Related Products of 4965-36-0, The chemical industry reduces the impact on the environment during synthesis 4965-36-0, name is 7-Bromoquinoline, I believe this compound will play a more active role in future production and life.
General procedure: Compound 88-1 (7.6 g, 20 mmol) and 2-bromopyridine (4.7 g, 20 mmol) were dissolved in toluene (80 mL), then Pd(PPh3)4 (1.1 g, 1 mmol) and K2CO3 (8.3 g, 60 mmol) were added thereto, and the result was stirred for 10 minutes. After that, H2O (16 mL) and EtOH (16 mL) were added thereto, and the result was refluxed for 12 hours. After the reaction was completed, the result was cooled to room temperature, and extracted with distilled water and Mc. After the organic layer was dried with anhydrous Na2O4, the solvent was removed using a rotary evaporator, and the result was purified using column chromatography with ethyl acetate and hexane as a developing solvent to obtain target Compound 88 (7.3 g, 85%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 7-Bromoquinoline, other downstream synthetic routes, hurry up and to see.