Category: 55583-59-0

Application of 55583-59-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 55583-59-0, name is 2,5-Diamino-4,6-dichloropyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 2 Preparation of N-(2-amino-4,6-dichloropyrimidin-5-yl)-formamide 2,5-Diamino-4,6-dichloropyrimidine (0.01 mol; 2.0 g) and water (0.25 mol; 4.55 ml) were stirred at room temperature. 98% strength formic acid (0.4 mol; 18.27 g; 14.97 ml) was then added to the reaction. The reaction was subsequently heated to 50-55 C. and kept at this temperature for 3 h. Toluene (0.38 mol; 34.6 g; 40 ml) was then added for the azeotropic distillation under high vacuum at 50 C. (toluene was added twice to guarantee a good distillation, i.e. a total of 80 ml). The product was subsequently filtered, washed with water and then dried at 60 C. in vacuo. 0.01 mol (2.0 g) of the abovementioned product was obtained, corresponding to a yield of about 90%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 55583-59-0, 2,5-Diamino-4,6-dichloropyrimidine.

Reference:
Patent; Lonza AG; US6271376; (2001); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 55583-59-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 55583-59-0, name is 2,5-Diamino-4,6-dichloropyrimidine, molecular formula is C4H4Cl2N4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

In the reaction vessel,4,6-Dichloropyrimidine-2,5-diamine(1.00 g, 5.59 mmol), phenylboronic acid(0.681 g, 5.59 mmol), sodium carbonate(2.96 g, 27.9 mmol), and tetrakis(Triphenylphosphine) palladium (0) (323 mg, 0.279 mmol) in toluene (56 mL),Ethanol (14 mL) and distilled water (14 mL)The reaction mixture was cooled to room temperature after stirring for 20 hours under heating reflux conditions under argon atmosphere.Distilled water (6 mL) was added and stirred, and the separated aqueous layer was extracted three times with ethyl acetate (20 mL). Thereafter, the total amount of organic layers is combined, saturated aqueous sodium chloride solution (20 mL) is added thereto, the mixture is stirred for washing, and the separated organic layer is dehydrated by adding anhydrous sodium sulfate,The filtrate after filtration was concentrated under reduced pressure. The concentrate thus obtained is purified by flash column chromatography (silica gel, n-hexane / ethyl acetate),4-Chloro-6-phenylpyrimidine-2,5-diamine was obtained(590 mg, 48% yield).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 55583-59-0, 2,5-Diamino-4,6-dichloropyrimidine.

Reference:
Patent; Microbial Chemistry Research Foundation; Kumagai, Naoya; Noda, Hidetoshi; Asada, Yasuko; Shibazaki, Masakatsu; (48 pag.)JP2019/64981; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 55583-59-0, name is 2,5-Diamino-4,6-dichloropyrimidine, the common compound, a new synthetic route is introduced below. Formula: C4H4Cl2N4

In the reaction vessel, 4,6-dichloropyrimidine-2,5-diamine(501 mg, 2.79 mmol),Benzofuran-2-boronic acid (1.05 g, 6.46 mmol),Sodium carbonate (1.48 g, 14.0 mmol),And tetrakis (triphenylphosphine) palladium (0)To a solution of (161 mg, 0.140 mmol) in toluene (28 mL), ethanol (7 mL) and distilled water (7 mL) are added at room temperature, and the reaction solution is stirred under an argon atmosphere for 20 hours under heat reflux Was cooled to room temperature. Add distilled water (8 mL) and stir,The separated aqueous layer was extracted three times with ethyl acetate (12 mL).Thereafter, the whole organic layer is combined, saturated aqueous sodium chloride solution (12 mL) is added thereto, the mixture is stirred and washed, anhydrous sodium sulfate is added to the separated organic layer for dehydration, and the filtrate after filtration is concentrated under reduced pressure. Flash column chromatography of the obtained concentratePurified with (silica gel, n-hexane / ethyl acetate),4,6-Di (benzofuran-2-yl) pyrimidine-2, 5-diamine(0.748 g, 78% yield)

The synthetic route of 55583-59-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Microbial Chemistry Research Foundation; Kumagai, Naoya; Noda, Hidetoshi; Asada, Yasuko; Shibazaki, Masakatsu; (48 pag.)JP2019/64981; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 55583-59-0, 2,5-Diamino-4,6-dichloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 55583-59-0, blongs to pyrimidines compound. name: 2,5-Diamino-4,6-dichloropyrimidine

To (1 S,4H)-4-amino-2-cyclopentene-1 -methanol tartrate salt (1 g, 4 mmol) in n- BuOH (10 mL) was added 2,5-diamino-4,6-dichloropyrimidine (DADCP, 0.69 g, 4 mmol) and NaHCOs (1 .12 g, 13 mmol) and the mixture was allowed to stir for 16 hr at 95 C. The mixture was cooled and filtered under vacuum. The resulting solvent from the filtrate was removed in vacuo. The crude product was purified by column chromatography (1 :49 to 1 :24 MeOH-DCM) to yield the title compound (0.52 g, 53%) as a pale brown solid, m.p.: 157-159 C (lit. m.p. 158.5- 160.5 C) (29). 1 H NMR (MeOD): delta 5.87 (ddd, J = 5.5, 2.0, 1 .9 Hz, 1 H), 5.80 (ddd, J = 5.6, 2.0, 2.0 Hz, 1 H), 5.07-5.15 (m, 1 H), 3.47-3.56 (m, 1 H), 3.28 (dt, J = 3.2, 1 .6 Hz, 1 H), 2.79-2.83 (m, 1 H), 2.53 (ddd, J= 13.4, 6.4, 6.4 Hz, 1 H), 1 .36 (ddd, J= 13.4, 6.3, 5.9 Hz, 1 H). 13C NMR (MeOD): delta 158.2, 157.3, 143.2, 135.8, 133.9, 1 14.4, 66.4, 57.8, 57.7, 35.8. m/z (ES+) 256.0955 calculated for CioHi5N5035CI: [M+H]+ 256.0965 and 258.0928 calculated for Ci0Hi5N5O37CI: [M+H]+ 258.0936. IR (cm 1): 3451 (N-H), 3324 (N-H), 3125 (br, O-H), 2931 (C-H), 1570 (C=C aromatic), 1430 (CH2), 690 (C-CI).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,55583-59-0, its application will become more common.

Reference:
Patent; THE UNIVERSITY OF LIVERPOOL; O’NEILL, Paul; BERRY, Neil; (52 pag.)WO2017/21716; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 55583-59-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 55583-59-0, name is 2,5-Diamino-4,6-dichloropyrimidine. A new synthetic method of this compound is introduced below.

In a reaction vessel, 4,6-dichloropyrimidine-2,5-diamine (358 mg, 2.00 mmol), 5′-m-terphenylboronic acid (1.22 g, 4.45 mmol), sodium carbonate (1.06 g) Add ethanol (5 mL) and distilled water (5 mL) to a solution of 10.0 mmol) and tetrakis (triphenylphosphine) palladium (0) (116 mg, 0.100 mmol) in toluene (20 mL) at After stirring for 20 hours under heating and reflux conditions under an argon atmosphere, the reaction solution was cooled to room temperature. Distilled water (5 mL) was added and stirred, and the separated aqueous layer was extracted three times with ethyl acetate (10 mL). Thereafter, the whole organic layer is combined, saturated aqueous sodium chloride solution (10 mL) is added thereto, the mixture is stirred and washed, anhydrous sodium sulfate is added to the separated organic layer for dehydration and the filtrate after filtration is concentrated under reduced pressure The The concentrate thus obtained is purified by flash column chromatography (silica gel, n-hexane / ethyl acetate),4,6-Di ([1,1 ‘: 3′, 1′-terphenyl] -5’-yl) pyrimidine-2,5-diamine(1.01 g, 90% yield).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,55583-59-0, 2,5-Diamino-4,6-dichloropyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Microbial Chemistry Research Foundation; Kumagai, Naoya; Noda, Hidetoshi; Asada, Yasuko; Shibazaki, Masakatsu; (48 pag.)JP2019/64981; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 55583-59-0, 2,5-Diamino-4,6-dichloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyrimidines, blongs to pyrimidines compound. category: pyrimidines

General Procedure 1.1 Preparation of 4-alkylamino-6-chloro-2,5-diamine-pyrimidine A suspension of 4,6-dichloro-pyrimidine-2,5-diamine (31.4 mmol), diisopropylethylamine (175 mmol), and R5R4-NH2 (29.5 mmol) in n-BuOH (300 ml), was heated to 115 C. for 6 hours. After removal of the solvent, EtOAc was added to the residue, and it washed with water, brine and dried with Na2SO4 and purified by flash chromatography to give the 4-Alkylamino-6-chloro-2,5-diamine-pyrimidine.; Example 1 6-chloro-N4-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)pyridine-2,4,5-triamine The title compound was prepared by condensation between 4,6-dichloro-pyrimidine-2,5-diamine and 2-aminomethyl-3,5-dimethyl-4-methoxy-pyridine according to the general procedure 1.1 HPLC 3.52 min. 1H-NMR (CDCl3): delta 8.24 (s, 1H), 7.12 (br s, 1H), 4.61 (s, 2H), 4.555 (d, 2H), 3.80 (s, 3H), 3.0 (s, 2H), 2.29 (s, 3H), 2.27 (s, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,55583-59-0, 2,5-Diamino-4,6-dichloropyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; CONFORMA THERAPEUTICS CORPORATION; US2007/253896; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia