Category: 56-05-3

Bennett, Frank published the artcilePyridofuran substituted pyrimidine derivatives as HCV replication (replicase) inhibitors, Related Products of pyrimidines, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(15), 5144-5149, database is CAplus and MEDLINE.

Introduction of nitrogen atom into the benzene ring of a previously identified HCV replication (replicase) benzofuran inhibitor I (X = CH), resulted in the discovery of the more potent pyridofuran analog I (X = N). Subsequent introduction of small alkyl and alkoxy ligands into the pyridine ring resulted in further improvements in replicon potency. Replacement of the 4-chloro moiety on the pyrimidine core with a Me group, and concomitant mono-alkylation of the C-2 amino moiety resulted in the identification of several inhibitors with desirable characteristics. Nucleoside inhibitor II (R = CF₃, R¹ = Et, R² = H; R = cyclopropyl, R¹ = OEt, R² = Me), from the mono-substituted pyridofuran and inhibitor 50 from the disubstituted series displayed excellent potency, selectivity (GAPDH/MTS CC₅₀) and PK parameters in all species studied, while the selectivity in the thymidine incorporation assay (DNA·CC₅₀) was low.

Bioorganic & Medicinal Chemistry Letters published new progress about 56-05-3. 56-05-3 belongs to pyrimidines, auxiliary class Pyrimidine,Chloride,Amine,API, name is 2-Amino-4,6-dichloropyrimidine, and the molecular formula is C4H3Cl2N3, Related Products of pyrimidines.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Rayavarapu, Suresh published the artcileA modular approach towards functionalized highly stable self-complementary quadruple hydrogen bonded systems, Product Details of C4H3Cl2N3, the publication is Organic & Biomolecular Chemistry (2017), 15(47), 10087-10094, database is CAplus and MEDLINE.

Self-complementary quadruple hydrogen bonded systems have shown potential as key building blocks for developing various supramol. polymers. Opportunities for the introduction of multiple functionalities would further augment, in principle, their application potential. Herein, we report a novel modular approach to simultaneously introduce two closely aligned side chains into AADD-type self-complementary quadruple hydrogen-bonding systems. Dithiane-tethered ureidopyrimidinone has been used as a reactive intermediate to efficiently attach closely aligned side chains by simply reacting with amines to form highly stable mol. duplexes. These duplexes featuring AADD-type arrays of hydrogen bonding codes are highly stable in non-polar solvents (K_dim > 1.9 x 10⁷ M^-1 in CDCl₃) as well as in polar solvents (K_dim > 10⁵ in 10% DMSO-d₆/CDCl₃). Another notable feature of these self-assembling systems is their insensitivity to prototropy-related issues owing to their prototropic degeneracy, which will enhance their application potential in supramol. chem.

Organic & Biomolecular Chemistry published new progress about 56-05-3. 56-05-3 belongs to pyrimidines, auxiliary class Pyrimidine,Chloride,Amine,API, name is 2-Amino-4,6-dichloropyrimidine, and the molecular formula is C4H3Cl2N3, Product Details of C4H3Cl2N3.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Patel, Navin B. published the artcileSynthesis of newer 5-benzylidene-2,4-thiazolidinediones as potential antimicrobials, Name: 2-Amino-4,6-dichloropyrimidine, the publication is Indian Journal of Research in Pharmacy and Biotechnology (2014), 2(1), 993-1001, 9 pp., database is CAplus.

A series of 5-benzylidene-2,4-thiazolidinediones I (R = 5-methylthiazol-2-ylamino, 6-fluorobenzothiazol-2-ylamino, 6-nitrobenzothiazol-2-ylamino, etc.) were synthesized and evaluated for antimycobacterial and antimicrobial activity. In vitro antimycobacterial activity was carried out against (M. tuberculosis) H₃₇Rv strain using Lowenstein-Jensen medium and antimicrobial activity against two Gram pos. bacteria (S. aureus, S. pyogenes), two Gram neg. bacteria (E. coli, P. aeruginosa) and three fungal species (C. albicans, A. niger, A. clavatus) using the broth microdilution method. The compounds I (R = 5-methylthiazol-2-amino, 6-fluorobenzothiazol-2-ylamino, 4-nitrobenzothiazol-2-ylamino, 5-nitrobenzothiazol-2-ylamino, 6-methylbenzothiazol-2-ylamino, 4,6-dimethoxypyrimidin-2-ylamino) exhibited promising antimicrobial activity, whereas compounds I (R = 6-methylbenzothiazol-2-ylamino) showed very good antimycobacterial activity.

Indian Journal of Research in Pharmacy and Biotechnology published new progress about 56-05-3. 56-05-3 belongs to pyrimidines, auxiliary class Pyrimidine,Chloride,Amine,API, name is 2-Amino-4,6-dichloropyrimidine, and the molecular formula is C4H3Cl2N3, Name: 2-Amino-4,6-dichloropyrimidine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia