Category: 49845-33-2

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 49845-33-2, name is 2,4-Dichloro-5-nitropyrimidine, the common compound, a new synthetic route is introduced below. SDS of cas: 49845-33-2

[00510] To a solution of 2,4-dichloro-5-nitropyrimidine (582 mg, 3 mmol) in THF (5 mL) wasadded DIEA (775 mg, 6 mmol) and tert-butyl3-aminophenylcarbamate (625 mg, 3 mmol, in 2mL THF) at -78 °C underN2 atmosphere. After stirring at -78 °C for 30 min, the reaction waswarmed up tor. t. and stirred overnight. The reaction was quenched with water (10 mL) andextracted with IPA/DCM (15:85) (5 mL X 3). The combined organic layer was washed withbrine, and dried over Na2S04. The solvents were removed under vacuum and the residue waspurified by flash chromatography (silica gel, 0 to 5percent ethyl acetate in PE/DCM (Ill) with 0.5percentTEA) to provide tert-butyl 3-(2-chloro-5-nitropyrimidin-4-ylamino )phenylcarbamate (1)(1.087g, 99percent) as an orange solid. LC-MS (ESI) m/z (M/M+2) 366.2/368.2.

The synthetic route of 49845-33-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PHARMACYCLICS, INC.; CHEN, Wei; YAN, Shunqi; LOURY, David, J.; FRYE, Leah, Lynn; GREENWOOD, Jeremy, Robert; SHELLEY, Mee, Yoo; WANG, Longcheng; WO2014/130693; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 49845-33-2, name is 2,4-Dichloro-5-nitropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. category: pyrimidines

Following the preparation protocol of Section 5.1.2.1, the reaction mixtureof 2,4-dichloro-5-nitropyrimidine (1a) (250 mg, 1.29 mmol),DIEA (0.22 mL, 1.29 mmol) and aniline (120 mg, 1.29 mmol) inDCM (1 mL) was stirred at 0 C for 5 min to give the title compound2q as a yellow solid (277 mg, 85.8percent); mp 171?173 C; 1H NMR(400 MHz, DMSO d6) d (ppm) 10.45 (s, 1H), 9.16 (s, 1H), 7.54 (d,J = 8.0 Hz, 2H), 7.45 (t, J = 7.6 Hz, 2H), 7.29 (t, J = 7.2 Hz, 1H); 13CNMR (100 MHz, CDCl3) d (ppm) 164.26, 157.60, 153.44, 135.45,129.30, 126.65, 122.85; HRMS (ESI): m/z, Calcd. for C10H8O2N4Cl[M+H]+: 251.0330, Found 251.0329.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 49845-33-2, 2,4-Dichloro-5-nitropyrimidine.

Reference:
Article; Cui, Guonan; Jin, Jing; Chen, Hualong; Cao, Ran; Chen, Xiaoguang; Xu, Bailing; Bioorganic and Medicinal Chemistry; vol. 26; 8; (2018); p. 2186 – 2197;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 49845-33-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 49845-33-2, name is 2,4-Dichloro-5-nitropyrimidine. A new synthetic method of this compound is introduced below.

2,4-dichloro-5-nitropyrimidine(3g, 15.4 mmol) was dissolved in tetrahydrofuran(52 mL) and 2N methylamine (15.4 mL) dissolved in tetrahydrofuran was slowly added at -78°C. The resulting solution was stirred for 10 minutes and then further stirred for 50 minutes at room temperature. The resulting solution was concentrated under reduced pressure, diluted with ethyl acetate(50 mL), and washed with water (30 mL) and saline (30 mL). The resultant was dehydrated with anhydrous sodium sulfate, concentrated under reduced pressure, and applied to column chromatography (EA : Hex = 20 : 1 ? 5 : 1) to yield Compound XL (925 mg (32percent)). 1H NMR (600MHz, chloroform-d1) delta 9.05(s, 1H), 8.41(br, 1H), 3.23 (d, J = 4.8Hz, 3H),

At the same time, in my other blogs, there are other synthetic methods of this type of compound,49845-33-2, 2,4-Dichloro-5-nitropyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; LegoChem Biosciences, Inc.; CHO, Young Lag; YUN, Joung Yul; PARK, Chul Soon; CHAE, Sang Eun; LEE, Hyang Sook; OH, Kyuman; HEO, Hye Jin; KANG, Dae Hyuck; YANG, Young Jae; KWON, Hyun Jin; PARK, Tae Kyo; WOO, Sung Ho; KIM, Yong Zu; EP2706062; (2014); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 49845-33-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 49845-33-2, name is 2,4-Dichloro-5-nitropyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

2,4-dichloro-5-nitropyrimidine (3 g, 15.4 mmol) was dissolved in tetrahydrofuran (52 mL) and 2N methylamine (15.4 mL) dissolved in tetrahydrofuran was slowly added at -78° C. The resulting solution was stirred for 10 minutes and then further stirred for 50 minutes at room temperature. The resulting solution was concentrated under reduced pressure, diluted with ethyl acetate (50 mL), and washed with water (30 mL) and saline (30 mL). The resultant was dehydrated with anhydrous sodium sulfate, concentrated under reduced pressure, and applied to column chromatography (EA:Hex=20:15:1) to yield Compound XL (925 mg (32percent)).1H NMR (600 MHz, chloroform-d1) delta 9.05 (s, 1H), 8.41 (br, 1H), 3.23 (d, J=4.8 Hz, 3H),

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 49845-33-2, 2,4-Dichloro-5-nitropyrimidine.

Reference:
Patent; Legochem Biosciences, Inc.; US2012/264727; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 49845-33-2 ,Some common heterocyclic compound, 49845-33-2, molecular formula is C4HCl2N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 5 g (25 mmol) 2,4-dichloro-5-nitro-pyrimdine in 150 mL EtOAc was added 50 mL 28-34% aqueous NH4OH. After stirred at rt for 1 hour, the reaction mixture was filtered. The organic layer was concentrated to give desired solid product. 1H NMR (CD3OD): 9.03 (1H, s). LC-MS [M+H]=175.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 49845-33-2, 2,4-Dichloro-5-nitropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Zhu, Song; US2005/250779; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 49845-33-2 ,Some common heterocyclic compound, 49845-33-2, molecular formula is C4HCl2N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a mixture of 2,4-dichloro-5-nitropyrimidine (4) (50.0 g, 258 mmol) and 3*HCl (55.5 g, 284 mmol) in toluene (500 mL) was added NaHCO3 (54.1 g, 644 mmol), and the mixture was stirred at 85-95 C for 3 h under N2 atmosphere. After cooling to room temperature, the mixture was filtered and insoluble matter was washed with toluene (50 mL). To the combined filtrate was added H2O (250 mL), and the layers were separated. To the organic layer were added EtOAc (250 mL) and 1 M HCl (250 mL), and the layers were separated. The organic layer was concentrated in vacuo until the weight of the mixture became approximately 100 g. To this mixture was added 2-propanol (250 mL), and the mixture was concentrated in vacuo again until the weight of the mixture became approximately 100 g. To the resulting mixture were added 2-propanol (200 mL) and seed crystals of 5 (50.0 mg), and the mixture was stirred at 20-30 C for 1 h. The mixture was cooled to 0-10 C and stirred for 1 h, and then filtrated. Wet solids were washed with 2-propanol/H2O (1:1, 100 mL) and dried in vacuo at 50 C to give 5 (59.7 g, 73%) as a yellow solid. Mp 89-91 C; 1H NMR (600 MHz, CDCl3) delta 1.07 (t, J = 7.6 Hz, 3H), 1.31 (d, J = 6.4 Hz, 3H), 1.36 (d, J = 6.4 Hz, 3H), 1.86-2.04 (m, 1H), 2.37-2.56 (m, 1H), 3.55 (dt, J = 13.1, 6.5 Hz, 1H), 3.75 (s, 3H), 3.78 (t, J = 6.8 Hz, 1H), 8.63 (s, 1H); 13C NMR (151 MHz, CDCl3) delta 12.0, 19.5, 21.6, 23.2, 52.5, 53.7, 58.8, 131.0, 153.5, 156.5, 159.4, 170.8; IR (ATR) 1739, 1572, 1543, 1513, 1466, 1439, 1374, 1345, 1311, 1215, 1197, 1180, 1165, 1084, 993, 912, 866, 767, 559, 445 cm-1; HRMS (ESI): [M+H]+ calcd for C12H18ClN4O4, 317.1011; found, 317.1008. Optical purity: 99.9% ee (chiral HPLC condition A).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 49845-33-2, 2,4-Dichloro-5-nitropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ishimoto, Kazuhisa; Nakaoka, Keiichiro; Yabe, Osamu; Nishiguchi, Atsuko; Ikemoto, Tomomi; Tetrahedron; vol. 74; 39; (2018); p. 5779 – 5790;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.49845-33-2, name is 2,4-Dichloro-5-nitropyrimidine, molecular formula is C4HCl2N3O2, molecular weight is 193.9756, as common compound, the synthetic route is as follows.Application In Synthesis of 2,4-Dichloro-5-nitropyrimidine

Example A3 a). Preparation i of intermediate..1.1; A solution of cyclohexanamine (0.062 mol) in iV,JV-dimethylacetamide (20 ml) was added dropwise to a cooled (-100C) solution of 2,4-dichloro-5-nitropyrimidine (0.062 mol) and DIPE (8.1 g) in 7V,7V-dimethylacetamide (80 ml), then the reaction mixture was allowed to reach room temperature overnight, yielding intermediate 11 (contains regio-isomer; used as such in the next reaction steps). EPO

At the same time, in my other blogs, there are other synthetic methods of this type of compound,49845-33-2, 2,4-Dichloro-5-nitropyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2006/74985; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 49845-33-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.49845-33-2, name is 2,4-Dichloro-5-nitropyrimidine, molecular formula is C4HCl2N3O2, molecular weight is 193.9756, as common compound, the synthetic route is as follows.

[00235] Example 5.1 Synthesis of 4-({8-[(2,6-Difluorophenyl)amino]-9- cvclopentylpurin-2-yl) amino) frvms-cyclohexan-l-ol; [00236] 1. (2-Chloro-5-nitropyrimidin-4-yl’)cvclopentylamine; [00237] 2,4-Dichloro-5-nitropyrimidine (10.31 mmol, 2 g) and cyclopentylamine(10.31 mmol, 1.02 mL) were dissolved in THF (60 mL) and cooled to -78C. N5N- diisopropylethylamine (10.31 mmol, 1.8 mL) was added dropwise. The reaction mixture was stirred at -78C for about 45 minutes. The cooling bath was removed and the reaction mixture was stirred at room temperature for about 16 hours. After removal of the solvent the residue was redissolved in EtOAc and washed with water and brine. The organic phase was dried over MgSO4 and the solvent evaporated. The residue was purified using column chromatography (SiO2, 9:1 n-hexanes/ ethyl acetate) to give the desired product (2.11 g, 84% yield). ES-MS: 242 (M+l). When the hydrochloride salt of an amine is used in place of the cyclopentylamine described above, 2 to 3 equivalents of N,N-diisopropylethylamine and dichloromethane are used as solvent.

Statistics shows that 49845-33-2 is playing an increasingly important role. we look forward to future research findings about 2,4-Dichloro-5-nitropyrimidine.

Reference:
Patent; SIGNAL PHARMACEUTICALS, LLC; WO2006/76595; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 49845-33-2, name is 2,4-Dichloro-5-nitropyrimidine, the common compound, a new synthetic route is introduced below. category: pyrimidines

Aqueous ammonia(8.0ml) and N,N-diisopropylethylamine(13.2ml) were dissolved into 150ml dichloromethane. The mixture was added dropwise to a solution of 2,4-dichloro-5-nitropyrimidine(10.0g) in dichloromethane(30ml) at 0C. After the completion of the dropwise addition, the mixture was kept at the same temperature to react for 1 hour. The precipitate was filtered off. The filter cake was recrystallized to obtain a yellow solid(8.1g) in a yield of 90.1%. 1H NMR(400 MHz, DMSO-d6): delta 9.20(s, 1H), 9.02(s, 1H), 8.60(s, 1H)ppm.

The synthetic route of 49845-33-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Si Chuan University; CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; YANG, Shengyong; WEI, Yuquan; EP2578584; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 49845-33-2, name is 2,4-Dichloro-5-nitropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C4HCl2N3O2

Dichloro pyrimidine, 1, (0.34 g, 1.75 mmol) is combined with THF (4 mL) and stirred in an ice/salt water bath under N2 atmosphere. Methylamine (2.0 M in THF, 1.4 mL, 2.8 mmol) is added slowly to the stirring solution. After 10 minutes the mixture is diluted with H2O (20 mL) and extracted with EtOAc (2.x.50 mL). The combined organics are dried over MgSO4 and concentrated. The crude residue is purified over silica (0-10percent. EtOAc/hexanes) to afford 150 mg (46percent yield) or the desired product as a yellow oil. 1H NMR (300 MHz, CDCl3) delta 9.06 (s, 1H), 8.43 (br s, 1H), 3.25 (d, J=5.1 Hz, 3H); ESI/MS: 189 (M+H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 49845-33-2, 2,4-Dichloro-5-nitropyrimidine.

Reference:
Patent; The Procter & Gamble Company; US7256196; (2007); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia