Category: 499195-60-7

Synthetic Route of 499195-60-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.499195-60-7, name is Ethyl 4-(2-chloropyrimidin-4-yl)benzoate, molecular formula is C13H11ClN2O2, molecular weight is 262.69, as common compound, the synthetic route is as follows.

Step 1 : Preperation of ethyl 4-(2-((4-(4-(2-oxopyrrolidin-l-yl)piperidin-l-yl) phenyl) amino) pyrimidin-4-yl)benzoate. To a solution of ethyl 4-(2-chloropyrimidin-4-yl)benzoate (7.09 g, 27.0 mmol), in isopropyl alcohol [100 mL] was added l-(l-(4-aminophenyl)piperidin-4- yl)pyrrolidin-2-one (7.0 g, 27.0 mmol). To this, trifluoro acetic acid (4.62 g, 40.0 mmol) was added and mixture was heated at 120 C in sealed tube for 16 h. After completion of reaction, mixture was quenched in water, basified with ammonia solution and extracted with ethyl acetate. Organic layer was washed with water, dried over sodium sulfate and removed under reduced pressure to give crude off white solid compound. Purification of crude product was done by the way of column chromatography (Si02, hexane to 30 % EtOAc in hexane) to get solid compound (10.7 g, 82%). The title compound was characterized by spectral analysis. ESI-MS: 486.2 (M+H)+.

Statistics shows that 499195-60-7 is playing an increasingly important role. we look forward to future research findings about Ethyl 4-(2-chloropyrimidin-4-yl)benzoate.

Reference:
Patent; CADILA HEALTHCARE LIMITED; DESAI, Ranjit, C.; DESAI, Jigar; PATEL, Pankaj; WO2015/19365; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 499195-60-7, name is Ethyl 4-(2-chloropyrimidin-4-yl)benzoate. This compound has unique chemical properties. The synthetic route is as follows. Safety of Ethyl 4-(2-chloropyrimidin-4-yl)benzoate

Step I : Preparation of ethyl 4-(2-((4-(4-(6-oxa-3-azabicyclo[3.1.1]heptan-3- yl)piperidin- 1 -yl)phenyl)amino)pyrimidin-4-yl)benzoate. Placed ethyl 4-(2-chloropyrimidin-4-yl)benzoate [4.37 g, 16.64 mmol] in rb flask followed by DMA [60 mL]. To this, 4-(4-(6-oxa-3-azabicyclo[3.1.1]heptan-3- yl)piperidin-l-yl)aniline (Amine 17) [3.5 g, 12.80 mmol], cesium carbonate [6.26 g, 19.20 mmol], BINAP [1.19 g, 1.92 mmol] and bis triphenyl phosphie Pd (Il)dichloride [1.34 g, 1.92 mmol] was added at 25C under N2 atm. The mixture was heated to 90C for 16 h. After completion of reaction mixture was quanched in water, compound was extracted with ethyl acetate (50 mL X 4), Combined the organic layers and washed with water and brine soln. The organic layer was dried over Na2S04, filtered and concentrated under reduced pressure to afford desired product as light yellow solid. Title compound was characterised by spectral analysis. ESI-MS : 500.30 (M+H)+.

With the rapid development of chemical substances, we look forward to future research findings about 499195-60-7.

Reference:
Patent; CADILA HEALTHCARE LIMITED; DESAI, Ranjit, C.; DESAI, Jigar; PATEL, Pankaj; WO2015/19365; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia