Category: 46155-89-9

Reference of 46155-89-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 46155-89-9, name is 1,3-Dimethyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 111 5-[4-(4-Chlorobenzoyl)benzyl]-1,3-dimethylpyrrolo [3,2-d]pyrimidine-2,4-dione To a solution of 1,3-dimethylpyrrolo[3,2-d]-pyrimidine-2,4-dione (0.402 g, 2.24 mmol) and 4-(4-chlorobenzoyl) benzyl bromide (1.20 g, 3.88 mmol) in DMF (5 ml) was added potassium carbonate (0.73 g, 5.28 mmol) and the mixture was stirred at 60 C. for 2 hours. The solvent was then distilled off under reduced pressure and the residue was diluted with water and extracted with ethyl acetate. The organic layer was washed with saturated aqueous NaCl solution, dried over MgSO4, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (developer: isopropyl ether: ethyl acetate: methylene chloride=2:1:1) and recrystallized from ethyl acetate to provide colorless needles. 0.360 g (39%) 1 H-NMR (CDCl3) delta: 3.40(3H,s), 3.49(3H,s), 5.66(2H,s), 6.00(1H,d,J=3.0 Hz), 7.01(1H,d,J=3.0 Hz), 7.29(2H,d,J=8.6 Hz), 7.45(2H,d,J=8.6 Hz), 7.72(2H,d,J=8.6 Hz),,7.73(2H,d,J=8.6 Hz). IR (KBr): 1693, 1653, 1549, 1466, 1434, 1406, 1267, 1065, 1016, 962, 922, 856, 744, 669, 503 cm-1.

According to the analysis of related databases, 46155-89-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Takeda Chemical Industries, Ltd.; US5753664; (1998); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 46155-89-9, 1,3-Dimethyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 46155-89-9, blongs to pyrimidines compound. Recommanded Product: 46155-89-9

A solution of 1 g (5.58 mmol)of compound 1a in 5 mL of concentrated sulfuric acid was cooled to 2-5C, and a mixture of 0.37 mL(5.58 mmol) of nitric acid (d = 1.41 g/cm3) and 2 mL of concentrated sulfuric acid was added dropwise with vigorous stirring and cooling. The mixture was stirred for 1 h and poured onto 20 g of ice. After 30 min, the precipitate was filtered off and washed with 10 mL of water. Yield 0.77 g (62%, assuming formation of mononitro derivatives). According to the 1H NMR data, the product was a mixture of 6- and 7-nitro derivatives ata ratio of 7 : 93. It was recrystallized from 55 mL of ethanol to isolate 0.47 g (38%) of 7-nitro isomer 2a,mp 272-273C. IR spectrum, nu, cm-1: 3150 m (NH),1710 s, 1680 s (C=O), 1575 s, 1390 s (NO2). 1H NMRspectrum (DMSO-d6), delta, ppm: 3.25 s (3H, 1-CH3),3.58 s (3H, 3-CH3), 8.27 d (1H, 6-H, J = 3.47 Hz),13.55 br.s (1H, NH). Found, %: C 42.73; H 3.70;N 24.88. C8H8N4O4. Calculated, %: C 42.86; H 3.60;N 24.99.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,46155-89-9, 1,3-Dimethyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione, and friends who are interested can also refer to it.

Reference:
Article; Tkachenko, Yu. N.; Popov; Pozharskii; Borodkin; Levchenkov; Russian Journal of Organic Chemistry; vol. 53; 10; (2017); p. 1564 – 1572; Zh. Org. Khim.; vol. 53; 10; (2017); p. 1536 – 1543,8;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 46155-89-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 46155-89-9, name is 1,3-Dimethyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione. This compound has unique chemical properties. The synthetic route is as follows.

Intermediate 3 1 ,3,7-Trimethyl- lH-pyrrolo[3,2-^]pyrimidine-2,4(3H,5H)-dioneCH3CH3Step 1 l,3-Dimethyl-2,4-dioxo-2,3,4,5-tetrahydro-l//-pyrrolo[3,2-c/]pyrimidine-7- carbaldehyde: At a temperature of 5-10C, phosphorous oxychloride (1.84 ml, 20.087 mmol) was mixed with iV.iV-dimethylformamide (2 mL). Then a solution of Intermediate 1 (600 mg, 3.348 mmol) in vV.jV-dimethylformamide (3 mL) was added while stirring. The reaction mixture was held for 2 h at 950C, cooled and poured onto ice (10 g). The precipitate formed was filtered off and recrystallised from water to give 300 mg of the product as an off-white solid; 1H NMR (delta ppm, 300 MHz, DMSO-^6) 3.25 (s, 3H), 3.75 (s, 3H), 8.06 (s, IH), 9.79 (s, IH), 13.15 (br s, IH); APCI-MS (m/z) 208.20 (M+H)+.

According to the analysis of related databases, 46155-89-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLENMARK PHARMACEUTICALS S.A.; CHAUDHARI, Sachin, Sundarlal; KUMAR, Sukeerthi; THOMAS, Abraham; PATIL, Nisha, Parag; KADAM, Ashok, Bhausaheb; DESHMUKH, Vishal, Govindrao; DHONE, Sachin Vasantrao; CHIKHALE, Rajendra, Prakash; KHAIRATKAR-JOSHI, Neelima; MUKHOPADHYAY, Indranil; WO2010/109287; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 46155-89-9, name is 1,3-Dimethyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione. This compound has unique chemical properties. The synthetic route is as follows. name: 1,3-Dimethyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione

1,3-Dimethyl-1,5-dihydro-pyrrolo[3,2-d]pyrimidine-2,4-dione 9 (2 g, 11.2 mmol) was dissolved in DMF (15 mL), K2CO3 (3.1 g, 22.4 mmol) was added and the mixture was stirred at room temperature for 10 min. After cooling at 0 C, a solution of ethyl bromoacetate (2.05 g, 12.32 mmol) in DMF (5 mL) was added dropwise and the reaction was stirred at room temperature for a further 3 h. The solvent was evaporated and the residue partitioned between EtOAc (15 mL) and water (20 mL). The aqueous phase was further extracted with EtOAc (2 × 15 mL) and the organic layers were dried over anhydrous Na2SO4. Evaporation of the solvent gave a solid residue which was filtered after suspension with a 1:1 mixture of Et2O/Petroleum ether (15 mL). White solid; 80% yield; mp 171-172 C; 1H NMR (200 MHz, CDCl3): delta (ppm) 1.29 (t, 3H, J = 7.4), 3.37 (s, 3H), 3.46 (s, 3H), 4.23 (q, 2H, J = 7), 5.10 (s, 2H), 5.99 (d, 1H, J = 3), 6.93 (d, 1H, J = 3). MS (ESI): [MH]+ = 265.3.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 46155-89-9, 1,3-Dimethyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione.

Reference:
Article; Baraldi, Pier Giovanni; Romagnoli, Romeo; Saponaro, Giulia; Aghazadeh Tabrizi, Mojgan; Baraldi, Stefania; Pedretti, Pamela; Fusi, Camilla; Nassini, Romina; Materazzi, Serena; Geppetti, Pierangelo; Preti, Delia; Bioorganic and Medicinal Chemistry; vol. 20; 5; (2012); p. 1690 – 1698;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia