Extended knowledge of 50593-92-5

The synthetic route of 50593-92-5 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 50593-92-5 , The common heterocyclic compound, 50593-92-5, name is 5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid, molecular formula is C6H5BrN2O2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Preparation 29 (1052) Methyl 5-bromo-2-(methylthio)pyrimidine-4-carboxylate (1053) A solution of 5-bromo-2-(methylthio)pyrimidine-4-carboxylic acid (7.64 g, 30.7 mmol) in MeOH (60 ml_) was treated with sulfuric acid (2 ml_) and heated to reflux for 24 hours. The mixture was poured onto ice water and extracted with DCM. The organic layer was washed with saturated aqueous NaHC03, dried (MgS04) and concentrated in vacuo to afford the title compound (6.42 g, (1054) 80%). (1055) 1 H NMR (500 MHz, CDCb): delta ppm 8.72 (s, 1 H), 4.01 (s, 3H), 2.58 (s, 3H). LCMS (ESI) Rt = 2.35 minutes, MS m/z 263 [M+H]+

The synthetic route of 50593-92-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; WOODWARD, Hannah; INNOCENTI, Paolo; NAUD, Sebastien; BLAGG, Julian; HOELDER, Swen; WO2015/128676; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The origin of a common compound about 50593-92-5

At the same time, in my other blogs, there are other synthetic methods of this type of compound,50593-92-5, 5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.50593-92-5, name is 5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid, molecular formula is C6H5BrN2O2S, molecular weight is 249.09, as common compound, the synthetic route is as follows.Safety of 5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid

A catalytic amount of N,N-dimethylformamide (2 drops) was added to a stirred suspension of 5-bromo-2-(methylthio)pyrimidine-4-carboxylic acid (2.07 g, 8.33 mmol) and a 2 M solution of oxalyl chloride (21 mL, 0.042 mol) in dichloromethane under nitrogen at r.t. Vigorous effervescence was observed. After 30 min everything had dissolved and the solvent was then evaporated in vacuo. The residue was dissolved in dichloromethane (20 mL) and placed under nitrogen. Triethylamine (2.32 mL, 16.66 mmol) was added to this stirred solution at r.t. followed by 4-aminopyridin-3-yl diethylcarbamodithioate (2.01 g, 8.33 mmol). Everything quickly dissolved with a noticeable exotherm. After 3 h at r.t. tic showed a new major product. The reaction was diluted with dichloromethane (20 mL) and washed with a saturated aqueous solution of sodium hydrogen carbonate (40 mL). The organic layer was separated, dried over sodium sulfate, filtered and the solvent evaporated in vacuo. The residue was purified by flash chromatography (ethyl acetate / hexane 15:85 to 60:40) to yield 4-(5-bromo-2- (methylthio)pyrimidine-6-carboxamido)pyridin-3-yl diethylcarbamodithioate (1.99 g, 51%) as a pale yellow amorphous solid. 1H NMR : delta (CDCl3, 400 MHz) 1.30 (t, J = 7 Hz, 3 H), 1.51 (t, J= 7 Hz, 3 H), 2.60 (s, 3 H), 3.93 – 4.08 (m, 4 H), 8.57 – 8.62 (m, 2 H), 8.69 (d, J = 6 Hz, 1 H), 8.85 (s, 1 H), 10.67 (s, 1 H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,50593-92-5, 5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; AMGEN, INC.; WO2006/66172; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

New learning discoveries about 5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 50593-92-5, 5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 50593-92-5, name is 5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid. A new synthetic method of this compound is introduced below., Product Details of 50593-92-5

Acetyl chloride (6.26ml, 0.088mol) was added dropwise at 0-50C to methanol (100ml). The mixture was stirred at 0-50C for 5min. 5-Bromo-2- methylsulfanylpyrimidine-4-carboxylic acid (2Og, O.Odeltamol) was added in portions at 0-50C then the mixture was heated under reflux for Ih, during which time the slurry dissolved, then it was cooled to ambient temperature and poured into saturated aqueous sodium hydrogencarbonate solution (100ml). The product was extracted into dichloromethane (3xl00ml), the extracts were washed with water(100ml), dried (MgSO4) and evaporated in vacuo. The residual solid was crystallised from hexane to give 5-bromo-2-methylsulfanylpyrimidine-4-carboxylic acid methyl ester (12.27g) as an off white crystalline solid, m.pt. 67-700C; 250 MHz 1H-NMR (CDCl3) delta (ppm): 2.6 (s, 3H) (-SCH3), 4.05 (s, 3H) (-OCH3), 8.7 (s, IH) (ArH); m/z (M+H)+’ 249; HPLC purity 96%; HPLC retention time 1.58min.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 50593-92-5, 5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2007/88014; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Simple exploration of 50593-92-5

According to the analysis of related databases, 50593-92-5, the application of this compound in the production field has become more and more popular.

Electric Literature of 50593-92-5, Adding some certain compound to certain chemical reactions, such as: 50593-92-5, name is 5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid,molecular formula is C6H5BrN2O2S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 50593-92-5.

(b). 2-Methylsulfanyl-pyrimidine-4-carboxylic acid; The product of example 21a (517 mg) in methanol (25 ml) was hydrogenated in a PARR apparatus in the presence of KOH (260 mg) and 10% Pd on BaSO4 (260 mg) for4 h. The reaction mixture was filtered over decalite and washed with methanol (warm), The filtrate was concentrated to 50% of its volume followed by addition of cone. HCl(33%) to pH 1. The precipitate (KBr) was filtered off and the mother liquor was concentrated in vacuo. The residue was recrystallized from dioxane. Yield: 200 mg. MS-ESI: [M+H]+ = 170

According to the analysis of related databases, 50593-92-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; N.V. ORGANON; WO2006/117368; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Sources of common compounds: 50593-92-5

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 50593-92-5, 5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid.

Application of 50593-92-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 50593-92-5, name is 5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid, molecular formula is C6H5BrN2O2S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution of 5-bromo-2-(methylthio)pyrimidine-4-carboxylic acid (110 g, 0.44 mol) in methanol (1.1 L) was cooled to 0C with stirreing. Thionyl chloride (50 mL, 0.66 mol) was added dropwise to the solution. The solution was slowly heated and the reaction was conducted under reflux with heating for four hours. The completion of the reaction was monitored by LC/MS and TLC and the solution was cooled to room temperature. The volatiles were distilled away under reduced pressure, and the residue was dissolved in ethyl acetate (1 L). The solution was washed with aqueous 10% sodium carbonate solution (200 mL) three times and with saturated brine (200 mL) twice. The resulting organic phase was dried over anhydrous magnesium sulfate. The solid was filtered out, and the filtrate was concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to give the title compound (88 g, yield: 75%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 50593-92-5, 5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid.

Reference:
Patent; Teijin Pharma Limited; MIZUNO, Tsuyoshi; SHIMADA, Tomohiro; UNOKI, Gen; MARUYAMA, Akinobu; SASAKI, Kosuke; YOKOSAKA, Takuya; TAKAHASHI, Hiroshi; HORIE, Kyohei; SAKAI, Yuri; (181 pag.)EP3546458; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia