Category: 51752-67-1

Related Products of 51752-67-1 ,Some common heterocyclic compound, 51752-67-1, molecular formula is C7H4ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE 43 (3-Chloro-phenyl-pyrido[3,4-d]pyrimidin-4-yl-amine Using a procedure analogous to that described in Example 5, this product was prepared in 37% yield from m-chloroaniline (1.8 eq.) and 4-chloropyrido[3,4-d]pyrimidine (1 eq.). MP 228 C.; LC-MS: 257 (MH+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,51752-67-1, its application will become more common.

Reference:
Patent; Pfizer Inc; US6395733; (2002); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 51752-67-1, name is 4-Chloropyrido[3,4-d]pyrimidine, the common compound, a new synthetic route is introduced below. 51752-67-1

EXAMPLE 24 (3-Ethynyl-phenyl)-pyrido[3,4d]pyrimidin4-yl-amine To 4-chloro-pyrido[3,4-d]pyrimidine (250 mg, 1.50 mmol) in N-methylpyrrolidin-2-one (0.5 mL) was added 3-ethynylaniline (212 mg, 1.81 mmol) and pyridine (237 mg, 3.0 mmol). The mixture was heated to 80 C. under an atmosphere of dry N2(g) for 3 hours. The reaction mixture was dissolved in CHCl3 and washed with saturated aqueous Na2CO3, and brine. The organic phase was dried over Na2SO4, concentrated in vacuo, and flash chromatographed on silica with a gradient of 40% to 70% acetone/hexanes to afford 120 mg of product. This material was precipitated as its hydrochloride salt by dissolution in minimal CHCl3, titration with HCl (1 eq.) in diethyl ether, and dilution with diethyl ether.

The synthetic route of 51752-67-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ARNOLD, LEE DANIEL; MOYER, MIKEL PAUL; SOBOLOV-JAYNES, SUSAN BETH; US2002/45630; (2002); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia