4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Formula: C9H12FN3O4
Cell differentiation effects of 2′-fluoro-1-β-D-arabinofuranosyl pyrimidines in HL-60 cells was written by Kong, Xiang Bin; Andreeff, Michael; Fanucchi, Michael P.; Fox, Jack J.; Watanabe, Kyoichi A.; Vidal, Pedro; Chou, Ting Chao. And the article was included in Leukemia Research in 1987.Formula: C9H12FN3O4 The following contents are mentioned in the article:
A group of 2′-fluoro and 5-substituted arabinosyl pyrimidines and a group of base-substituted pseudoisocytidine analogs were evaluated for their capacity to induce differentiation in the human promyelocytic leukemia cell line, HL-60. These compounds were compared to 1-β-D-arabinofuranosylcytosine nAra-C) by monitoring: (1) inhibition of cell growth; (2) morphol. maturation; (3) nitroblue tetrazolium (NBT) reduction; (4) expression of a myeloid differentiation antigen, Mo1; and (5) inhibition of colony formation. Exposure of logarithmically growing cells for 5 days to Ara-C, 2′-fluoro-Ara-C (FAC), 2′-fluoro-5-methyl-Ara-C (FMAC) and 2′-fluoro-5-ethyl-Ara-C (FEAC) resulted in cell growth inhibition at 50% inhibitory concentrations of 0.007, 0.11, 1.7 and 18 μM and at cytostatic concentrations of 0.1, 0.5, 5.0 and 50 μM, resp. These compounds induced granulocytic and monocytic maturation, reduction of NBT, increased expression of Mo1 antigen and a decrease or loss of both cell proliferation and colony formation in a semisolid medium. There were few, if any, cell differentiation effects for the uracil nucleosides and pseudoisonucleosides tested. Ara-C was the most cytotoxic of the compounds When comparing absolute numbers of differentiated cells, i.e. percent of pos. cells multiplied by the number of viable cells, FAC, FMAC, and FEAC were superior to Ara-C in inducing differentiation of HL-60 cells. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Formula: C9H12FN3O4).
4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Formula: C9H12FN3O4
56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8