Category: 479691-42-4

Application of 479691-42-4 ,Some common heterocyclic compound, 479691-42-4, molecular formula is C13H19ClN4O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Preparation of compound 38: A solution of compound 37 in 20 ml of ether/HCl was allowed to stir at room temperature under nitrogen atmosphere for 1 h. The excess solvent was distilled off under reduced pressure and the crude material was washed with n-pentane and dried to yield 180 mg of compound 38 in quantitative yield.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,479691-42-4, its application will become more common.

Reference:
Patent; Salituro, Francesco G.; Saunders, Jeffrey O.; Yan, Shunqi; US2010/331307; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 479691-42-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 479691-42-4, name is tert-Butyl 4-(4-chloropyrimidin-2-yl)piperazine-1-carboxylate. This compound has unique chemical properties. The synthetic route is as follows.

(2) 4-phenyl-2-piperazin-1-ylpyrimidine Dihydrochloride To a solution of tert-butyl 4-(4-chloropyrimidin-2-yl)piperazine-1-carboxylate (6.30 g, 20.7 mmol) and phenylboric acid (3.75 g, 31.1 mmol) in anhydrous toluene (250 ml) was added potassium phosphate (9.20 g, 41.5 mmol), 4,5-bis(diphenylphosphino)-9,9-dimethyxanthene (480 mg, 0.83 mmol) and trisdibenzylideneacetone dipalladium (119 mg, 0.21 mmol) under nitrogen atmosphere, and the reaction was degassed and heated under reflux for 14 hours. The reaction was distilled off under reduced pressure and to the residue was added to methylene chloride and water followed by extracted. The extract was washed with saturated brine, dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (petroleum ether:ethyl acetate=5:1) to obtain tert-butyl 4-(4-phenylpyrimidin-2-yl)piperazine-1-carboxylate (5.00 g, 70%).

According to the analysis of related databases, 479691-42-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; US2009/163508; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 479691-42-4, name is tert-Butyl 4-(4-chloropyrimidin-2-yl)piperazine-1-carboxylate. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C13H19ClN4O2

A mixture of tert-butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate (9.00g, 30.1mmol), (2,3-difluorophenyl)boronic acid (7.10g, 45.1mmol), 1M aq Na2CO3 (41 mL, 82.0 mmol), tetrakis(triphenylphosphine)palladium (0) (4.2g, 3.61 mmol), and DME (270 mL) was stirred at 95 C overnight under N2 atmosphere. After cooling to room temperature, the mixture was diluted with water, and extracted with EtOAc. The organic layer was washed with water, dried over anhydrous MgSO4, and concentrated in vacuo. The residue was purified by silica gel column chromatography (hexane-EtOAc) to give 12 (11.3g, quant.) as pale yellow crystals.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 479691-42-4, tert-Butyl 4-(4-chloropyrimidin-2-yl)piperazine-1-carboxylate.

Reference:
Article; Kono, Mitsunori; Matsumoto, Takahiro; Imaeda, Toshihiro; Kawamura, Toru; Fujimoto, Shinji; Kosugi, Yohei; Odani, Tomoyuki; Shimizu, Yuji; Matsui, Hideki; Shimojo, Masato; Kori, Masakuni; Bioorganic and Medicinal Chemistry; vol. 22; 4; (2014); p. 1468 – 1478;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia