Category: 4489-34-3

Related Products of 4489-34-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4489-34-3, name is 4,6-Dichloro-2-methylsulfonylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

A suspension of compound A (1Og, 44.04 mmol) and cyclopropane carboxylic acid (4-mercapto~phenyl)-amide (B, 8.51 g, 44.04 mmol) in t-butanol (300 ml) was degassed by evacuation, then flushing with nitrogen. The mixture was stirred at 90 C under nitrogen atmosphere for 1 hour then the solvent was removed in vacuo. The residue was dissolved in ethyl acetate (600 ml) and washed with an aqueous solution of potassium carbonate and sodium chloride. The organic extract was dried over magnesium sulphate, concentrated to a low volume and allowed to crystallize. The product C was collected as colourless crystals, (11.15 g, 74%). 1H-NMR DMSO-d6, delta 0.82-0.89 (4H, m), 1.80-1.88 (IH, m), 7.55 (2H, d), 7.70-7.76 (3H, m), 10.49 (IH, s); M+H, 340.

According to the analysis of related databases, 4489-34-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK & CO., INC.; BANYU PHARMACEUTICAL CO., LTD.; VERTEX PHARMACEUTICALS INCORPORATED; BUSER-DOEPNER, Carolyn, A.; WO2007/136615; (2007); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 4489-34-3, 4,6-Dichloro-2-methylsulfonylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 4,6-Dichloro-2-methylsulfonylpyrimidine, blongs to pyrimidines compound. Recommanded Product: 4,6-Dichloro-2-methylsulfonylpyrimidine

General procedure: The general synthetic route for the preparation of tozasertib (a-d) and tozasertib analogs (B: a, e-g; A: a, h-j) is shown in Fig. 1. Reagents and conditions: (a) 3-chloroperoxybenzoic acid, DCM, rt, 3h; (b) N-(4- mercaptophenyl)cyclopropanecarboxamide, TEA, CH3CN, 80 C, 3-1 Oh; (c) 5-methyl- 1 H-pyrazol-3-amine, DIPEA, DMF, 95 C, 16h; (d) amine (1-methylpiperazine or morpholine), DMF, DIPEA, 90 C, 6-12h; (e) corresponding thiol, TEA, CH3CN, 80 C, 3-1 Oh; (f) 5-methyl-1 H-pyrazol-3-amine, DIPEA, dioxane, 95 C, 3-6 h, (g) amine (1-methylpiperazine or morpholine), DMF, DIPEA, 90 C, 6-12h; (h) thiophenol, TEA, THF, 50 C; (i) corresponding amine, DIPEA, dioxane, 95 C, 3-6 h; (j) amine (1- methylpiperazine or morpholine), DMF, DIPEA, 90 C, 6-12h. (0097) The structures and batch purities (>90%) of the compounds have been confirmed by using standard analytical methods (LC/MS and NMR).

The synthetic route of 4489-34-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BIOMED X GMBH; SAMEH, Eid; FULLE, Simone; MERGET, Benjamin; TURK, Samo; (43 pag.)WO2019/101843; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia