Synthetic Route of 54198-72-0 ,Some common heterocyclic compound, 54198-72-0, molecular formula is C7H10N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Synthesis of 2-(chloromethyl)-4, 6-dimethylpyrimidine: [0593] To a stirred solution of (4, 6-dimethylpyrimidin-2-yl) methanol (285 mg, 2.06 mmol) in chloroform (8 mL) under argon atmosphere was added phosphoryl chloride (792 mg, 5.16 mmol) at 0 C; heated to 65 C and stirred for 3 h. The reaction was monitored by TLC; after completion of the reaction, the reaction mixture was neutralized with saturated sodium bicarbonate solution (15 mL) and extracted with CH2CI2 (2 x 25 mL). The combined organic extracts were dried over sodium sulphate, filtered and concentrated in vacuo to obtain the crude 2-(chloromethyl)-4, 6- dimethylpyrimidine (225 mg, 68%) as semi solid. The crude was carried to the next step without any further purification. [0594] 1H-NMR (CDCI3, 400 MHz): delta 7.48 (s, 1H), 5.00 (s, 2H), 2.8 (s 6H); LC- MS: 88.37%; 157 (M++l); (column: X Bridge C-18, 50 3.0 mm, 3.5 mupiiota); RT 2.05 min. 0.05% TFA in water: ACN; 0.8 mL/min); TLC: 20% EtOAc/ Hexanes (R/. 0.7)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 54198-72-0, (4,6-Dimethylpyrimidin-2-yl)methanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ENVIVO PHARMACEUTICALS, INC.; RIPKA, Amy; SHAPIRO, Gideon; MCRINER, Andrew, J.; BURSAVICH, Matthew, Gregory; WO2013/142269; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia