Category: 5193-88-4

Adding a certain compound to certain chemical reactions, such as: 5193-88-4, 4-Chloro-5,6-dimethoxypyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 4-Chloro-5,6-dimethoxypyrimidine, blongs to pyrimidines compound. Safety of 4-Chloro-5,6-dimethoxypyrimidine

b. Preparation of Compound 4-(4-Fluorophenyl)-5,6-dimethoxypyrimidine 4-Chloro-4,5-dimethoxypyrimidine (165 mg, 0.95 mmol), (4-fluorophenyl)boronic acid (99 mg, 1.42 mmol), Pd(PPh3)4 (110 mg, 0.095 mmol) and Na2CO3(300 mg, 2.84 mmol) were dissolved in a mixture of dioxane (9 mL) and water (3 mL). The air was evacuated and replaced with N2. Then, the reaction mixture was refluxed for 19 hours. After the reaction was completed, it was cooled to room temperature and it was diluted with EtOAc and washed with sat. NH4CI followed by brine. The organic layer was dried over Na2S04 and concentrated under reduced pressure and the resulting residue was flash chromatographed on silica gel eluting with 0 to 10% EtOAc/Hexane. This afforded 4-(4-fluorophenyl)-5,6-dimethoxypyrimidine as a white solid (181 mg, 82%); m.p.62-64 C; 1H NMR (400 MHz, CDC13) delta 8.53 (s, 1H), 8.07 (dd, J= 9 Hz, J= 6 Hz, 2H), 7.15 – 7. 1 1 (m, 2H), 4.07 (s, 3H), 3.73 (s, 3H); 13C NMR (100 MHz, CDCI3) delta 163.7 (Jc,F= 249 Hz), 164.0, 154.3, 152.0,139.4, 131.4 (JCF= 8 Hz), 131.3, 115.3 (JC,F = 21 Hz), 60.2, 54.2; 19F NMR (376 MHz, CDC13) 6 -1 1 1.0

The synthetic route of 5193-88-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; LAVOIE, Edmond J.; BAUMAN, Joseph David; PARHI, Ajit; SAGONG, Hye Yeon; PATEL, Disha; ARNOLD, Eddy; DAS, Kalyan; VIJAYAN, Suyambu Kesava; WO2014/43252; (2014); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5193-88-4, name is 4-Chloro-5,6-dimethoxypyrimidine. A new synthetic method of this compound is introduced below., Product Details of 5193-88-4

A solution of 4-chloro-5,6-dimethoxypyrimidine, 1 (5g, 28.64 mmol) in dry methanol (100 mL) was hydrogenated at 1 atm H2 gas pressure using Pd (10%) on carbon (1 g) as catalyst for 3 hours. After completion of the reaction, the reaction mixture was filtered through celite pad and concentrated to dryness to get (4 g, 99 %) of pure 4,5-dimethoxypyrimidine, 2, as a white solid. UPLC = Calculated for C6H8N202 140.14, Observed = 141.1

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Reference:
Patent; FORGE THERAPEUTICS, INC.; NAMMALWAR, Baskar; TENG, Min; TAGANOV, Konstantin; PUERTA, David T.; (132 pag.)WO2017/83431; (2017); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia