Category: 5305-40-8

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5305-40-8, name is 4,6-Dichloropyrimidine-5-carbaldehyde. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 5305-40-8

The compound 4,6-dichloropyrimidine-5-carbaldehyde (5 g, 28.25 mmol) was suspended in dry MeOH (100 mL)After K2CO3 (7.8 g, 56.5 mmol) was added thereto, the reaction mixture was stirred at 90 C for 1 hour and then concentrated under reduced pressure to giveThe residue was dissolved in a mixed solvent of water (100 mL) and DCM (100 mL), separated on a liquid phase, the aqueous phase was extracted with DCM (50 mL ¡Á 3)The combined organic phases were concentrated under reduced pressure, the residue was diluted in DCM / PE (1 mL / 20 mL) and the resulting mixture stirred at room temperatureThe mixture was stirred for 3 hours and then filtered off with suction to give a yellow solid which was purified by silica gel column chromatography (PE / EtOAc (v / v) = 5/1)Purification gave the title compound as a white solid (2.2 g, 46.3%).

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Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; Wang Liang; Wu Zuping; Feng Xuejin; Wu Yanjun; (154 pag.)CN104513235; (2017); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 5305-40-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5305-40-8, name is 4,6-Dichloropyrimidine-5-carbaldehyde. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To the solution of 4,6-dichloropyrimidine-5-carbaldehyde 2 (1.0g, 5.6mmol) in methanol (20mL) at-65C, triethylamine (0.97mL) was added. A solution of hydrazine monohydrate (0.274mL 1.0 eq.) in methanol (10mL) was slowly dripped into above stirred solution by using a constant-pressure dropping funnel. The mixture was allowed to warm to room temperature and stirred for 2-3h. The reaction mixture was concentrated in vacuo and crude product was diluted with water (20mL), and extracted with EtOAc (60mL¡Á3). The combined organic layer was washed with saturated solution of NaCl (60mL¡Á3), dried over MgSO4 and concentrated to give compound 3 (0.602g, yield: 68.9%.) 1H NMR (400MHz, deuteriated dimethyl sulfoxide (DMSO-d6)) delta 14.51 (s, 1H), 8.84 (s, 1H), 8.45 (s, 1H). ESI-MS m/z: 153.00 [M- H]-.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5305-40-8, 4,6-Dichloropyrimidine-5-carbaldehyde.

Reference:
Article; Wang, Yuanyuan; Wan, Shanhe; Li, Zhonghuang; Fu, Yu; Wang, Guangfa; Zhang, Jiajie; Wu, Xiaoyun; European Journal of Medicinal Chemistry; vol. 155; (2018); p. 210 – 228;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia