Category: 52602-68-3

New learning discoveries about 6-Chloro-N4-methyl-4,5-pyrimidinediamine

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 52602-68-3, 6-Chloro-N4-methyl-4,5-pyrimidinediamine.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 52602-68-3, name is 6-Chloro-N4-methyl-4,5-pyrimidinediamine. A new synthetic method of this compound is introduced below., Recommanded Product: 6-Chloro-N4-methyl-4,5-pyrimidinediamine

General procedure: A mixture of the 4,5-diamino-6-chloro-N4-methylpyrimidine (6, 1mmol), the appropriate arylaldehyde (1.2mmol), acetic acid (2.3mmol) in methanol (4.3mL) was stirred at room temperature for 16h. The reaction mixture was concentrated to dryness under reduced pressure. The residue was azeotropically distilled with toluene (2¡Á4mL) and used directly in the next step. To the suspension in ethanol (6mL) of the crude imine, a solution of anhydrous FeCl3 (1mmol) in ethanol (3mL) was added. The mixture was stirred at 80C for the time stated below for each product. The solvent was removed and the 8-aryl-6-chloro-9-methyl-9H-purines 26-36 were obtained as pure compounds after silica gel flash chromatography and crystallization.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 52602-68-3, 6-Chloro-N4-methyl-4,5-pyrimidinediamine.

Reference:
Article; Lambertucci, Catia; Marucci, Gabriella; Dal Ben, Diego; Buccioni, Michela; Spinaci, Andrea; Kachler, Sonja; Klotz, Karl-Norbert; Volpini, Rosaria; European Journal of Medicinal Chemistry; vol. 151; (2018); p. 199 – 213;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

A new synthetic route of 6-Chloro-N4-methyl-4,5-pyrimidinediamine

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,52602-68-3, its application will become more common.

Synthetic Route of 52602-68-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 52602-68-3 as follows.

General procedure: A mixture of the 4,5-diamino-6-chloro-N4-methylpyrimidine (6, 1mmol), the appropriate arylaldehyde (1.2mmol), acetic acid (2.3mmol) in methanol (4.3mL) was stirred at room temperature for 16h. The reaction mixture was concentrated to dryness under reduced pressure. The residue was azeotropically distilled with toluene (2¡Á4mL) and used directly in the next step. To the suspension in ethanol (6mL) of the crude imine, a solution of anhydrous FeCl3 (1mmol) in ethanol (3mL) was added. The mixture was stirred at 80C for the time stated below for each product. The solvent was removed and the 8-aryl-6-chloro-9-methyl-9H-purines 26-36 were obtained as pure compounds after silica gel flash chromatography and crystallization.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,52602-68-3, its application will become more common.

Reference:
Article; Lambertucci, Catia; Marucci, Gabriella; Dal Ben, Diego; Buccioni, Michela; Spinaci, Andrea; Kachler, Sonja; Klotz, Karl-Norbert; Volpini, Rosaria; European Journal of Medicinal Chemistry; vol. 151; (2018); p. 199 – 213;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia