Category: 4956-05-02 00:00:00

Pontillo, Joseph; Guo, Zhiqiang; Wu, Dongpei; Struthers, R. Scott; Chen, Chen published the artcile< Synthesis of aryl-1,2,4-triazine-3,5-diones as antagonists of the gonadotropin-releasing hormone receptor>, Electric Literature of 4956-05-2, the main research area is gonadotropin releasing hormone receptor antagonist aryl triazinedione preparation; aza uracil triazinedione preparation preparation gonadotropin releasing hormone receptor.

Several efficient synthetic routes for 2-, 4-, and 6-aryl-1,2,4-triazine-3,5-diones were developed. Derivatives were synthesized and studied as gonadotropin-releasing hormone antagonists in an effort to understand structure-activity relationships of the monocyclic compounds One compound was identified as potent gonadotropin-releasing hormone receptor antagonist from this series.

Bioorganic & Medicinal Chemistry Letters published new progress about Gonadotropin-releasing hormone receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 4956-05-2 belongs to class pyrimidines, and the molecular formula is C3H2BrN3O2, Electric Literature of 4956-05-2.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Jirku, V.; Masak, J.; Cejkova, A. published the artcile< Yeast cell attachment: a tool modulating wall composition and resistance to 5-bromo-6-azauracil>, HPLC of Formula: 4956-05-2, the main research area is yeast attachment cell wall polysaccharide bromoazauracil resistance.

The attachment of Candida utilis, Kluyveromyces lactis, and Saccharomyces cerevisiae cells stimulates an increase in the content of cell wall polysaccharides and mannoproteins, accompanied by increased resistance to the inhibitory effect of 5-bromo-6-azauracil. The covalent attachment of viable yeasts was accomplished (via dialdehyde-amino spacers) by reaction of aldehyde groups of the carrier with reactive amino groups in accessible cell surface proteins. The employed technique enables the optimization of yeast sources of β-1,3-, β-1,6- glucans, mannan, and mannoprotein. The modulatory effect of the cell attachment is discussed.

Enzyme and Microbial Technology published new progress about Bioadhesion. 4956-05-2 belongs to class pyrimidines, and the molecular formula is C3H2BrN3O2, HPLC of Formula: 4956-05-2.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Cristescu, C. published the artcile< as-Triazine derivatives with potential therapeutic action. XIV. Simplified synthesis of 5-substituted 2',3',5'-tri-O-benzoyl-β-D-ribofuranosyl-6-azauracils via 2,4-bis(trimethylsilyloxy) derivatives>, Safety of 6-Bromo-1,2,4-triazine-3,5(2H,4H)-dione, the main research area is azauracil ribofuranosyl; triazine nucleoside; ribofuranosylazauracil; nucleoside azauracil.

The title nucleosides were prepared by condensation of 2,4-bis(trimethylsiloxy)triazine derivatives with 2,3,5-tri-O-benzoyl-D-ribofuranosyl chloride (I) in the presence of Hg(OAc)2. Thus, 5-bromo-6-azauracil was condensed with (Me3Si)2NH and I to give II (R = Bz). Debenzoylation with NaOMe gave II (R = H).

Revue Roumaine de Chimie published new progress about 4956-05-2. 4956-05-2 belongs to class pyrimidines, and the molecular formula is C3H2BrN3O2, Safety of 6-Bromo-1,2,4-triazine-3,5(2H,4H)-dione.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Tzeng, Cherng Chyi; Lee, Kuan Han; Wang, Eng Chi published the artcile< Synthesis of 1-(2-hydroxyethoxymethyl)-6-azauracil and its analogs-potential antiviral agents>, Quality Control of 4956-05-2, the main research area is azauracil hydroxyethoxymethyl preparation virucide potential.

Trimethylsilylation of azauracils I (R = H; R1 = H, Br) followed by coupling reaction with AcO(CH2)2OCH2Br gave I [R = CH2O(CH2)2OAc]. Deacetylation of the latter gave I [R = CH2O(CH2)2OH], which may be potential antiviral agents.

Gaoxiong Yixue Kexue Zazhi published new progress about Antiviral agents. 4956-05-2 belongs to class pyrimidines, and the molecular formula is C3H2BrN3O2, Quality Control of 4956-05-2.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Tzeng, Cherng-Chyi; Hwang, Long-Chih; Chen, Chien-Chi; Wei, Dau-Chang published the artcile< Synthesis of racemic 5-substituted 1-(2,3-dihydroxypropyl)-6-azauracils and their isosteric isomers>, Application In Synthesis of 4956-05-2, the main research area is azauracil acyclic nucleoside synthesis antiviral; hydroxypropylazauracil synthesis antiviral.

Acyclic nucleoside analogs of antiviral DHPA and HPMPA have been prepared Coupling of silylated 6-azauracils with benzyl glycidyl ether and stannic chloride followed by the deprotection with boron trichloride gave 1-(2,3-dihydroxypropyl)-6-azauracils in good overall yields. Reaction of silylated 6-azauracil and epichlorohydrin with or without catalytic stannic chloride afforded 1-(2-chloro-3-hydroxypropyl)-6-azauracil and 1-(3-chloro-2-hydroxypropyl)-6-azauracil resp. Coupling of silylated 6-azaisocytosine under the same reaction conditions provided 1-(2,3-dihydroxypropyl)-6-azaisocytosine and 1-(2-chloro-3-hydroxypropyl)-6-azaisocytosine. None of the compounds exhibited significant antiviral activity against herpes simplex viruses.

Nucleosides & Nucleotides published new progress about Acyclonucleosides Role: BAC (Biological Activity or Effector, Except Adverse), BSU (Biological Study, Unclassified), SPN (Synthetic Preparation), BIOL (Biological Study), PREP (Preparation). 4956-05-2 belongs to class pyrimidines, and the molecular formula is C3H2BrN3O2, Application In Synthesis of 4956-05-2.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Novacek, Alois; Fiedler, Pavel published the artcile< Nucleic acid components and their analogs. CXLI. Reactions of 5-bromo-6-azauracil>, Recommanded Product: 6-Bromo-1,2,4-triazine-3,5(2H,4H)-dione, the main research area is brominated azauracils alk reaction.

The reactions of 5-bromo-1,3-bis(2-cyanoethyl)-6-azauracil (I) and NaOMe or NaOEt or NaOBu was accompanied by a partial decyanoethylation to give the corresponding 5-alkoxy-1-(2-cyanoethyl)-6-azauracils. 5-Bromo-6-azauracil (II), 5-bromo-1-(2-cyanoethyl)-6-azauracil (III), and 5-bromo-3-benzyl-6-azauracil (IV) did not react with sodium alkoxides. 5-Bromo-1,3-dimethyl-6-azauracil refluxed with NaOEt in EtOH gave 5-ethoxy-1,3-dimethyl-6-azauracil. I heated in M NaOH at 90°, the mixture acidified with aqueous HCl, and refluxed with BzH in EtOH gave PhCH:NN(CH2CH2CN)CONHCH2CH2CN. II and IV reacted analogously to I but III was stable to aqueous NaOH. Treatment of 5-bromo-1,3-dibenzyl-6-azauracil with NaOEt in EtOH or with aqueous NaOH gave (by ring contraction) 2,4-dibenzyl-3,4-dihydro-1,2,4-triazol-3-one prepared also by refluxing PhCH:NN(CH2Ph)-CONHCH2Ph in HCO2H. PhCH:NN(CH2Ph)CONH2 refluxed in HCO2H gave PhCH:NN(CHO)CH2Ph. An analogous treatment of PhCH:NNHCONH2 gave (PhCH:N)2.

Collection of Czechoslovak Chemical Communications published new progress about 4956-05-2. 4956-05-2 belongs to class pyrimidines, and the molecular formula is C3H2BrN3O2, Recommanded Product: 6-Bromo-1,2,4-triazine-3,5(2H,4H)-dione.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Piskala, A.; Gut, J.; Sorm, F. published the artcile< Chemistry of 1,2,4-triazine. VIII. Reaction of 3,5,6-trichloro-1,2,4-triazine with simple nucleophiles>, Application of C3H2BrN3O2, the main research area is trichlorotriazine reaction nucleophile; chlorotriazine reaction nucleophile; triazine trichloro reaction nucleophile.

3,5,6-Trichloro-1,2,4-triazine (I) was prepared from 6-bromo-1,2,4-triazine-3,5(2H,4H)-dione and refluxing POCl3. With NH3-MeOH, I gave 5-amino-3,6-dichloro-1,2,4-triazine (II). With 1 mole NaOMe-MeOH or NaHCO3 in aqueous MeOH, I gave 3,6-dichloro-5-methoxy-1,2,4-triazine (III). With 2 moles NaOMe-MeOH, I gave a mixture of 6-chloro-3,5-dimethoxy- (IV) and 3-chloro-5,6-dimethoxy-1,2,4-triazine (V) while with excess NaOMe-MeOH, 3,5,6-trimethoxy-1,2,4-triazine (VI) was obtained. Reaction of III with NH3-MeOH gave II. With NaOMe-MeOH, II gave 5-amino-3-chloro-1,2,4-triazine. With HCl-MeOH, II gave 5-amino-6-chloro-3-methoxy-1,2,4-triazine (VII). Hydrogenolysis of II in dioxane over 10% Pd/C in the presence of N-ethylpiperidine gave a mixture of 5-amino-1,2,4-triazine and 5-amino-3-chloro-1,2,4-triazine. A similar hydrogenolysis of VII gave 5-amino-3-methoxy-1,2,4-triazine. VI refluxed in HCl-MeOH gave 6-methoxy-1,2,4-triazine-3,5(2H,4H)-dione. V was resistant to hydrogenolysis while IV gave 3,5-dimethoxy-1,2,4-triazine. In the above experiments, the positional reactivity of the 1,2,4-triazine ring system decreased in the order 5>3>6 with neutral nucleophiles and in the order 5>6>3 with anionic nucleophiles.

Collection of Czechoslovak Chemical Communications published new progress about Ammonolysis. 4956-05-2 belongs to class pyrimidines, and the molecular formula is C3H2BrN3O2, Application of C3H2BrN3O2.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Mitran, Raul-Augustin; Mihaiescu, Dan; Tomas, Stefan published the artcile< Gas chromatography-mass spectrometry studies of several allyl-substituted 6-azauracil derivatives>, Product Details of C3H2BrN3O2, the main research area is gas chromatog mass spectrometry allyl substituted azauracil derivative identification.

Gas chromatog. coupled with mass spectroscopy was used to study three N-substituted 6-azauracils, alongside 6-azauracil and 5-bromo-6-azauracil. For each compound, the fragmentation patterns are discussed and correlated with proposed fragmentation mechanisms. A loss of isocyanic acid or isocyanate was noticed for all studied azauracil compounds This loss is similar to that found in substituted uracils and may be used for future identification of 6-azauracil derivatives

Revista de Chimie (Bucharest, Romania) published new progress about Fragmentation reaction. 4956-05-2 belongs to class pyrimidines, and the molecular formula is C3H2BrN3O2, Product Details of C3H2BrN3O2.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia