Category: 56-06-4

Synthetic Route of 56-06-4 ,Some common heterocyclic compound, 56-06-4, molecular formula is C4H6N4O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Synthesis of Compound (37)Intermediate AA (0.5g, 3.96 mmol) was added to a solution of NaOAc (0.647g, 4.76 mmol, 1.2 eq.) in H20 (15 mL). The reaction was heated to 60 C for ~15 minutes, and a solution of 50% aqueous ClCH2CHO (0.5 mL) was then added. The reaction stirred for 2 hours at 60 C. The reaction mixture was filtered to remove undissolved material, and the filtrate stored at 0 C overnight. The resulting precipitated solid was collected by filtration, washed with cold H20, and dried to obtain Compound (37) (120mg, 20%) as a pink solid. Rf = 0.7 (30%MeOH/CHCl3/0.2 mL of aqueous NH3). 1H-NMR (400MHz, DMSO-_¾ delta 10.95 (br. s, exchanged with D20, 1H), 10.20 (s, exchanged with D20, 1H), 6.60 (dd, J = 3.2, 2.0Hz, 1H), 6.18 (dd, J = 3.2, 2.0Hz, 1H), 6.03 (br. s, exchanged with D20, 2H). Mass (m/z): 150.8 (M++l). LCMS: (Column: Zodiacsil 120-5-C-18-Aq (4.6 * 50 mm), Mobile phase: A: 0.01M HCOONH4 (Aq); B: MeOH, T/%B: 0/5, 10/90, 10.1/5, Flow: 1.0 mL/min, Diluent: MeOH), Rt=2.599 min, 99.16 (214 nm), 99.10 (254 nm).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 56-06-4, 2,6-Diaminopyrimidin-4(1H)-one, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; HERCULES TECHNOLOGY MANAGEMENT CO V, INC.; BLAGG, Julian; WO2011/35009; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 56-06-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 56-06-4, name is 2,6-Diaminopyrimidin-4(1H)-one. This compound has unique chemical properties. The synthetic route is as follows.

174 mg of sodium hydride (60% in mineral oil, 4.36 mmol) are added in portions under an argon atmosphere to a vigorously stirred solution of 500 mg (3.96 mmol) of 2,6-diaminopyrimidin-4-ol in 10 ml of DMF. After 30 min, 700 mul (5.15 mmol) of ethyl trifluoromethanesulfonate are added dropwise, and the solution is stirred for a further 20 min. Methanol (1 ml) is then added to the reaction mixture, which is directly purified by preparative HPLC. Combining the product fractions and removing the solvent result in 370 mg (64% of theory) of the title compound as a white solid. LC-MS (method 5): Rt=2.24 min; MS (ESIpos): m/z=155 [M+H]+ 1H-NMR (400 MHz, DMSO-d6): delta=1.21 (t, 3H), 4.12 (q, 2H), 5.00 (s, 1H), 5.87 (s, 2H), 6.01 (s, 2H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 56-06-4, 2,6-Diaminopyrimidin-4(1H)-one.

Reference:
Patent; BAYER HEALTHCARE AG; US2010/35902; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 56-06-4, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 56-06-4, Name is 2,6-Diaminopyrimidin-4(1H)-one, SMILES is O=C1N=C(N)NC(N)=C1, belongs to pyrimidines compound. In a article, author is Nguyen, Stephanie, introduce new discover of the category.

Nucleoside selectivity of Aspergillus fumigatus nucleoside-diphosphate kinase

Aspergillus fumigatus infections are rising at a disconcerting rate in tandem with antifungal resistance rates. Efforts to develop novel antifungals have been hindered by the limited knowledge of fundamental biological and structural mechanisms of A. fumigatus propagation. Biosynthesis of NTPs, the building blocks of DNA and RNA, is catalysed by NDK. An essential enzyme in A. fumigatus, NDK poses as an attractive target for novel antifungals. NDK exhibits broad substrate specificity across species, using both purines and pyrimidines, but the selectivity of such nucleosides in A. fumigatus NDK is unknown, impeding structure-guided inhibitor design. Structures of NDK in unbound- and NDP-bound states were solved, and NDK activity was assessed in the presence of various NTP substrates. We present the first instance of a unique substrate binding mode adopted by CDP and TDP specific to A. fumigatus NDK that illuminates the structural determinants of selectivity. Analysis of the oligomeric state reveals that A. fumigatus NDK adopts a hexameric assembly in both unbound- and NDP-bound states, contrary to previous reports suggesting it is tetrameric. Kinetic analysis revealed that ATP exhibited the greatest turnover rate (321 +/- 33.0 s(-1)), specificity constant (626 +/- 110.0 mm(-1)center dot s(-1)) and binding free energy change (-37.0 +/- 3.5 kcal center dot mol(-1)). Comparatively, cytidine nucleosides displayed the slowest turnover rate (53.1 +/- 3.7 s(-1)) and lowest specificity constant (40.2 +/- 4.4 mm(-1)center dot s(-1)). We conclude that NDK exhibits nucleoside selectivity whereby adenine nucleosides are used preferentially compared to cytidine nucleosides, and these insights can be exploited to guide drug design. Enzymes Nucleoside-diphosphate kinase (). Database Structural data are available in the PDB database under the accession numbers: Unbound-NDK (), ADP-NDK (), GDP-NDK (), IDP-NDK (), UDP-NDK (), CDP-NDK (), TDP-NDK ().

Application of 56-06-4, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 56-06-4 is helpful to your research.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 56-06-4, Name is 2,6-Diaminopyrimidin-4(1H)-one, molecular formula is , belongs to pyrimidines compound. In a document, author is Song Juan, Recommanded Product: 56-06-4.

Synthesis, Crystal Structure and Biological Activity of Ethyl 5-(4-Fluorophenyl)-7-(trifluoromethyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylate

The title compound, C16H11F4N3O2, was synthesized and structurally characterized by elemental analysis, IR, MS, H-1-NMR and single-crystal X-ray diffraction. This compound has a pyrazolo[1,5-a]pyrimidine skeleton, and it crystallizes in monoclinic system, space group P2(1)/c with a = 20.8547(12), b = 20.5558(10), c = 7.1575(4) angstrom, beta = 96.610(5)degrees, V = 3047.9(3) angstrom(3), Z = 4, D-c = 1.540 g.cm(-3), F(000) = 1440, mu(MoK alpha) = 0.14 mm(-1), R = 0.0546 and wR = 0.1276 for 5370 reflections with I > 2 sigma(I). In addition, biological activity determination results indicated that the title compound exhibited poor inhibitory activity on MKN45 and H460 cancer cell lines.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 56-06-4, in my other articles. Recommanded Product: 56-06-4.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Application of 56-06-4, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 56-06-4, Name is 2,6-Diaminopyrimidin-4(1H)-one, SMILES is O=C1N=C(N)NC(N)=C1, belongs to pyrimidines compound. In a article, author is Portalone, Gustavo, introduce new discover of the category.

5-Fluorocytosine/Isocytosine Monohydrate. The First Example of Isomorphic and Isostructural Co-Crystal of Pyrimidine Nucleobases

To date, despite the crucial role played by cytosine, uracil, and thymine in the DNA/RNA replication process, no examples showing isomorphic and isostructural behavior among binary co-crystals of natural or modified pyrimidine nucleobases have been so far reported in the literature. In view of the relevance of biochemical and pharmaceutical compounds such as pyrimidine nucleobases and their 5-fluoroderivatives, co-crystals of the molecular complex formed by 5-fluorocytosine and isocytosine monohydrate, C4H4FN3O center dot C4H5N3O center dot H2O, have been synthesized by a reaction between 5-fluorocytosine and isocytosine. They represent the first example of isomorphic and isostructural binary co-crystals of pyrimidine nucleobases, as X-ray diffraction analysis shows structural similarities in the solid-state organization of molecules with that of the (1:1) 5-fluorocytosine/5-fluoroisocytosine monohydrate molecular complex, which differs solely in the H/F substitution at the C5 position of isocytosine. Molecules of 5-fluorocytosine and isocytosine are present in the crystal as 1H and 3H-ketoamino tautomers, respectively. They form almost coplanar WC base pairs through nucleobase-to-nucleobase DAA/ADD hydrogen bonding interactions, demonstrating that complementary binding enables the crystallization of specific tautomers. Additional peripheral hydrogen bonds involving all available H atom donor and acceptor sites of the water molecule give a three-dimensional polymeric structure. In the absence of HMIDLINE HORIZONTAL ELLIPSISF hydrogen-bonding interactions, the robustness of the supramolecular architectures based on three-point recognition synthons is responsible for the existence of isostructurality between the two molecular complexes.

Application of 56-06-4, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 56-06-4 is helpful to your research.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 56-06-4, Name is 2,6-Diaminopyrimidin-4(1H)-one, molecular formula is C4H6N4O, belongs to pyrimidines compound, is a common compound. In a patnet, author is Lyapustin, Daniil N., once mentioned the new application about 56-06-4, Formula: C4H6N4O.

6-Nitro-4,7-dihydroazolo [1,5-a]pyrimidines: an alternative mechanism of formation and studies of alkylation

The mechanism of a multicomponent reaction between aminoazoles, 1-morpholino-2-nitroalkenes, and benzaldehyde was studied in acidic medium. Performing the reaction in acetic acid led to the formation of 6-nitro-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]-pyrimidines, which subsequently underwent a rearrangement. Reaction conditions were proposed for a multicomponent synthesis with trioxane, and the alkylation reactions of 4,7-dihydroazolo[1,5-a]pyrimidine nitro derivatives were optimized.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 56-06-4. The above is the message from the blog manager. Formula: C4H6N4O.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 56-06-4, Name is 2,6-Diaminopyrimidin-4(1H)-one, molecular formula is C4H6N4O. In an article, author is Shi, Jia,once mentioned of 56-06-4, HPLC of Formula: C4H6N4O.

Insight into Monascus pigments production promoted by glycerol based on physiological and transcriptome analyses

Monascus pigments (MPs) are widely used natural colorants in Asian countries. MPs production can be significantly enhanced by glycerol, though its mechanism remains unknown. In this study, behind glycerol-enhanced MPs production was investigated through physiological and transcriptome analyses. Monascus pilosus MS-1 was cultured in synthetic media with 0, 40 or 160 g/L glycerol which were marked as CK, G40, and G160, respectively. Monascus growth and MPs production were significantly enhanced by glycerol. Differentially expressed genes (DEGs) found in the CK vs G40 group involved in oxidation-reduction and glycolytic processes were upregulated, while that of RNA-DNA hybrid ribonuclease activity and RNA-dependent DNA biosynthetic process were downregulated. The downregulated genes related to G160 were significantly enriched in GO terms of nucleolus, 90S preribosome, and small and large subunit precursors. KEGG analysis indicated that most of the upregulated genes belonging to the CK vs G40 and CK vs G160 groups were related to glycolysis and carbon metabolism. However, DEGs belonging to groups related to G160 involved in ribosome biogenesis in eukaryotes and pyrimidine metabolism were downregulated. Therefore, glycerol promotion of MPs production may be attributed to more substrates for MPs biosynthesis generated from glycolysis and carbon metabolism.

Interested yet? Keep reading other articles of 56-06-4, you can contact me at any time and look forward to more communication. HPLC of Formula: C4H6N4O.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Application of 56-06-4, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 56-06-4, Name is 2,6-Diaminopyrimidin-4(1H)-one, SMILES is O=C1N=C(N)NC(N)=C1, belongs to pyrimidines compound. In a article, author is Ali, T. E., introduce new discover of the category.

Regioselective Synthesis of Novel Functionalized Pyrano[2′,3′:4,5]pyrimido[1,6-b][1,2,4,5]triazaphosphepines

The reactions of 6-acetyl- 3-amino-4- imino-7-methyl-5-phenyl-3,5-dihydro-4H-pyrano[2,3-d]pyrimi dine with triethyl phosphite and some electrophilic reagents, namely 1,2-dibromoethane, oxalyl chloride, chloroacetyl chloride, and ethyl chloroacetate, were studied. These one-pot three-component reactions regioselectively afforded four new 11-acetyl-2-ethoxy-10-methyl-12- phenylpyrano[2′,3′:4,5]pyrimido[1,6-b][1,2,4,5.5]triazaphosphepin-2-ones in 69-73% yields.

Application of 56-06-4, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 56-06-4 is helpful to your research.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Synthetic Route of 56-06-4, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 56-06-4, Name is 2,6-Diaminopyrimidin-4(1H)-one, SMILES is O=C1N=C(N)NC(N)=C1, belongs to pyrimidines compound. In a article, author is Mary, Y. Sheena, introduce new discover of the category.

DFT, SERS-concentration and solvent dependent and docking studies of a bioactive benzenesulfonamide derivative

Spectroscopic analysis, DFT studies and surface enhanced Raman scattering (SERS) of antimicrobial bioac- tive 4-[(5-tert-butyl)2-hydroxybenzylidene]amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide (THPB) have been studied on different silver sols. Intensity and hence enhancement variations are observed for Raman and SERS bands. Observed changes in the ring modes may be due to surface pi-electron interactions and presence of this indicated that molecule is inclined with respect to the metal surface. Changes in orientation are seen in SERS spectra depending on concentration. The molecular docking results show that binding affinity and interactions with the receptors may be supporting evidence for further studies in design further THPB pharmaceutical applications. Reactivity properties are obtained from DFT analysis. (C) 2020 Elsevier B.V. All rights reserved.

Synthetic Route of 56-06-4, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 56-06-4 is helpful to your research.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Chemistry, like all the natural sciences, Computed Properties of C4H6N4O, begins with the direct observation of nature¡ª in this case, of matter.56-06-4, Name is 2,6-Diaminopyrimidin-4(1H)-one, SMILES is O=C1N=C(N)NC(N)=C1, belongs to pyrimidines compound. In a document, author is Adigun, Rasheed A., introduce the new discover.

Substitutional effects on the reactivity and thermal stability of dihydropyrimidinones

One of the advantages of dihydropyrimidinones (DHPMs) is the molecular diversity that could be achieved through their synthesis from a three-component reaction by varying the starting reaction materials. Differences in substituted functional groups could lead to varying reactivities and thermal stability amongst the analogues. In this study, two different classes of DHPMs were synthesized and the effects of the various substituents on the DHPM ring were investigated. The compounds were structurally characterized using single-crystal X-ray diffractometry, H-1, C-13, COSY, HSQC and HMBC NMR techniques, FT-IR and High Resolution Mass Spectrometry (HRMS). N1 methylation of the DHPM was found to increase the thermal stability of the series of DHPMs investigated, which is an added advantage in thermal reactions. The nature of the alkyl substituent of the ester group at position 5 of the DHPM was also found to affect the ease of the nucleophilic substitution reaction during the functionalization of the DHPMs. A complementary DFT study aided in understanding the above results as well as to compare the general stability of the range of compounds. (C) 2020 Elsevier B.V. All rights reserved.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 56-06-4. Computed Properties of C4H6N4O.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia