Category: 51870-75-8

Botta, M.’s team published research in Synthetic Communications in 1985 | CAS: 51870-75-8

2-Methoxy-6-methylpyrimidin-4-amine(cas: 51870-75-8) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Safety of 2-Methoxy-6-methylpyrimidin-4-amine

Botta, M.; De Angelis, F.; Finizia, G.; Gambacorta, A.; Nicoletti, R. published an article on January 31 ,1985. The article was titled 《6-Alkyl- and 5,6-dialkyl-2-methoxy-4-(3H)-pyrimidinones in the transformations of pyrimidines. Conversion into 2-substituted amino- and 4-chloropyrimidine derivatives》, and you may find the article in Synthetic Communications.Safety of 2-Methoxy-6-methylpyrimidin-4-amine The information in the text is summarized as follows:

Pyrimidinones I [R = H, Me; R1 = Me, or RR1 = (CH2)4] were converted to amino analogs II (R2 = Bu, cyclohexyl, Ph), and chloropyrimidines III were obtained from I and SOCl2. I (R = H, R1 = Me) was treated with NaH and BuNH2 in tetralin to give II (R = H, R1 = Me, R2 = Bu). In the part of experimental materials, we found many familiar compounds, such as 2-Methoxy-6-methylpyrimidin-4-amine(cas: 51870-75-8Safety of 2-Methoxy-6-methylpyrimidin-4-amine)

2-Methoxy-6-methylpyrimidin-4-amine(cas: 51870-75-8) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Safety of 2-Methoxy-6-methylpyrimidin-4-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Kato, Tetsuo’s team published research in Chemical & Pharmaceutical Bulletin in 1977 | CAS: 51870-75-8

2-Methoxy-6-methylpyrimidin-4-amine(cas: 51870-75-8) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Reference of 2-Methoxy-6-methylpyrimidin-4-amine

In 1977,Chemical & Pharmaceutical Bulletin included an article by Kato, Tetsuo; Oda, Noriichi; Ito, Isoo. Reference of 2-Methoxy-6-methylpyrimidin-4-amine. The article was titled 《Synthesis of compounds related to antitumor agents. VI. The conversion of 2,4-dialkoxypyrimidines into N-dialkyl-1,2,3,4-tetrahydro-2,4-dioxopyrimidines in the presence of p-toluenesulfonic acid derivatives》. The information in the text is summarized as follows:

Twelve 2,4-dialkoxypyrimidines I (R1 = Me, Et, Pr, allyl; R2 = Me, H; R3 = H, Br) were converted into 1,3-dialkyl-1,2,3,4-tetrahydro-2,4-dioxopyrimidines II by heating in the presence of p-MeC6H4SO3H or its derivatives, whereas III under similar conditions gave IV and V. In addition to this study using 2-Methoxy-6-methylpyrimidin-4-amine, there are many other studies that have used 2-Methoxy-6-methylpyrimidin-4-amine(cas: 51870-75-8Reference of 2-Methoxy-6-methylpyrimidin-4-amine) was used in this study.

2-Methoxy-6-methylpyrimidin-4-amine(cas: 51870-75-8) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Reference of 2-Methoxy-6-methylpyrimidin-4-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia