Category: 56-09-7

Adding a certain compound to certain chemical reactions, such as: 56-09-7, 2-Amino-6-hydroxypyrimidin-4(3H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 56-09-7, blongs to pyrimidines compound. 56-09-7

General procedure: Typically, 2-aminopyrimidine-4,6-diol (1a, 0.5 mmol, 1.0 equiv)/2-methylpyrimidine-4,6-diol (1b, 0.5 mmol, 1.0 equiv), nitroolefins (2, 0.5 mmol, 1.0 equiv), as well as water (2.5 mL) were introduced into a 10 mL reaction vial. Then, the reaction vial was closed and stirred for given time at 90 C. Upon completion, the reaction mixture was cooled to room temperature and diluted with cold water (30 mL). The solid product was collected by filtration and was purified by recrystallization from hot 95% EtOH to afford the goal product 5-arylfuro[2,3-d]pyrimidin-4-ol (3) as off-white to yellow solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,56-09-7, its application will become more common.

Reference:
Article; Li, Chunmei; Zhang, Furen; Tetrahedron Letters; vol. 58; 16; (2017); p. 1572 – 1575;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

56-09-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 56-09-7, name is 2-Amino-6-hydroxypyrimidin-4(3H)-one. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Palladium catalysts 31a-c, 103, 104 and 105 were synthesized following reported procedures.20,24 2-amino-4,6-dihydroxypyrimidine or pyrimidine-4,6-diol based ligands (95 and 97) (20.0 mumol) weredissolved in an aqueous solution of YOH (0.4 mL, 0.1m) in an ultrasonic bath for 2 minutes. Thepalladium source (10.0 mumol) was added and the mixture was magnetically stirred at 65 C for 30 minutes, deionized water (0.6 mL) was then added to afford a 10.0 mM catalyst solutions of 31a-c and,103-105. The 40.0 mM catalyst solution was achieved with a 0.2 M solution of YOH.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 56-09-7, 2-Amino-6-hydroxypyrimidin-4(3H)-one.

Reference:
Article; Tessier, Romain; Ceballos, Javier; Guidotti, Nora; Simonet-Davin, Raphael; Fierz, Beat; Waser, Jerome; Chem; vol. 5; 8; (2019); p. 2243 – 2263;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 56-09-7, name is 2-Amino-6-hydroxypyrimidin-4(3H)-one, molecular formula is C4H5N3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 56-09-7

To an ice-cold stirred solution of POCl3 (9.72g, 63.38 mmol) was added dry DMF dropwise over a period of 5 minutes. The ice-bath was removed, andIntermediate EE (1.0g, 7.87 mmol) was added in small portions under stirring and N2 atmosphere. After the exothermic reaction ceased, the reaction mixture was brought up to 100C and stirred for 1.5 hours. The solution was cooled to room temperature, reduced to half the volume under reduced pressure, poured into ice- ater (15 mL), and warmed to 50C for 2 hours. A pale yellow precipitate then separated out, and the precipitate was filtered, washed with water (~10 mL) and acetone (-10 mL), and then dried. The Intermediate FF (580 mg, 38.4%) was obtained as pale yellow solid. 1H NMR (300 MHz, DMSO-i?) delta 10.05 (s, CHO), 8.49 (s, 2H, D20 exchangeable).

The chemical industry reduces the impact on the environment during synthesis 56-09-7, I believe this compound will play a more active role in future production and life.

Reference:
Patent; HERCULES TECHNOLOGY MANAGEMENT CO V, INC.; BLAGG, Julian; WO2011/35009; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

56-09-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 56-09-7, name is 2-Amino-6-hydroxypyrimidin-4(3H)-one, molecular formula is C4H5N3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of 2-amino-pyrimidine-4,6-diol 28.00g (0.22mol), thionyl chloride 80ml (1.1mol) into 250ml 4-neck flask, heated to reflux for 4h.After completion of the reaction, the heat is turned off, cooled to room temperature, the reaction was quenched by slowly poured into ice water.In this case large amount of solid precipitated, filtered off with suction, the filter cake was rinsed with potable water to pH 7.The wet cake at 60 deg.] C blast drying to constant weight, to give a pale yellow product 33.45g, this step a yield of 92.7%, HPLC purity was 99.1%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 56-09-7, 2-Amino-6-hydroxypyrimidin-4(3H)-one, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Weihai Disu Pharmaceutical Co., Ltd.; Disha Pharmaceutical Group Co., Ltd.; Liu Chao; Ge Zhixin; Li Tingyi; Miao Huaming; Cai Yahui; (13 pag.)CN109456329; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia