Category: 45588-79-2

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.45588-79-2, name is 4-(Aminomethyl)pyrimidine, molecular formula is C5H7N3, molecular weight is 109.1292, as common compound, the synthetic route is as follows.category: pyrimidines

General procedure: Intermediate 1-2-1 Preparation of 4,4-dimethyl-6-oxo-N-phenyl-2-[(pyrimidin-4-ylmethyl)amino]cyclohex-1-ene-1-carbothioamideSynthesized according to Method B1. Intermediate 1 -1 -1 (906 mg) gave the desired product (500 mg, 34%) and 6,6-dimethyl-3-(phenylamino)-2-(pyrimidin-4-yl)-1 ,5,6,7- tetrahydro-4H-indol-4-one (34 mg, 6% Example 5) after preparative HPLC (XBrigde C18 5muetaiota 100×30 mm, Solvent: A = H20 + 0.2% Vol. NH3 (32%), B = Acetonitrile, 33% B in A to 56% in A over 5.5 min, flow: 70ml_/min). 1 H NMR (300 MHz, DMSO-d6) delta [ppm]= 0.90 – 1 .07 (m, 6 H) 2.39 (s, 2 H) 2.62 – 2.79 (m, 2 H) 4.96 (d, 2 H) 7.17 – 7.28 (m, 1 H) 7.39 (t, 2 H) 7.47 (d, 2 H) 7.55 (d, 1 H) 8.83 (d, 1 H) 9.18 (s, 1 H) 14.00 (br. s., 1 H) 14.58 (br. s., 1 H)Method B1 Preparation of 2-(amino)-6-oxocyclohex-1 -ene-1 -carbothioamides (Formula 1- 2)mixture of the 2-hydroxy-6-oxocyclohex-1 -ene-1 -carbothioamides (Formula 1 -1 ) and the 4-aminomethylheterocycle (Reagent B) was heated under an Argon atmospshere in either EtOH, EtOAc or DMSO optionally using 4A molecular sieves to remove water from the reaction mixture. The reaction was concentrated and purified either column chromatography or preparative HPLC.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,45588-79-2, 4-(Aminomethyl)pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; GRAHAM, Keith; KLAR, Ulrich; BRIEM, Hans; HITCHCOCK, Marion; BAeRFACKER, Lars; EIS, Knut; SCHULZE, Volker; SIEMEISTER, Gerhard; BONE, Wilhelm; SCHROeDER, Jens; HOLTON, Simon; LIENAU, Philip; TEMPEL, Rene; SONNENSCHEIN, Helmut; BALINT, Jozsef; GRAUBAUM, Heinz; (577 pag.)WO2015/193339; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

45588-79-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 45588-79-2, name is 4-(Aminomethyl)pyrimidine. A new synthetic method of this compound is introduced below.

To a stirred solution of 4-(cis-8-(dimethylamino)-3-oxo-8-phenyl-2-azaspiro[4. 5]decan-2- yI)-2,2-dimethylbutanoic acid hydrochloride (300mg, 0.71 mmol) in THF(1 0mL), diisopropylethylamine (490mg, 3.8Ommol) and HATU (541mg, 1 .43mmol) were added at RT. The reaction mixture was stirred at RT for 45mm and then pyrimidin-4-yl- methanamine (114mg, 1 .O45mmol) was added at 0C. The reaction mixture was warmedto RT and stirred for 16h. The reaction mixture was quenched with saturated NaHCO3 Solution, extracted with 10%methanol in DCM (3X25mL). The combined organic extracts were dried over anhydrous Na2SO4 and concentrated under reduced pressure to give the crude compound. Purification by column chromatography over silica gel (100-200 mesh) by using 1 0%methanol in DCM with traces of ammonia as eluent to give 160mg ofcompound which was further purified by preparative TLC by using 5% methanol in DCM as mobile phase to give 110 mg (33%) of cis- 4-(8-Dimethylamino-3-oxo-8-phenyl-2- azaspiro[4.5]decan-2-yl)-2,2-dimethyl-N-(pyrimidin-4-yl-methyl)-butyramide as solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 45588-79-2, 4-(Aminomethyl)pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GRUeNENTHAL GMBH; WEGERT, Anita; KUeHNERT, Sven; KOENIGS, Rene, Michael; NOLTE, Bert; LINZ, Klaus; HARLFINGER, Stephanie; KOeGEL, Babette-Yvonne; RATCLIFFE, Paul; THEIL, Fritz; GROeGER, Olga; BRAUN, Birgit; (223 pag.)WO2016/8582; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia