmol),sodium carbonate (1.50 g), 10% Pd-C (0.30 g) in methanol-d (20 mL) was passed D2 (g) for 4 hours. Kugelrohr distillation (100 oC, 1 mmHg) gave the title compound 12-6-d as a colorless liquid (0.27 g, 87%); 1H NMR (CDCl3) 2.50 (s, 3H), 2.60 (s, 3H) 7.40 (s, 1H), 8.40 (residual proton at C-6 (d, J 5.1 Hz); 13C NMR (CDCl3) 24.1 (CH3),24.7 (CH3), 118.0 (C-5), 156.9 (C-6, t, J 26.8 Hz), 167.3 (C-4), 168.2 (C-2).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4472-45-1, 4-Chloro-2,6-dimethylpyrimidine.

Reference:
Article; Pavlik, James W.; Vongakorn, Tharinee; Kebede, Naod; Arkivoc; vol. 2017; 5; (2017); p. 216 – 228;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4472-45-1, name is 4-Chloro-2,6-dimethylpyrimidine, the common compound, a new synthetic route is introduced below. SDS of cas: 4472-45-1

General procedure: To a solution of 2,4-Dichloropyrimidine (1) (0.149g, 1.0 mmol) in 15 mL isopropanol was added 4-methoxy-N-methylaniline derivative (2) (1.0 mmol). The reaction mixture was stirred at room temperature and monitored by TLC. When the reaction was completed, the solvent was removed under vacuum and the slurry was dilute with water (10 mL). The solution was adjusted to pH 9 with a saturated NaHCO3 solution, extracted with ethyl acetate (10 mL¡Á3) for three times, the organic phase was washed with water (10 mL), dried over sodium sulfate, concentrated and purified by column chromatography to give the target compound 3a-3b.

The synthetic route of 4472-45-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Xu, Shaoyu; An, Baijiao; Li, Yuxin; Luo, Xunbang; Li, Xingshu; Jia, Xian; Bioorganic and Medicinal Chemistry Letters; vol. 28; 10; (2018); p. 1769 – 1775;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia