Category: 52854-14-5

Demina, Galina R.’s team published research in PLoS One in 2009 | CAS: 52854-14-5

4-Chloro-6-methoxy-5-nitropyrimidine(cas: 52854-14-5) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.SDS of cas: 52854-14-5

Demina, Galina R.; Makarov, Vadim A.; Nikitushkin, Vadim D.; Ryabova, Olga B.; Vostroknutova, Galina N.; Salina, Elena G.; Shleeva, Margarita O.; Goncharenko, Anna V.; Kaprelyants, Arseny S. published their research in PLoS One on December 31 ,2009. The article was titled 《Finding of the low molecular weight inhibitors of resuscitation promoting factor enzymatic and resuscitation activity》.SDS of cas: 52854-14-5 The article contains the following contents:

Background: Resuscitation promoting factors (RPF) are secreted proteins involved in reactivation of dormant actinobacteria, including Mycobacterium tuberculosis. They have been considered as prospective targets for the development of new anti-tuberculosis drugs preventing reactivation of dormant tubercle bacilli, generally associated with latent tuberculosis. However, no inhibitors of Rpf activity have been reported so far. The goal of this study was to find low mol. weight compounds inhibiting the enzymic and biol. activities of Rpfs. Methodol./Principal Findings: Here the authors describe a novel class of 2-nitrophenylthiocyanates (NPT) compounds that inhibit muralytic activity of Rpfs with IC50 1-7 μg/mL. Fluorescence studies revealed interaction of active NPTs with the internal regions of the Rpf mol. Candidate inhibitors of Rpf enzymic activity showed a bacteriostatic effect on growth of Micrococcus luteus (in which Rpf is essential for growth protein) at concentrations close to IC50. The candidate compounds suppressed resuscitation of dormant (“”non-culturable””) cells of M. smegmatis at 1 μg/mL or delayed resuscitation of dormant M. tuberculosis obtained in laboratory conditions at 10 μg/mL. However, they did not inhibit growth of active mycobacteria under these concentrations Conclusions/Significance: NPT are the first example of low mol. weight compounds that inhibit the enzymic and biol. activities of Rpf proteins. In the experimental materials used by the author, we found 4-Chloro-6-methoxy-5-nitropyrimidine(cas: 52854-14-5SDS of cas: 52854-14-5)

4-Chloro-6-methoxy-5-nitropyrimidine(cas: 52854-14-5) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.SDS of cas: 52854-14-5

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Ryabova, O. B.’s team published research in Russian Chemical Bulletin in 2005 | CAS: 52854-14-5

4-Chloro-6-methoxy-5-nitropyrimidine(cas: 52854-14-5) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Name: 4-Chloro-6-methoxy-5-nitropyrimidine

Ryabova, O. B.; Khmel’nitskaya, E. Yu.; Makarov, V. A.; Alekseeva, L. M.; Grigor’ev, N. B.; Granik, V. G. published their research in Russian Chemical Bulletin on December 31 ,2005. The article was titled 《4-[(Dialkylthiocarbamoyl)thio]-5-nitropyrimidines as new potential nitric oxide donors》.Name: 4-Chloro-6-methoxy-5-nitropyrimidine The article contains the following contents:

On heating at pH 6.86, the title compounds (I; X = H, Me; R = OMe, OPh, NHMe, NMe2, etc.; NR1R2 = 1-pyrrolidinyl, piperidino, hexahydro-1-azepinyl, NMeEt, etc.) are transformed into dithiolopyrimidines, which are either oxidized to bis(dialkylthiocarbamoylpyrimidin-5-yl) disulfides (II; n = 1, 2, 3) or converted to aminonitropyrimidines (III; n = 1, 2) with carbon disulfide elimination. The direction of the reaction is determined by the nature of the substituent in position 2 of the pyrimidine and the bulk of the thiocarbamate substituent. Mechanistic schemes for these processes are proposed. Refluxing most I in EtOH containing a phosphate buffer (pH 6.86) resulted in degradation to form nitrite anion, a measure of NO-donor ability. In the part of experimental materials, we found many familiar compounds, such as 4-Chloro-6-methoxy-5-nitropyrimidine(cas: 52854-14-5Name: 4-Chloro-6-methoxy-5-nitropyrimidine)

4-Chloro-6-methoxy-5-nitropyrimidine(cas: 52854-14-5) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Name: 4-Chloro-6-methoxy-5-nitropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Brakta, Mohamed’s team published research in Journal of the Chemical Society in 1992 | CAS: 52854-14-5

4-Chloro-6-methoxy-5-nitropyrimidine(cas: 52854-14-5) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Computed Properties of C5H4ClN3O3

Brakta, Mohamed; Daves, G. Doyle Jr. published their research in Journal of the Chemical Society on August 7 ,1992. The article was titled 《Efficient synthesis of 3H,5H-pyrrolo[3,2-d]pyrimidin-4-one》.Computed Properties of C5H4ClN3O3 The article contains the following contents:

Palladium-catalyzed cross-coupling of 4-iodo-6-methoxy-5-nitropyrmidine and trimethyl(tributylstannylethynyl)silane to form the corresponding 4-(trimethylsilylethynyl)pyrimidine I and subsequent construction of an annellated pyrrolo ring II provides an efficient route to the title pyrrolo[3,2-d]pyrimidine system III. In the experiment, the researchers used many compounds, for example, 4-Chloro-6-methoxy-5-nitropyrimidine(cas: 52854-14-5Computed Properties of C5H4ClN3O3)

4-Chloro-6-methoxy-5-nitropyrimidine(cas: 52854-14-5) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Computed Properties of C5H4ClN3O3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Hurst, Derek T.’s team published research in Journal of Heterocyclic Chemistry in 1995 | CAS: 52854-14-5

4-Chloro-6-methoxy-5-nitropyrimidine(cas: 52854-14-5) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Application of 52854-14-5

《Reaction of 4-chloropyrimidines with alkylisothioureas》 was written by Hurst, Derek T.. Application of 52854-14-5 And the article was included in Journal of Heterocyclic Chemistry on April 30 ,1995. The article conveys some information:

Reaction of 4,6-dichloro-5-nitropyrimidine with S-methylisothiouronium sulfate gave 1-(4-chloro-5-nitropyrimidinium-6-yl)-S-methylisothiourea by an unusual nucleophilic attack involving an isothiouronium nitrogen atom. Rearrangement of S-Methylisothiuronium sulfate with 4,6-dichloro-5-nitropyrimidine gave [4-(methylthio)-1,3,5-triazin-2(1H)-ylidene]nitroacetonitrile (>70% yield) and 4,6-bis(methylthio)-5-nitropyrimidine (6% yield). In the experiment, the researchers used many compounds, for example, 4-Chloro-6-methoxy-5-nitropyrimidine(cas: 52854-14-5Application of 52854-14-5)

4-Chloro-6-methoxy-5-nitropyrimidine(cas: 52854-14-5) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Application of 52854-14-5

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Sakamoto, Takao’s team published research in Chemical & Pharmaceutical Bulletin in 1993 | CAS: 52854-14-5

4-Chloro-6-methoxy-5-nitropyrimidine(cas: 52854-14-5) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Category: pyrimidines

Sakamoto, Takao; Satoh, Chisato; Kondo, Yoshinori; Yamanaka, Hiroshi published an article on January 31 ,1993. The article was titled 《Condensed heteroaromatic ring systems. XXI. Synthesis of pyrrolo[2,3-d]pyrimidines and pyrrolo[3,2-d]pyrimidines》, and you may find the article in Chemical & Pharmaceutical Bulletin.Category: pyrimidines The information in the text is summarized as follows:

The title compounds, e.g., I and II were synthesized in high yields by the palladium-catalyzed reaction of 4-acetylamino-5-bromopyrimidines and 5-acetylamino-4-iodopyrimidines with (Z)-1-ethoxy-2-(tributylstannyl)ethene followed by cyclization under acidic conditions.4-Chloro-6-methoxy-5-nitropyrimidine(cas: 52854-14-5Category: pyrimidines) was used in this study.

4-Chloro-6-methoxy-5-nitropyrimidine(cas: 52854-14-5) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Ryabova, O. B.’s team published research in Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya) in 2004 | CAS: 52854-14-5

4-Chloro-6-methoxy-5-nitropyrimidine(cas: 52854-14-5) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Application In Synthesis of 4-Chloro-6-methoxy-5-nitropyrimidine

《Synthesis and thermal transformations of 5-nitropyrimidin-4-yl dialkyldithiocarbamates》 was written by Ryabova, O. B.; Makarov, V. A.; Chernyshev, V. V.; Granik, V. G.. Application In Synthesis of 4-Chloro-6-methoxy-5-nitropyrimidine And the article was included in Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya) on April 30 ,2004. The article conveys some information:

On heating, 5-nitropyrimidin-4-yl dialkyldithiocarbamates undergo two types of transformations. One type of these transformations involves intramol. ipso-substitution of the nitro group to form bis(4-dialkylcarbamoylthiopyrimidin-5-yl) disulfides, whereas another type of transformations involves elimination of carbon disulfide to give 4,6-diamino-5-nitropyrimidine derivatives The reaction pathway is controlled by the steric effect of the substituent at position 6 of the pyrimidine ring.4-Chloro-6-methoxy-5-nitropyrimidine(cas: 52854-14-5Application In Synthesis of 4-Chloro-6-methoxy-5-nitropyrimidine) was used in this study.

4-Chloro-6-methoxy-5-nitropyrimidine(cas: 52854-14-5) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Application In Synthesis of 4-Chloro-6-methoxy-5-nitropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

New learning discoveries about 4-Chloro-6-methoxy-5-nitropyrimidine

Statistics shows that 52854-14-5 is playing an increasingly important role. we look forward to future research findings about 4-Chloro-6-methoxy-5-nitropyrimidine.

Synthetic Route of 52854-14-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.52854-14-5, name is 4-Chloro-6-methoxy-5-nitropyrimidine, molecular formula is C5H4ClN3O3, molecular weight is 189.56, as common compound, the synthetic route is as follows.

General procedure: 4-chloro-6-methoxy-5-nitro-pyrimidine (Preparation R1a; 1.0 eq.), the appropriate phenol (1.2 eq.), and potassium carbonate (1.2 eq.) were dissolved in acetonitrile. It was stirred at 80 C till completion, then water was added to the reaction mixture. MeCN was evaporated. The residue extracted with DCM. The combined organic phase was dried over MgS04 and evaporated under reduced pressure to give R2a-R2ce.

Statistics shows that 52854-14-5 is playing an increasingly important role. we look forward to future research findings about 4-Chloro-6-methoxy-5-nitropyrimidine.

Reference:
Patent; LES LABORATOIRES SERVIER; VERNALIS (R&D) LIMITED; WEBER, Csaba; KOTSCHY, Andras; VASAS, Attila; KISS, Arpad; MOLNAR, Balazs; MACIAS, Alba; FIUMANA, Andrea; DAVIES, Nicholas; MURRAY, James Brooke; SELLIER, Emilie; DEMARLES, Didier; IVANSCHITZ, Lisa; GENESTE, Olivier; (233 pag.)WO2020/8013; (2020); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Brief introduction of 52854-14-5

At the same time, in my other blogs, there are other synthetic methods of this type of compound,52854-14-5, 4-Chloro-6-methoxy-5-nitropyrimidine, and friends who are interested can also refer to it.

Electric Literature of 52854-14-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 52854-14-5, name is 4-Chloro-6-methoxy-5-nitropyrimidine. A new synthetic method of this compound is introduced below.

General procedure: 4-chloro-6-methoxy-5-nitro-pyrimidine (Preparation R1a; 1.0 eq.), the appropriate phenol (1.2 eq.), and potassium carbonate (1.2 eq.) were dissolved in acetonitrile. It was stirred at 80 C till completion, then water was added to the reaction mixture. MeCN was evaporated. The residue extracted with DCM. The combined organic phase was dried over MgS04 and evaporated under reduced pressure to give R2a-R2ce.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,52854-14-5, 4-Chloro-6-methoxy-5-nitropyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; LES LABORATOIRES SERVIER; VERNALIS (R&D) LIMITED; WEBER, Csaba; KOTSCHY, Andras; VASAS, Attila; KISS, Arpad; MOLNAR, Balazs; MACIAS, Alba; FIUMANA, Andrea; DAVIES, Nicholas; MURRAY, James Brooke; SELLIER, Emilie; DEMARLES, Didier; IVANSCHITZ, Lisa; GENESTE, Olivier; (233 pag.)WO2020/8013; (2020); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Some tips on 4-Chloro-6-methoxy-5-nitropyrimidine

The chemical industry reduces the impact on the environment during synthesis 52854-14-5, I believe this compound will play a more active role in future production and life.

Related Products of 52854-14-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.52854-14-5, name is 4-Chloro-6-methoxy-5-nitropyrimidine, molecular formula is C5H4ClN3O3, molecular weight is 189.56, as common compound, the synthetic route is as follows.

General procedure: To a soln. of 1-fluoro/chloro-2-nitro-(hetero)arene (BB-2, 1 eq) and Boc-protected diamine (BB-1 , 1 to 1.2 eq) in DMSO (1.5 mL/mmol) was added DIPEA (2 eq) and the soln. was heated at a given temperature for a given time (see Table 16). The rxn mixture was partitioned between EtOAc and water. The org. phase was washed with water (4x) and with brine, dried over MgS04 and concentrated in vacuo. The crude was purified by CC using Hept/EtOAc and/or DCM/MeOH.

The chemical industry reduces the impact on the environment during synthesis 52854-14-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; IDORSIA PHARMACEUTICALS LTD; FROIDEVAUX, Sylvie; HUBLER, Francis; MURPHY, Mark; RENNEBERG, Dorte; STAMM, Simon; (188 pag.)WO2019/141803; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Some scientific research about 4-Chloro-6-methoxy-5-nitropyrimidine

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 52854-14-5, 4-Chloro-6-methoxy-5-nitropyrimidine.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 52854-14-5, name is 4-Chloro-6-methoxy-5-nitropyrimidine. A new synthetic method of this compound is introduced below., COA of Formula: C5H4ClN3O3

Example 12 4-methoxy-6-dimethyldithiocarbamoyl-5-nitropyrimidine (14) A solution of 4-methoxy-6-chloro-5-nitropyrimidine (0.5 g, 2.6 mmol), sodium dimethyldithiocarbamate dihydrate (0.6 g, 3.3 mmol) and ethanol (40 mL) was mixed for 1 hour at room temperature. Reaction mixture was diluted by water (80 mL), light yellow solid was filtered and purified by crystallization from methanol to give 0.4 g of pure title compound as an bright yellow crystalline solid, m.p. 122-125ØC.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 52854-14-5, 4-Chloro-6-methoxy-5-nitropyrimidine.

Reference:
Patent; MEDAC GmbH; EP1312607; (2003); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia