Category: 55084-66-7

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 55084-66-7, name is 4-Chloro-2-(methylthio)pyrimidine-5-carbonyl chloride, molecular formula is C6H4Cl2N2OS, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: pyrimidines

To a mixture of 4-chloro-2-methylsulfanylpyrimidine-5-carbonyl chloride prepared above (113 mg, 0.54 mmol) in dichloromethane was added 4-fluoroaniline (56 muL, 0.59 mmol). This was followed by the dropwise addition of DIPEA. The mixture was stirred for 15 min, the mixture was diluted with dichloromethane, washed with water and saturated aqueous sodium bicarbonate and was dried over sodium sulfate. Filtration and concentration afforded a residue that was purified by trituration from ethyl acetate with hexanes. The resulting off-white solid (122 mg, 0.41 mmol, 76%) was sufficiently pure to use without further purification. 1H NMR (300 MHz, DMSO-d6) delta 10.7 (s, 1H), 8.86 (s, 1H), 7.69 (m, 2H), 7.23 (m, 2H), 2.56 (s, 3H); MS (EI) m/z 296.2 (M-H)-.

With the rapid development of chemical substances, we look forward to future research findings about 55084-66-7.

Reference:
Patent; UCB SA; US7176310; (2007); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 55084-66-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 55084-66-7, name is 4-Chloro-2-(methylthio)pyrimidine-5-carbonyl chloride. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 4-chloro-2- (methylthio) pyrimidine-5-carbonyl chloride (35 g, 157 mmol) and Amberlyst A21 (6 g, 149 mmol) in ethyl acetate (250 mL) was heated to 40 C followed by the dropwise addition of a solution of 2,6-dichloroaniline (24.21 g, 149 mmol) in ethyl acetate (250mL) . The reaction mixture was heated at 40 C under a nitrogen atmosphere overnight. The resulting suspension was allowed to cool to room temperature and filtered. The isolated solids were taken up in hot tetrahydrofuran (100 mL) and filtered, repeating the process with theundissolved solid a further two times until most of the solid was dissolved. The combined filtrates were concentrated to dryness under reduced pressure to give a pale yellow solid. This was slurried in dichloromethane (100 mL) to give the title compound as a white solid(22.1 g, 42%) . ?H NMR (300 MHz, DMSO-d6) : 3 10.71 (s, 1H),8.82 (s, 1H), 7.62 (d, 2H), 7.43 (t, 1H), 2.60 (s, 3H) LCMS (Method C) : = 1.46 mm, m/z = 348 [M+H].

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 55084-66-7, 4-Chloro-2-(methylthio)pyrimidine-5-carbonyl chloride.

Reference:
Patent; ALMAC DISCOVERY LIMITED; HARRISON, Timothy; TREVITT, Graham; HEWITT, Peter Robin; O’DOWD, Colin Roderick; BURKAMP, Frank; WILKINSON, Andrew John; SHEPHERD, Steven D.; MIEL, Hugues; WO2015/92431; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia