Category: 52854-14-5

Adding a certain compound to certain chemical reactions, such as: 52854-14-5, 4-Chloro-6-methoxy-5-nitropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 4-Chloro-6-methoxy-5-nitropyrimidine, blongs to pyrimidines compound. Recommanded Product: 4-Chloro-6-methoxy-5-nitropyrimidine

b) 4-Methoxypyrimidin-5-amine 10% Palladium on carbon (1.10 g) was added to a solution of 4-chloro-6-methoxy-5-nitropyrimidine (Preparation 25a, 1.97 g, 10.4 mmol) in ethanol (80 mL) and the reaction mixture was stirred at ambient temperature overnight under a hydrogen atmosphere at a pressure of 2 bars. The mixture was then filtered through Celite and the filter cake was washed with ethanol. The combined filtrate and washings were concentrated to give the title compound (1.30 g, 100%) as a solid. LRMS (m/z): 126 (M+1)+. 1H NMR delta (300 MHz, DMSO-d6): 4.11 (s, 3H), 7.91 (s, 1 H), 8.59 (s, 1 H).

The synthetic route of 52854-14-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Almirall, S.A.; EP2527344; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 52854-14-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 52854-14-5, name is 4-Chloro-6-methoxy-5-nitropyrimidine, molecular formula is C5H4ClN3O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

4-Chloro-6-methoxy-5-nitropyrimidine (0.6g) and 5% Pd on carbon (0.6g) in ethanol(90mL) and under hydrogen (2 bar) was stirred at room temperature for 16h. The mixturewas filtered through a pad of celite and evaporated under reduced pressure to give thesubtitle compound (0.35g).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 52854-14-5, 4-Chloro-6-methoxy-5-nitropyrimidine.

Reference:
Patent; ASTRAZENECA AB; WO2004/108690; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 52854-14-5, name is 4-Chloro-6-methoxy-5-nitropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 4-Chloro-6-methoxy-5-nitropyrimidine

b) 4-Methoxypyrimidin-5-amine10% Palladium on carbon (1 .10 g) was added to a solution of 4-chloro-6-methoxy-5- nitropyrimidine (Preparation 76a, 1 .97 g, 10.4 mmol) in ethanol (80 mL) and the reaction mixture was stirred at ambient temperature overnight under a hydrogen atmosphere at a pressure of 2 bars. The mixture was then filtered through Celite and the filter cake was washed with ethanol. The combined filtrate and washings were concentrated to give the title compound (1 .30 g, 100%) as a solid.LRMS (m/z): 126 (M+1 )+.1H NMR delta (300 MHz, DMSO-d6): 4.1 1 (s, 3H), 7.91 (s, 1 H), 8.59 (s, 1 H).

With the rapid development of chemical substances, we look forward to future research findings about 52854-14-5.

Reference:
Patent; ALMIRALL, S.A.; EASTWOOD, Paul Robert; GONZALEZ RODRIGUEZ, Jacob; GOMEZ CASTILLO, Elena; BACH TANA, Jordi; WO2012/160030; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 52854-14-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 52854-14-5, name is 4-Chloro-6-methoxy-5-nitropyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

The above product (3.50 g, 18.5 mmol) and 3′-aminobiphenyl-2-carbonitrile (prepared according to the procedure described in WO 02/38568) (3.23 g, 16.6 mmol) were dissolved in triethylamine (9. 32 g, 92.3 mmol) and dimethylsulfoxide (10 ml) and heated at 90C for 18 h. The mixture was allowed to cool to ambient temperature then poured onto water (150 ml) and extracted with ethyl acetate (2 x 300 ml). The organic fractions were combined, washed with water (3 x 75 ml) and brine (50 ml), dried over anhydrous sodium sulfate, filtered and evaporated to give a brown solid. The brown solid was triturated with diethyl ether (50 ml), filtered, washed with diethyl ether (2 x 10 ml) and left to air dry, which gave 3′- (1-methyl-5-nitro-6-oxo-1, 6-DIHYDROPYRIMIDIN-4-YLAMINO) biphenyl-2-carbonitrile (2.24 g, 38%) as a yellow solid

According to the analysis of related databases, 52854-14-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK SHARP & DOHME LIMITED; WO2004/41826; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia