Related Products of 494194-61-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.494194-61-5, name is 2,4-Dibromo-5-methylpyrimidine, molecular formula is C5H4Br2N2, molecular weight is 251.91, as common compound, the synthetic route is as follows.
Intermediate 32- IY2-Bromo-5 -methyl-4-pyrimidinyl)amino1 -N-( 1 -methylethvDbenzamideIn a tube were combined Intermediate 1 (4.0 g, 15.9 mmol)), Intermediate 2 (2.8 g, 15.9 mmol), isopropanol (30 mL), and di-isopropyl-ethylamine (3.7 mL, 21.2 mmol). The vessel was sealed and the mixture was heated to 110 0C for 3 days. The reaction mixture was poured onto EtOAc and water. The layers were separated and the aqueous layer was further extracted with more EtOAc. The combined organic layer was washed with brine, dried (MgSO4), filtered and concentrated. Purification by flash chromatography on silica gel (0 – 30% EtOAc/hexanes) afforded the desired product (2.8 g, 50%) as a white solid. LC-MS (ES) m/z = 349, 351 [M+H]+.
The chemical industry reduces the impact on the environment during synthesis 494194-61-5, I believe this compound will play a more active role in future production and life.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2008/147831; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia