Category: 56621-90-0

Adding a certain compound to certain chemical reactions, such as: 56621-90-0, 5-Amino-2-chloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 5-Amino-2-chloropyrimidine, blongs to pyrimidines compound. Quality Control of 5-Amino-2-chloropyrimidine

2-Chloropyrimidin-5-amine (500 mg, 3.86 mmol) was added to a suspension of an aqueous Na2CO3 solution (2.0 M, 3.9 ml_, 7.72 mmol), (0525) Pd(dppf)CI2.CH2Cl2 (252 mg, 0.308 mmol ) and 4-fluorophenyl boronic acid (801 mg, 5.78 mmol ) in 1 ,4- dioxane (15 ml_). The reaction mixture was refluxed for 5 h and allowed to reach rt, poured into water (20 ml_) and extracted with EtOAc. The combined organic layers were dried over anh. Na2SO4, filtered and concentrated. The crude product thus obtained was purified by flash chromatography on silica gel, gradient acetone/hexane (40:0) to give the title compound as yellow oil (765 mg, 94% yield). (0526) 1H-NMR (CDCIs, 250 MHz, delta): 8.27 (m, 4H, ArH); 7.1 1 (m, 2H, ArH); 3.77 (bs 2H, NH2). (0527) HPLC-MS (Method C): Ret, 7.84 min; ESI+-MS m/z, 190.2 (M+1 ).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,56621-90-0, 5-Amino-2-chloropyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; LABORATORIOS DEL DR. ESTEVE, S.A.; TORRENS-JOVER, Antoni; JAGEROVIC, Nadine; ALMANSA-ROSALES, Carmen; (157 pag.)WO2017/178515; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 56621-90-0, 5-Amino-2-chloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 56621-90-0, blongs to pyrimidines compound. SDS of cas: 56621-90-0

A mixture of the pyrimidine from step 4 (100 mg, 0.77 mmol), indole boronic acid from step 3 (290 mg, 0.77 mmol), Pd(dppf)Cl2 (56 mg, 0.077 mmol), Na2CO3 (244 mg, 2.3 mmol), THF (20 mL) and H2O (2 mL) was refluxed under N2 overnight. The mixture was poured into water and extracted with CH2Cl2. The organic phase was combined, dried over Na2SO4 and filtered. The filtrate was purified by prep TLC (CH2Cl2/MeOH=20/1) to afford the product. MS (ESI) m/e (M+H+): 426.

The synthetic route of 56621-90-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Merck Sharp & Dohme Corp.; Coburn, Craig A.; Ludmerer, Steven W.; Liu, Kun; Wu, Hao; Soll, Richard; Zhong, Bin; Zhu, Jian; (155 pag.)US2019/127365; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.56621-90-0, name is 5-Amino-2-chloropyrimidine, molecular formula is C4H4ClN3, molecular weight is 129.5477, as common compound, the synthetic route is as follows.Quality Control of 5-Amino-2-chloropyrimidine

To a solution of triphosgene (1.38 g, 4.65 mmol) in Ethyl acetate (20 ml) at 0 C. a solution of 2-chloro-5-aminopyrimidine (1 g, 7.75 mmol)/DIPEA (8 ml, 4.65 mmol) in ethyl acetate (40 ml) was slowly added (20 minutes) and the reaction mixture was stirred for 15 minutes at the same temperature. Maintaining the reaction mixture at 0 C., vacuum was applied (10 minutes) for removing the excess of phosgene. A solution of DMAP (0.945 g, 7.75 mmol) in ethyl acetate/dichloromethane 1:1 (8 ml) was added and the reaction mixture was stirred for 5 minutes at the same temperature. A solution of methyl (R)-2-amino-2-methyl-butyrate hydrochloride (2.59 g, 15.5 mmol) in ethyl acetate (30 ml) was slowly added (15 minutes) at 0 C. and the reaction mixture was stirred for 30 minutes at the same temperature. The reaction was quenched with aqueous buffer (pH3) while the pH was allowed to reach 5-6 and two phases were separated. The organic layer was washed with aqueous buffer (pH3) (2×20 ml) and then brine (20 ml), dried (Na2SO4), filtered and evaporated affording the urea intermediate as orange foam. The urea was dissolved in MeOH (20 ml), NaOMe (0.41 g, 7.75 mmol) was added and the reaction mixture was stirred for 15 minutes at r.t. The mixture was quenched with an aqueous saturated solution of ammonium chloride (25 ml) and diluted with ethyl acetate (50 ml). Two phases were separated and the organic layer was washed with brine (2×20 ml), dried (Na2SO4), filtered and evaporated. The residue was triturated with Et2O (10 ml) and the solid collected affording the title compound (1.22 g) as a beige solid. LC/MS: QC-3_MIN: Rt=1.341 min; 255 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,56621-90-0, 5-Amino-2-chloropyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Alvaro, Giuseppe; Marasco, Agostino; US2014/323508; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.56621-90-0, name is 5-Amino-2-chloropyrimidine, molecular formula is C4H4ClN3, molecular weight is 129.5477, as common compound, the synthetic route is as follows.HPLC of Formula: C4H4ClN3

[0092] 5-Amino-2-chloro pyrimidine (1-2) (2.7 g, 20.6 mmol), 2-chloro-5-methoxy benzoyl chloride (4.2 g, 20.6 mmol)and triethylamine (7 mL) are dissolved in dichloromethane (40 mL). The resultant mixture is stirred overnight at roomtemperature. After removing the solvent by evaporation, the residue is poured into ethyl acetate and water for extractionseparation. The combined organic phase is dried through anhydrous sodium sulfate, concentrated under vacuum, andpurified by silica gel column chromatography to give compound (1-3) (5.7 g, 82.6%) as a white solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,56621-90-0, 5-Amino-2-chloropyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Hangzhou Bensheng Pharmaceutical Co., Ltd.; XU, Rongzhen; XIE, Fuwen; LAI, Hongxi; RONG, Frank; EP2615092; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 56621-90-0, Adding some certain compound to certain chemical reactions, such as: 56621-90-0, name is 5-Amino-2-chloropyrimidine,molecular formula is C4H4ClN3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 56621-90-0.

A mixture of 5-Amino-2-chloro-pyrimidine (4.5 g, 34.9 mmol), 3- TRIFUOROMETHYLPHENYLBORONIC acid (9.9 g, 52.3 MMOL), Pd (OAc) 2 (390 MG, 1.74 MMOL), DPPF (963 mg, 1.74 MMOL), 2 M aqueous K2C03 (52 mL), and toluene (100 mL) were heated at 110 C for 16 h. The mixture was diluted with EtOAc (100 mL) and the organic layer washed with H20 (100 mL) and brine (100 mL). Drying (MgS04) and removal of the volatiles in-vacuo gave a dark brown solid. Chromatography of this material on silica gel using a Hexanes/EtOAc gradient (20% EtOAc to 80% EtOAc) gave 3 as a colorless solid (3.5 g, 14.6 MMOL, 41% yield, M/Z + = 240. 1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 56621-90-0, 5-Amino-2-chloropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CYTOKINETICS, INC.; WO2005/5382; (2005); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia