Category: 54030-56-7

Investigation of the reaction of 6-amino-3-methyl-4-oxo-3,4-dihydro-2-pyrimidinylhydrazine was written by Moustafa, M. A.;Gineinah, M. M.;Bayomi, S. M.;Ismaiel, A. M.. And the article was included in Archives of Pharmacal Research in 1990.Safety of 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one This article mentions the following:

The hydrazine derivative I was utilized for the synthesis of three different fused 1,2,4-triazolo [4,3-a]pyrimidine derivatives II (R = H, R¹ = C₆H₄Cl-p, SH; R = CHO, R¹ = H) and a tetrazolo[1,5-a]pyrimidine derivative III. Reaction of I with the chalcone analog 2-thenylidene-2′-acetothienone, gave the pyrazoline derivative IV. In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Safety of 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one).

6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Safety of 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Aminopyrimidines as electron-rich azadienes: extension of the synthetic potential of hetero Diels-Alder reactions under acidic conditions was written by Garcia, Celeste;Melguizo, Manuel;Cobo, Justo;Sanchez, Adolfo;Nogueras, Manuel;Lopez, Ma Dolores;Low, John N.. And the article was included in Synlett in 2001.SDS of cas: 54030-56-7 This article mentions the following:

By addition of a catalytic amount of a strong acid and selection of the appropriate solvent, the cycloaddition reactions of MeO₂CC濡炪倖鑹鹃幐绀怬₂Me (DMAD) to 6-pyrimidinamines drastically changed their course leading to pyrrolo[3,4-c]pyridines, while, in the absence of acid, 6-amino-3,4-pyridinedicarboxylates were obtained. This change was interpreted on the basis of acid interception of the non-isolable adducts formed by initial hetero Diels-Alder cycloaddition between the reactants. In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7SDS of cas: 54030-56-7).

6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.SDS of cas: 54030-56-7

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Three-component synthesis of hexahydropyridopyrimidine-spirocyclohexanetriones induced by microwave was written by Quiroga, Jairo;Cruz, Silvia;Insuasty, Braulio;Abonia, Rodrigo;Nogueras, Manuel;Cobo, Justo. And the article was included in Tetrahedron Letters in 2006.Electric Literature of C6H9N3OS This article mentions the following:

Spiro pyridopyrimidinone cyclohexanediones and pyrimido[4,5-b]quinolinones were obtained in a three-component microwave-assisted reaction of 6-aminopyrimidin-4-ones with dimedone and formaldehyde solution or paraformaldehyde, resp. A mechanism is proposed based on the presence of a basic catalyst (Et₃N in this case) and the fact that single condensation intermediates are isolated prior to the cyclization leading to the final products. In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Electric Literature of C6H9N3OS).

6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Electric Literature of C6H9N3OS

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Novel procedure for selective C-nitrosation of aminopyrimidine derivatives under neutral conditions. Scope and synthetic applications was written by Marchal, Antonio;Melguizo, Manuel;Nogueras, Manuel;Sanchez, Adolfo;Low, John N.. And the article was included in Synlett in 2002.Name: 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one This article mentions the following:

A novel simple method, based on treatment with isoamyl nitrite (IAN) in DMSO without any added acid, to produce selective C(5)-nitrosation of aminopyrimidine derivatives is described. It proved to be suitable for a multigram scale and applicable to a larger range of pyrimidine derivatives, including aminodialkoxypyrimidines, than the procedures previously known. Its scope is analyzed and some examples on the usefulness of the newly prepared substances as intermediates in the synthesis of fused heterobicyclic derivatives of potential biol. interest are presented. In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Name: 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one).

6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Name: 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

4-aminopyrimidine-5-carbaldehydes as intermediates in a Friedlander-type synthesis of 7-arylpyrido[2,3-d]pyrimidines was written by Quiroga, Jairo;Trilleras, Jorge;Abonia, Rodrigo;Insuasty, Braulio;Nogueras, Manuel;Cobo, Justo;de la Torre, Jose M.. And the article was included in ARKIVOC (Gainesville, FL, United States) in 2009.HPLC of Formula: 54030-56-7 This article mentions the following:

A study of formylation of 6-aminopyrimidines leads to the conclusion that the formylation at C5 occurs only when there is no contribution of heteroaromaticity in the pyrimidine ring and that the corresponding pyrimidoformamides are formed in heteroaromatic pyrimidines. Once 4-aminopyrimidin-4(3H)-one-5-carboxaldehydes were prepared, a series of 7-arylpyrido[2,3-d]pyrimidines derivatives were synthesized by a Friedlander type reaction with acetophenones under solvent-free conditions and in the presence of BF₃閻犺櫣鏋巘₂O. The yields of 7-arylpyrido[2,3-d]pyrimidines range from moderate to good and the reaction times were quite short. In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7HPLC of Formula: 54030-56-7).

6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.HPLC of Formula: 54030-56-7

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthesis of novel pyrimido[4,5-b]quinolin-4-ones with potential antitumor activity was written by Insuasty, Braulio;Becerra, Diana;Quiroga, Jairo;Abonia, Rodrigo;Nogueras, Manuel;Cobo, Justo. And the article was included in Journal of Heterocyclic Chemistry in 2013.Recommanded Product: 54030-56-7 This article mentions the following:

5,6,7,8,9,10-Hexahydro-2-(methylthio)pyrimido[4,5-b]quinolines and their oxidized forms, the corresponding 6,7,8,9-tetrahydropyrimido[4,5-b]quinolin-4(3H)-ones, were obtained from the reaction of 6-amino-2-(methylthio)pyrimidin-4(3H)-one or its 3-Me derivative and 濞?閻?unsaturated ketones using BF₃.OEt₂ as catalyst and 4-chloranil as oxidizing agent. Some of the new compounds were evaluated in the US National Cancer Institute (NCI), where (9E)-9-benzylidene-3-methyl-2-(methylthio)-5-phenyl-5,6,7,8,9,10-hexahydropyrimido[4,5-b]quinolin-4(3H)-one presented remarkable activity against cancer cell lines, with the most important GI₅₀ values of 0.72-18.4 婵炴挾鎷?from in vitro assays. In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Recommanded Product: 54030-56-7).

6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Recommanded Product: 54030-56-7

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reactivity of pyrimidinylphosphazenes with acetylenic esters: Competitive [4 + 2] and [2 + 2] tandem cycloaddition or retro-cycloaddition approaches was written by Cobo, Justo;Molina, Sebastian;Sanchez, Adolfo;Nogueras, Manuel;Insuasty, Braulio;Orozco-Lopez, Fabian. And the article was included in Journal of Heterocyclic Chemistry in 2022.Related Products of 54030-56-7 This article mentions the following:

In the search for new intermediates for heterocyclic synthesis, the reactivity of 6-iminophosphoranepyrimidines against di-Me acetylenedicarboxylate (DMAD) and Et propiolate as dienophiles, was studied. The presence of a viable 2-azadienic moiety in pyrimidin-4-one rings (oxo derivatives) favored reaction of DMAD by [4 + 2]/retro-[4 + 2] sequence, in addition to the expected [2 + 2] cycloaddition/retrocycloaddn. involving phosphazene moiety. In contrast, pyrimidine derivatives lacking a viable 2-azadienic residue reacted only through phosphazene group by the aforementioned [2 + 2]/retro-[2 + 2] tandem process. Et propiolate (nonsym. dienophile) proved less reactive giving rise to undesired side reactions. In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Related Products of 54030-56-7).

6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Related Products of 54030-56-7

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

A facile three-components, one-pot synthesis of pyrimido[4,5-d]pyrimidine-2,5-dione derivatives under microwave-assisted conditions was written by Dabiri, Minoo;Arvin-Nezhad, Hamid;Khavasi, Hamid R.;Bazgir, Ayoob. And the article was included in Journal of Heterocyclic Chemistry in 2007.HPLC of Formula: 54030-56-7 This article mentions the following:

Pyrimido[4,5-d]pyrimidine-2,5-dione derivatives were synthesized in high yields in a novel, 1-pot, and efficient process by condensation of 6-amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one, aldehydes and urea under microwave-assisted conditions. In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7HPLC of Formula: 54030-56-7).

6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.HPLC of Formula: 54030-56-7

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

A novel reaction of 6-aminouracils and isatins was written by Dabiri, Minoo;Azimi, Seyyedeh Cobra;Khavasi, Hamid Reza;Bazgir, Ayoob. And the article was included in Tetrahedron in 2008.Product Details of 54030-56-7 This article mentions the following:

A simple and novel cyclocondensation reaction of 6-aminouracils and isatins for the synthesis of spiro[pyrimido[4,5-b]quinoline-5,5′-pyrrolo[2,3-d]pyrimidine] derivatives, e.g., I, is reported. I was subjected to x-ray anal. In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Product Details of 54030-56-7).

6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Product Details of 54030-56-7

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Investigation in the pyrimidine series V. Acylation of 6-amino-4-oxodihydropyrimidines was written by Pfleiderer, Wolfgang;Liedek, Egon. And the article was included in Justus Liebigs Annalen der Chemie in 1957.Synthetic Route of C6H9N3OS This article mentions the following:

Acylation in the 6-amino-4-oxodihydropyrimidine system occurred in normal fashion on the amino group, as determined by synthesis and by ultraviolet spectral data. NH.CS.NH.CO.CH:CNH₂ (I) (14.3 g.) dissolved in 140 cc. H₂O and 14 cc. concentrated NH₄OH by warming, 42 g. Raney Ni added portionwise at 80鎺? the mixture refluxed 3 hrs., filtered hot, the filtrate kept several hrs. in the refrigerator, the precipitate (II) filtered off, the filtrate concentrated to furnish a 2nd fraction (III), and II and III combined and recrystallized from H₂O gave 6.7 g. N:CH.NH.CO.CH:CNH₂ (IV), m. 271-2鎺?(decomposition). IV (5 g.) and 50 cc. Ac₂ refluxed 30 min., cooled, and the precipitate collected (addnl. material by concentrating the filtrate) and recrystallized from H₂O gave 5.4 g. 6-AcNH analog (V), m. 288-9鎺? I (57 g.) in 600 cc. 2N NaOH treated slowly at 40鎺?with 150 cc. Me₂SO₄ with stirring (a pH of 9 maintained toward the end of the methylation), the precipitate filtered off after 6 hrs., dried, digested with Et₂O, filtered off, and recrystallized from H₂O gave 48 g. N:C(SMe).NMe.CO.CH:CNH₂ (VI), m. 257鎺? VI (17.1 g.) and 120 cc. Ac₂O refluxed 30 min., cooled, the precipitate collected, and recrystallized from aqueous EtOH gave 9.2 g. 6-AcNH analog (VII), m. 251鎺? To 17.1 g. VI in 400 cc. H₂O was added 17.1 g. Raney Ni at 80鎺? refluxed 3.5 hrs., filtered hot, the filtrate concentrated to 1/3 its volume, the concentrate kept several hrs. in the refrigerator, the precipitate filtered off, and recrystallized from H₂O to give 6.5 g. N:CH.NMe.CO.CH:CNH₂ (VIII), m. 184-5鎺? III (3.7 g.) in 25 cc. 2N NaOH treated dropwise at 40鎺?with 5 cc. Me₂SO₄ with stirring while maintaining a pH of 9 at all times, the mixture neutralized with AcOH, extracted continuously 8 hrs. with CHCl₃, the extract dried, evaporated, and the residue recrystallized from H₂O gave 1.3 g. VIII. V (3.8 g.) in 40 cc. N NaOH treated as above with 4 cc. Me₂SO₄ gave 2.1 g. N:CH.NMe.CO.CH:CNHAc (IX), m. 303-4鎺? VIII (4.1 g.) and 20 cc. Ac₂O refluxed 15 min., cooled, the precipitate filtered off, and crystallized from H₂O gave 3 g. IX. VII (7.1 g.) in 200 cc. H₂O treated portionwise with 50 g. Raney Ni, refluxed 4 hrs., filtered hot, the filtrate concentrated to 1/3 its volume, cooled, the precipitate collected, and crystallized from H₂O gave 4.5 g. IX. N:CS.NH.CO.CMe:CNH₂ (15.7 g.) in 200 cc. H₂O treated with 45 g. Raney Ni, refluxed 4 hrs., filtered hot, the filtrate cooled several hrs. in ice, and the precipitate crystallized from H₂O gave 10 g. N:CH.NH.CO.CMe:CNH₂ (X), m. 243鎺? X (3.1 g.) and 9 cc. Ac₂O refluxed 15 min., cooled, and the precipitate recrystallized from H₂O gave 2 g. 6-AcNH analog, m. 303鎺? In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Synthetic Route of C6H9N3OS).

6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Synthetic Route of C6H9N3OS

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia