Category: 54535-00-1

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 54535-00-1, name is (5,7-Dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methanol. A new synthetic method of this compound is introduced below., Recommanded Product: (5,7-Dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methanol

Under ice bath, intermediate b3 (2.0 g, 11.0mmol) was solubilized in dichloromethane (10 mL). a solution ofthionyl chloride (12.0 mmol) in dichloromethane (10 mL) wasadded drop-wise. The mixture was stirred at rt for 3 h. After that,the solvent was removed under reduced pressure and ethyl acetatewas added, then the mixture was washed by saturated sodiumbicarbonate solution followed by brine, and dried with Na2SO4, filteredand evaporated in vacuo to get yellow solid (1.9 g, 89%). MS[M+H]+ m/z: 197.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 54535-00-1, (5,7-Dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methanol.

Reference:
Article; Liu, Moyi; Xu, Qiaoling; Guo, Su; Zuo, Ruixi; Hong, Yue; Luo, Yong; Li, Yingxiu; Gong, Ping; Liu, Yajing; Bioorganic and Medicinal Chemistry; vol. 26; 9; (2018); p. 2621 – 2631;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.54535-00-1, name is (5,7-Dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methanol, molecular formula is C8H10N4O, molecular weight is 178.19, as common compound, the synthetic route is as follows.Recommanded Product: 54535-00-1

A slurry of 5, 7-DIMETHYL- [1, 2,4] triazolo [1,5-a] pyrimidin-2-yl)-methanol (0.3 g, 1.7 mmol) from Step 2 above and IBX (1.4 G, 5.0 mmol) in 1, 2-dichloroethane (22 mL) was stirred at 80 C for 18 hours. The reaction was cooled to room temperature, and diluted with 100 mL CH2CI2. After the solids were removed by filtration, the solvent was removed by rotary evaporation to give a yellow solid. The solid was purified by flash chromatography to give the desired product (229 mg, 77% yield). H NMR (CDCI3) 8 : 2.72 (s, 3H), 2.86 (s, 3H), 6.96 (s, 1H), 10.24 (s, 1H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,54535-00-1, (5,7-Dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; PFIZER INC.; WO2004/74270; (2004); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia