Category: 5604-46-6

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5604-46-6, name is 2-Amino-4,6-dichloropyrimidine-5-carbaldehyde, molecular formula is C5H3Cl2N3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Computed Properties of C5H3Cl2N3O

Example 108 Step A: (108A) A suspension of 2-amino-4,6-dichloro-pyrimidine-5-carboxaldehyde (300 mg, 1.56 mmol) and tert-butylhydrazine hydrochloride (390 mg, 3.13 mmol) in THF (15 ML) and triethyl amine (0.44 mL, 3.13 mmol) was stirred at rt for 5 min and then heated to 64C for 40 min. The reaction mixture was concentrated and diluted with water at 0C. The solid was filtered, washed with water and dried in vacuo over P205 to obtain the title compound 108A (240 mg, 68% yield) as a yellow solid. HPLC retention time: 2.11 min ; LC/MS : 226.10 (M+H) +.

With the rapid development of chemical substances, we look forward to future research findings about 5604-46-6.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2003/99820; (2003); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5604-46-6, name is 2-Amino-4,6-dichloropyrimidine-5-carbaldehyde, molecular formula is C5H3Cl2N3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 5604-46-6

1 (324 mg, 1.7 mmol) was dissolved in a mixed solution of 7 mL of tetrahydrofuran and water (3:1), warmed to 50 C, and hydrazine hydrate (170 mg, 3.3 mmol) was dissolved in 1.7 mL of water, slowly dripping Adding to the reaction solution, stirring for 40 min, the reaction solution was poured into 8 mL of ice water and stirred for 15 min, allowed to stand for 20 min, then filtered, and the filter cake was washed with acetone to obtain 0.23 g of pale yellow solid, yield 78.4%

With the rapid development of chemical substances, we look forward to future research findings about 5604-46-6.

Reference:
Patent; China Pharmaceutical University; Lai Yisheng; Di Rongrong; Ma Jun; Wang Lei; Liu Yu; Gu Mengyue; Kang Nannan; Li Yuezhen; (15 pag.)CN108371662; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5604-46-6, name is 2-Amino-4,6-dichloropyrimidine-5-carbaldehyde, molecular formula is C5H3Cl2N3O, molecular weight is 192.0028, as common compound, the synthetic route is as follows.HPLC of Formula: C5H3Cl2N3O

A solution of lambda/-methylpiperazine (0.624ml), 2-amino-4,6-dichloro-5- formylpyrimidine (1.0Og) and DIPEA (0.936ml) in NMP (120ml) is stirred at room temperature for 18 hours. After addition of MTBE (400ml) the mixture is washed with a saturated solution of NaHCtheta3 (2 x 120ml) and brine (1 x 50ml), dried (MgStheta4) and concentrated to give the title compound as a colourless oil (509mg, 38%). LCMS 255/257 [M+H]+ (pH5.8), RT 1.67 mins. 1H NMR 300 MHz (d6-DMSO) (delta ppm): 10.07 (1H, s), 5.32 (2H1 bs), 3.66 – 3.58 (4H, m), 2.57 – 2.46 (4H, m).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,5604-46-6, 2-Amino-4,6-dichloropyrimidine-5-carbaldehyde, and friends who are interested can also refer to it.

Reference:
Patent; UCB PHARMA, S.A.; WO2008/74445; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 5604-46-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5604-46-6, name is 2-Amino-4,6-dichloropyrimidine-5-carbaldehyde. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of tert-butyl (3S)-3-ethylpiperazine-l -carboxylate (0.5 g, 2.3 mmol) and 2-amino-4,6-dichloropyrimidine-5-carbaldehyde (0.45 g) in 1,4-dioxane (8.0 mL) was added DIPEA (1.2 mL, 7.0 mmol). The reaction mixture was heated at 120C overnight in a sealed Wheaton vial, then cooled and stirred at room temperature over the weekend. The solvent was removed in vacuo, and the residue was partitioned between water and DCM. The organic layers were phase separated and concentrated in vacuo to give the title compound (0.85 g, 99%) as a yellow glass. LCMS (ES+) [M+H]+ 370, RT 1.81 minutes (method 2).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5604-46-6, 2-Amino-4,6-dichloropyrimidine-5-carbaldehyde.

Reference:
Patent; UCB PHARMA S.A.; KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D; FORD, Daniel James; FRANKLIN, Richard Jeremy; GHAWALKAR, Anant Ramrao; HORSLEY, Helen Tracey; HUANG, Qiuya; REUBERSON, James Thomas; VANDERHOYDONCK, Bart; WO2014/96423; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 5604-46-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5604-46-6, name is 2-Amino-4,6-dichloropyrimidine-5-carbaldehyde. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of tert-butyl (3S)-3-ethylpiperazine-l -carboxylate (0.5 g, 2.3 mmol) and 2-amino-4,6-dichloropyrimidine-5-carbaldehyde (0.45 g) in 1,4-dioxane (8.0 mL) was added DIPEA (1.2 mL, 7.0 mmol). The reaction mixture was heated at 120C overnight in a sealed Wheaton vial, then cooled and stirred at room temperature over the weekend. The solvent was removed in vacuo, and the residue was partitioned between water and DCM. The organic layers were phase separated and concentrated in vacuo to give the title compound (0.85 g, 99%) as a yellow glass. LCMS (ES+) [M+H]+ 370, RT 1.81 minutes (method 2).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5604-46-6, 2-Amino-4,6-dichloropyrimidine-5-carbaldehyde.

Reference:
Patent; UCB PHARMA S.A.; KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D; FORD, Daniel James; FRANKLIN, Richard Jeremy; GHAWALKAR, Anant Ramrao; HORSLEY, Helen Tracey; HUANG, Qiuya; REUBERSON, James Thomas; VANDERHOYDONCK, Bart; WO2014/96423; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5604-46-6, name is 2-Amino-4,6-dichloropyrimidine-5-carbaldehyde, the common compound, a new synthetic route is introduced below. Recommanded Product: 5604-46-6

2.1 Preparation of 2-Amino-4-chloro-6-dibenzylamino-5-pyrimidine Carbaldehyde 2-Amino-4,6-dichloro-5-pyrimidine carbaldehyde (0.15 g; 0.78 mmol) prepared as in Scheme 1 was stirred in dry dichloromethane (3 ml) at 0 C. Dibenzylamine (1 eq; 0.78 mmol; 0.154 g) and triethylamine (1 eq; 0.78 mmol; 0.078 g) were added dropwise. The reaction was allowed to reach r.t, and stirred overnight by which time a clear solution had been obtained. Further dichloromethane (50 ml) was added and the solution washed with saturated sodium chloride solution and water. _:The organic layer was dried and evaporated leaving a yellow solid (0.253 g; 0.72 mmol; 92.3%). M.p. 138-142 C.

The synthetic route of 5604-46-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Cancer Research Campaign Technology Limited; US6677345; (2004); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 5604-46-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5604-46-6, name is 2-Amino-4,6-dichloropyrimidine-5-carbaldehyde, molecular formula is C5H3Cl2N3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

4-(4-methoxyphenyl)aniline under nitrogen protection(11.4 g, 57.3 mmol, which can be synthesized by reference to RazlerTM et al. Journal of Organic Chemistry; vol. 74; nb. 3; (2009); p. 1381-1384)The anhydrous tetrahydrofuran (120 mL) solution was cooled with an ice water bath.Sodium hydrogen (60% mineral oil powder, 4.6 g 114.6 mmol) was carefully added in portions.After the addition was completed, the reaction was further stirred for about half an hour, and 2-amino-4,6-dichloropyrimidine-5-carbaldehyde (10.0 g, 52.1 mmol) was further added.The ice water bath was removed, and the reaction was allowed to react at room temperature for about 8-10 hours, and was monitored by TLC (petrole ether: ethyl acetate = 2:1) until the reaction was completed.The reaction was quenched by dropwise addition of water (20 mL). Additional ethyl acetate (200 mL) was added. The resulting mixed solution was washed with saturated brine (100 mL*3).The organic layer was dried over anhydrous sodium sulfate, filtered, evaporated, evaporated, evaporated, evaporated. 2-amino-4-(4-(4-methoxyphenyl)anilino)-6-chloropyrimidine-5-carboxaldehyde in a yield of 82.7%.

According to the analysis of related databases, 5604-46-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Chengdu University of Technology; Zhou Lihong; (40 pag.)CN105111151; (2018); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 5604-46-6 ,Some common heterocyclic compound, 5604-46-6, molecular formula is C5H3Cl2N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

N-(3-(4-aminomethylphenyl)phenyl)urea (10.0 g, 41.4 mmol)In ethanol (100mL) solution,Triethylamine (21.2g, 0.21mol) was addedAnd 2-amino-4,6-dichloropyrimidine-5-carbaldehyde (8.0 g, 41.4 mmol).The reaction solution was heated to reflux with an oil bath and was reacted for about 6-7 hrs, and was monitored by TLC (dichloromethane:methanol = 10:1) until the reaction was completed.The solvent was evaporated under reduced pressure, water (200 mL) was evaporated, and then filtered and filtered, and the filter cake was recrystallized from ethanol and dried in vacuo to give 14.4 g of pale yellow solid as 2-amino-4-(4-(3-ureidobenzene) Base) benzylamino)-6-chloropyrimidine-5-carboxaldehyde in a yield of 88.4%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 5604-46-6, 2-Amino-4,6-dichloropyrimidine-5-carbaldehyde, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Chengdu University of Technology; Zhou Lihong; (40 pag.)CN105111151; (2018); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 5604-46-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5604-46-6, name is 2-Amino-4,6-dichloropyrimidine-5-carbaldehyde. A new synthetic method of this compound is introduced below.

The compound of formula () (2.4g, 12.5mmol) and 37.5mL THF was added 12.5mL H 2 O mixed solution Were heated to 50 C, was added hydrazine hydrate (1.5g, 25.2mmol), 50 C After stirring for 5min, stirred at room temperature for 20min, was added 100mL of ice water stirring 15min, after unscrew the THF was filtered and dried under vacuum to give a yellow solid 2.06 g, yield 97.6%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,5604-46-6, 2-Amino-4,6-dichloropyrimidine-5-carbaldehyde, and friends who are interested can also refer to it.

Reference:
Patent; Shanghai Jiao Tong University; Shen, YuMei; Wei, XiaoFei; Gong, Bing; Hu, Yu; Jiang, Yu; Zhao, XioaDong; Shao, Zhifeng; Li, Xiaowei; Wu, XinYan; Tang, Daonian; Liu, Yazhi; (28 pag.)CN103804447; (2016); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 5604-46-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5604-46-6, name is 2-Amino-4,6-dichloropyrimidine-5-carbaldehyde. This compound has unique chemical properties. The synthetic route is as follows.

Example 1; 2-Amino-4-[methoxyimino-(4-methyl-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-methyl]-thieno[2,3-d]pyrimidine-6-carboxylic acid ethylamide; Step 1; 2-Amino-4-chloro-thieno[2,3-d]pyrimidine-6-carboxylic acid ethyl ester; To a stirred mixture of 2-amino-4,6-dichloro-5-formyl-pyrimidine (available from Bionet Research Intermediates, UK) (5.Og 1 eq.) and potassium carbonate (9.0 g; 2.5 equiv.) in acetonitrile (160ml) at ambient temperature was added ethyl-2-mercaptoacetate (2.86 ml; 1.0 equiv.). The resulting mixture was stirred at reflux for three hours. After cooling, the solvents were removed in vacuo and the residue partitioned between ethyl acetate and water, the phases separated and the organic phase washed with saturated aqueous sodium chloride solution. Phases were separated and the organic phase was dried over Na2SO4 then filtered and filtrate solvents removed in vacuo. The crude product was purified by column chromatography on silica gel, eluting with ethyl acetate and hexanes, to afford 2-Amino-4-chloro- thieno[2,3-d]pyrimidine-6-carboxylic acid ethyl ester as a yellow powder (60%).LC-MS: RT = 2.371 minutes, m/z = 258.0 [M+H]+ (Total run time = 3.5 minutes)

According to the analysis of related databases, 5604-46-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; VERNALIS R & D LTD; CANCER RESEARCH TECHNOLOGY LTD; THE INSTITUTE OF CANCER RESEARCH; WO2006/79789; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia