Category: 49844-90-8

Electric Literature of 49844-90-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 49844-90-8, name is 4-Chloro-2-(methylthio)pyrimidine, molecular formula is C5H5ClN2S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

4-Chloro-2-(methylthio)pyrimidine (XII) (19.8 g, 123.4 mmol),Methyl 2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate(III) (34.1 g, 123.4 mmol), tetrakistriphenylphosphine palladium (7.1 g, 6.17 mmol) and sodium carbonate (26.2 g, 246.8 mmol) in toluene (90 mL), methanol (30 mL) and water (30 mL) In the mixed solvent of the composition, under nitrogen protection, the reaction is carried out at 70 C for about 8 h, and the raw materials are to be detected by TLC (petroleum ether: ethyl acetate = 10:1).The reaction was completed, the mixture was cooled to room temperature, ethyl acetate (100 mL) was added, and the mixture was partitioned, and the solvent was evaporated to dryness.Obtained 29.8 g of a white solid, yield: 88.0%

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 49844-90-8, 4-Chloro-2-(methylthio)pyrimidine.

Reference:
Patent; China Pharmaceutical University; Xu Yungen; Ji Dezhong; Zhang Lingzhi; Zhu Qihua; Bai Ying; Wu Yaoyao; (41 pag.)CN109608444; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 49844-90-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 49844-90-8, name is 4-Chloro-2-(methylthio)pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

4-Chloro-2-(methylthio)pyrimidine (24.5g, 153 [MMOL)] was added slowly to [HL] (100 mL, 30% in H2O). The reaction was stirred at RT for about 14 hours. The mixture was neutralized with aqueous NaHCO3. The solid was collected by filtration and dried under vacuum to give the title compound as a white solid (35g, 91 %).

According to the analysis of related databases, 49844-90-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2004/35588; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 49844-90-8, 4-Chloro-2-(methylthio)pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C5H5ClN2S, blongs to pyrimidines compound. Formula: C5H5ClN2S

The crude compound 3 (3.52 mmol) obtained from the previous step was dissolved in DCM (14 ml) and cooled to -5 C. A solution of m-CPBA (1.214 gm) in DCM (14 ml) was added drop wise to the solution of compound 3 at -5C over a period of 30 min. After complete addition, the reaction mixture was allowed to stir at room temperature (RT) for 15 h. On appearance of the white precipitate, it was filtered and washed with cold DCM. The filtrate was washed with 10% K2CO3twice and was dried over anhydrous Na2S04. The solvent was removed to obtain compound 4 as an off-white solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,49844-90-8, 4-Chloro-2-(methylthio)pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; PANDA, Koustubh; NAGPAL, Latika; RANU, Brindaban C.; (45 pag.)WO2018/92034; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia