Category: 461-98-3

Synthetic Route of 461-98-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 461-98-3, name is 2,6-Dimethylpyrimidin-4-amine. This compound has unique chemical properties. The synthetic route is as follows.

Step 5 : 3,5-Dichloro-4-[4-(2,6-dimethylpyrimidin-4-ylamino)^ A suspension of 3,5-dichloro-4-(4-chloropyrazolo[4,3-c]pyridin-2-yl)benzonitrile (65 mg, 0.20 mmol), 4- amino-2,6-dimethylpyrimidine (27 mg, 0.22 mmol), Pdi(dba)3 (5 mg, 0.005 mmol), Xantphos (12 mg, 0.02 mmol) and cesium carbonate (91 mg, 0.28 mmol) in dioxane (2 mL) was sealed in a reaction vial, purged with nitrogen, and heated at 90 C for 18 hours. The reaction mixture was cooled, filtered, and concentrated under reduced pressure. The residue was purified by silica gel flash chromatography (30-100% ethyl acetate in cyclohexane), then by HPLC (gradient: 25 to 98% acetonitrile in water with 0.1% ammonium hydroxide), to afford the title compound as a white solid (22 mg, 27% yield). ? NMR (400 MHz, DMSO-d6): d 9.41 (d, J = 0.9 Hz, 1H), 8.51 (s, 2H), 8.08 (d, J = 6.9 Hz, 1H), 7.67 (s, 1H), 7.54 (dd, J = 6.9, 1.0 Hz, 1H), 2.73 (s, 3H), 2.58 (s, 3H). LCMS (Method B): RT = 3.00 min, m/z: 410.15 [M+H+].

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 461-98-3, 2,6-Dimethylpyrimidin-4-amine.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; BLENCH, Toby; GOODACRE, Simon; LAI, Yingjie; LIANG, Yun; MACLEOD, Calum; MAGNUSON, Steven; TSUI, Vickie; WILLIAMS, Karen; ZHANG, Birong; WO2012/66061; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 461-98-3, Adding some certain compound to certain chemical reactions, such as: 461-98-3, name is 2,6-Dimethylpyrimidin-4-amine,molecular formula is C6H9N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 461-98-3.

Preparation of the starting compound STR11 6.9 g (0.08 mol) of cyanoacetic acid and 10 g (0.08 mol) of 4-amino-2,6-dimethylpyrimidine are dissolved in 80 ml of pyridine, and 8.3 g (0.08 mol) of acetic anhydride are added. The pyridine is subsequently removed in vacuo, and the residue is taken up in toluene, concentrated, taken up a second time in toluene and again concentrated. The residue is chromatographed using ethyl acetate as eluent. 7.8 g (50.5% of theory) of 2,6-dimethyl-4-cyano-acetamido-pyrimidine of melting point 178 C. are obtained.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 461-98-3, 2,6-Dimethylpyrimidin-4-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Bayer Aktiengesellschaft; US4886833; (1989); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 461-98-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.461-98-3, name is 2,6-Dimethylpyrimidin-4-amine, molecular formula is C6H9N3, molecular weight is 123.16, as common compound, the synthetic route is as follows.

The mixture of 4-bromo-7-fluoro-2-(2,6-dichlorophenyl)-lH-imidazo[4,5-c]pyridine (50 mg, 0.14 mmol), 2,6-dimethylpyrimidine-2 -amine (22 mg, 0.18 mmol), Pd2(dba)3 (4 mg, 0.0040 mmol), XantPhos (2 mg, 0.002 mmol), Cs2C03 (90 mg, 0.28 mmol) in 1,4-Dioxane (10 mL) and DME (2 mL) was degassed with N2 for 1 min. The resulting mixture was irradiated in a microwave reactor at 170 C for 2 hrs and cooled to room temperature. The mixture was filtered with Celite and the filtrate was concentrated and purified by prep-HPLC (Gilson GX 281, Shim-pack PRC-ODS 250 mm x 20 mm x 2, gradient: CH3CN / 10 mm/L NH4HCO3, 17 min) to give the desired product (27 mg, yield: 48%). ¾ NMR (DMSO- 6, 500 MHz): delta 8.30 (d, J = 6.0 Hz, 1H), 7.95 (s, 1H), 7.61 (m, 4H), 2.39 (s, 3H), 2.34 (s, 3H). LC-MS(ESI) m/z: 404.4 [M+H+].

Statistics shows that 461-98-3 is playing an increasingly important role. we look forward to future research findings about 2,6-Dimethylpyrimidin-4-amine.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; LAI, Yingjie; LIANG, Jun; MAGNUSON, Steven R.; TSUI, Vickie H.; ZHANG, Birong; ROBARGE, Kirk; WO2011/113802; (2011); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 461-98-3 ,Some common heterocyclic compound, 461-98-3, molecular formula is C6H9N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a microwave tube was added 4-bromo-2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridine (60 mg, 0.17 mmol), 2,6-dimethylpyrimidin-4-amine (0.027 g, 0.22 mmol), Pd2(dba)3 (0.013 g, 0.017 mmol), XantPhos ((0.017 g, 0.034 mmol) and Cs2C03 (0.111 g, 0.34 mmol) in dioxane (3.0 mL). The mixture was degassed with N2 for 10 minutes and then irradiated in a microwave reactor at 160 C for 2 hours. After cooling to room temperature the solid was removed via filtration. The filtrate was concentrated under reduced pressure and the residue was purified with reverse phase column chromatography eluting with a 0-60% gradient of CH3CN in 0.5% NH4HC03 to give the desired product as a white solid (14 mg, 21% yield). ? NMR (500 MHz, CH3OH-??: delta 8.44 (d, J = 5.5 Hz, 1H), 7.71 (d, J = 5.5 Hz, 1H), 7.56-7.51 (m, 4H), 7.31 (s, 1H), 2.44 (s, 3H), 2.35 (s, 3H). LCMS (Method A): RT = 5.75 min, m/z: 402.0 [M+H+].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,461-98-3, its application will become more common.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; BLENCH, Toby; ELLWOOD, Charles; GOODACRE, Simon; LAI, Yingjie; LIANG, Jun; MACLEOD, Calum; MAGNUSON, Steven; TSUI, Vickie; WILLIAMS, Karen; ZHANG, Birong; WO2012/35039; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 461-98-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 461-98-3, name is 2,6-Dimethylpyrimidin-4-amine. A new synthetic method of this compound is introduced below.

2-(2,6-Dimethyl-pyrimidin-4-ylamino)-thiazole-5-carbonitrile (22-3) 4-amino-2,6-dimethylpyrimidine (93 mg, 0.76 mmol)was dissolved in 1.4 mL anhydrous DMF and sodium hydride (66mg, 60% dispersion, 2.77 mmol) was added at room temperature. When the bubbling stopped, 2-chloro-thiazole-5-carbonitrile (0.100 g, 0.692 mmol) was added and the reaction was stirred at room temperature. After 4 hours, 1M HCl was added until the solution was neutral. The resulting precipitate was filtered, washed with water, and dried under high vacuum. The material was washed with hexane and filtered again and air dried to afford the title compound. 1H-NMR (300 MHz, DMSO-d6) 12.47 (1H,s), 8.32 (1H,s), 6.75 (1H,s), 2.58 (3H,s), 2.38 (3H,s). M+1=232.1. MP>250

At the same time, in my other blogs, there are other synthetic methods of this type of compound,461-98-3, 2,6-Dimethylpyrimidin-4-amine, and friends who are interested can also refer to it.

Reference:
Patent; Bilodeau, Mark T.; Hartman, George D.; Hoffman JR., Jacob M.; Sisko, John T.; Manley, Peter J.; Smith, Anthony M.; Tucker, Thomas J.; Lumma JR., William C.; Rodman, Leonard; US2002/137755; (2002); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 461-98-3, 2,6-Dimethylpyrimidin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 461-98-3, blongs to pyrimidines compound. 461-98-3

To a 200 ml flask was added 4-amino-2-chloro-5-nitropyridine (1.00 g, 5.76 mmol), 4-amino-2,6-dimethylpyrimidine (1.42 g, 11.5 mmol), Pd2(dba)3 (0.528 g, 0.576 mmol), XantPhos (0.400 g, 0.691 mmol), Cs2CO3 (4.13 g, 12.7 mmol) and dioxane (45 mL). The mixture was degassed with N2 for 2 min and then heated at 110 C. for 16 hrs. After cooling to room temperature the reaction was filtered and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (0-10% methanol/dichloromethane) to give N-(2,6-dimethylpyrimidin-4-yl)-5-nitropyridine-2,4-diamine (0.348 g, yield: 23%). LCMS (ESI) m/z: 261.2 [M+H+].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,461-98-3, its application will become more common.

Reference:
Patent; GENENTECH, INC.; US2010/317643; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia