Category: 56632-83-8

Nucleosides. 133. Synthesis of 5-alkenyl-1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)cytosines and related pyrimidine nucleosides as potential antiviral agents was written by Perlman, Michael E.; Watanabe, Kyoichi A.; Schinazi, Raymond F.; Fox, Jack J.. And the article was included in Journal of Medicinal Chemistry in 1985.Reference of 56632-83-8 The following contents are mentioned in the article:

The preparation of 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)cytosines with a halovinyl or vinyl substituent at C-5 (I, R = CH:CHBr, CH:CHI, CH:CH2) was accomplished from the corresponding 5-iodo and/or 5-chloromercuri nucleoside analog with use of Li2PdCl4- and Pd(OAc)2-mediated coupling reactions. Thiation of the benzoylated derivative of 2′-fluoro-5-ethyl-ara-U followed by S-methylation and then ammonolysis provided I (R = Et). 5-Ethynyl-2′-fluoro-ara-C and 5-ethynyl-2′-fluoro-ara-U (II; R1 = CCH; Z = NH, O) were obtained from the perisilylated 5-iodo nucleosides by PdII/CuI catalyzed coupling with (trimethylsilyl)acetylene. Most of the new compounds showed activity in vitro against both HSV-1 and HSV-2, as did the known corresponding 5-alkenyluracil nucleosides synthesized earlier. The therapeutic indexes of these compounds are in some cases superior to those of 2′-fluoro-5-methyl-ara-U. Moderate antileukemic activity was observed in vitro for the 5-alkynyl and 5-vinyl compounds The competition of these compounds with thymidine for viral-induced thymidine kinases was also studied. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Reference of 56632-83-8).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Reference of 56632-83-8

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8

Exploring Atypical Fluorine-Hydrogen Bonds and Their Effects on Nucleoside Conformations was written by O’Reilly, Daniel; Stein, Robin S.; Patrascu, Mihai Burai; Jana, Sunit Kumar; Kurian, Jerry; Moitessier, Nicolas; Damha, Masad J.. And the article was included in Chemistry – A European Journal in 2018.Category: pyrimidines The following contents are mentioned in the article:

The ability of fluorine to serve as a hydrogen-bond acceptor has been debated for many years. Short fluorine-hydrogen contacts are thought to play a key role in stabilizing some complex supramol. systems. To directly probe the existence of fluorine-hydrogen bonds, we have performed NMR spectroscopy and computational modeling on a series of C2′-fluorinated nucleosides. Specifically, quantum mechanics/mol. mechanics (QM/MM) anal. and [19F,1H] HMBC NMR experiments provided direct evidence for a C-H…F hydrogen bond in a 2′-F,4′-C-α-alkyL-ribonucleoside analog. This interaction was also supported by QTAIM and NBO analyses, which confirmed a bond critical point for the C-H…F interaction (0.74 kcal mol-1). In contrast, although conformational anal. and NMR experiments of 2′-deoxy-2′-fluoro-arabinonucleosides indicated a close proximity between the 2′-fluorine and the H6/8 protons of the nucleobase, mol. simulations did not provide evidence for a C-H…F hydrogen bond. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Category: pyrimidines).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Category: pyrimidines

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8

Gemcitabine, pyrrologemcitabine, and 2′-fluoro-2′-deoxycytidines: Synthesis, physical properties, and impact of sugar fluorination on silver ion mediated base pairing was written by Guo, Xiurong; Leonard, Peter; Ingale, Sachin A.; Seela, Frank. And the article was included in Chemistry – A European Journal in 2017.SDS of cas: 56632-83-8 The following contents are mentioned in the article:

The stability of silver-mediated “”dC-dC”” base pairs relies not only on the structure of the nucleobase, but is also sensitive to structural modification of the sugar moiety. 2′-Fluorinated 2′-deoxycytidines with fluorine atoms in the arabino (up) and ribo (down) configuration as well as with geminal fluorine substitution (anticancer drug gemcitabine) and the novel fluorescent phenylpyrrolo-gemcitabine (phPyrGem) have been synthesized. All the nucleosides display the recognition face of naturally occurring 2′-deoxycytidine. The nucleosides were converted into phosphoramidites and incorporated into 12-mer oligonucleotides by solid-phase synthesis. The addition of silver ions to DNA duplexes with a fluorine-modified “”dC-dC”” pair near the central position led to significant duplex stabilization. The increase in stability was higher for duplexes with fluorinated sugar residues than for those with an unchanged 2′-deoxyribose moiety. Similar observations were made for “”dC-dT”” pairs and to a minor extent for “”dC-dA”” pairs. The increase in silver ion mediated base-pair stability was reversed by annulation of a pyrrole ring to the cytosine moiety, as shown for 2′-fluorinated phPyrGem in comparison with phenylpyrrolo-dC (phPyrdC). This phenomenon results from stereoelectronic effects induced by fluoro substitution, which are transmitted from the sugar moiety to the silver ion mediated base pairs. The extent of the effect depends on the number of fluorine substituents, their configuration, and the structure of the nucleobase. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8SDS of cas: 56632-83-8).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.SDS of cas: 56632-83-8

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8

Activation Pathway of a Nucleoside Analog Inhibiting Respiratory Syncytial Virus Polymerase was written by Jordan, Paul C.; Stevens, Sarah K.; Tam, Yuen; Pemberton, Ryan P.; Chaudhuri, Shuvam; Stoycheva, Antitsa D.; Dyatkina, Natalia; Wang, Guangyi; Symons, Julian A.; Deval, Jerome; Beigelman, Leo. And the article was included in ACS Chemical Biology on January 20,2017.Safety of 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one The following contents are mentioned in the article:

Human respiratory syncytial virus (RSV) is a neg.-sense RNA virus and a significant cause of respiratory infection in infants and the elderly. No effective vaccines or antiviral therapies are available for the treatment of RSV. ALS-8176 is a first-in-class nucleoside prodrug inhibitor of RSV replication currently under clin. evaluation. ALS-8112, the parent mol. of ALS-8176, undergoes intracellular phosphorylation, yielding the active 5′-triphosphate metabolite. The host kinases responsible for this conversion are not known. Therefore, elucidation of the ALS-8112 activation pathway is key to further understanding its conversion mechanism, particularly given its potent antiviral effects. Here, we have identified the activation pathway of ALS-8112 and show it is unlike other antiviral cytidine analogs. The first step, driven by deoxycytidine kinase (dCK), is highly efficient, while the second step limits the formation of the active 5′-triphosphate species. ALS-8112 is a 2′- and 4′-modified nucleoside analog, prompting us to investigate dCK recognition of other 2′- and 4′-modified nucleosides. Our biochem. approach along with computational modeling contributes to an enhanced structure-activity profile for dCK. These results highlight an exciting potential to optimize nucleoside analogs based on the second activation step and increased attention toward nucleoside diphosphate and triphosphate prodrugs in drug discovery. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Safety of 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Safety of 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8

Activities of 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodocytosine and its metabolites against herpes simplex virus types 1 and 2 in cell culture and in mice infected intracerebrally with herpes simplex virus type 2 was written by Schinazi, Raymond F.; Fox, Jack J.; Watanabe, Kyoichi A.; Nahmias, Andre J.. And the article was included in Antimicrobial Agents and Chemotherapy on January 31,1986.Name: 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one The following contents are mentioned in the article:

As measured by plaque and yield reduction assays, several metabolites of 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodocytosine (FIAC) were highly active against herpes simplex virus types 1 and 2. These metabolites included the 2′-deoxy-2′-fluoroarabinosyl derivatives of 5-iodouracil, cytosine, uracil, and thymine. In mice inoculated intracerebrally with herpes simplex virus type 2, the relative order of potency of these compounds and known antiviral drugs were as follows: 2′-fluoro-5-methylarabinosyluracil (FMAU) [69256-17-3] ≫ 2′-fluoro-5-iodoarabinosylcytosine (FIAC) [69123-90-6] ≈ 2′-fluoro-5-iodoarabinosyluracil (FIAU) [69123-98-4] > acyclovir ≈ vidarabine ≫ 2′-fluoroarabinosylcytosine (FAC) [56632-83-8] ≈ 2′-fluoroarabinosyluracil (FAU) [69123-94-0]. One of the main metabolites of FMAU, 2′-fluoro-5-hydroxymethylarabinosyluracil  [94817-51-3], was essentially inactive in vivo. FIAC-, FIAU-, FMAU-, FAC-, and FAU-resistant herpes simplex virus variants prepared in cell culture were found to be (i) devoid of viral thymidine kinase  [9002-06-6], (ii) cross-resistant to one another and resistant to drugs requiring viral thymidine kinase for activation, and (iii) sensitive to vidarabine or phosphonoformate. These results indicate that FIAC, FIAU, and FMAU require the virally encoded thymidine kinase for activation and suggest that the antiviral activity of FAU and FAC in cell cultures is also mediated by this enzyme. The interaction of the fluoroarabinosylpyrimidine nucleosides with herpes simplex virus thymidine kinase in a cell-free system is also described. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Name: 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Name: 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8

Structure-activity relationship of ligands of the pyrimidine nucleoside phosphorylases was written by Niedzwicki, John G.; El Kouni, Mahmoud H.; Chu, Shih Hsi; Cha, Sungman. And the article was included in Biochemical Pharmacology on February 1,1983.Category: pyrimidines The following contents are mentioned in the article:

Eighty-seven pyrimidine base and nucleoside analogs were evaluated as inhibitors of uridine phosphorylase (UrdPase) [289-95-2] and thymidine phosphorylase (dThdPase) [9030-23-3]. These findings, together with an extensive literature review, have allowed construction of structure-activity relationships for the binding of ligands to UrdPase and dThdPase and provide a basis for the rational design of new inhibitors of these enzymes. Addnl., 2,6-pyridinediol  [626-06-2] and 6-benzyl-2-thiouracil  [6336-50-1] were identified as being potent inhibitors of UrdPase and dThdPase, resp. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Category: pyrimidines).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Category: pyrimidines

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8

Separation of 2-fluoro-2-deoxyarabinofuranosylpyrimidine nucleosides by high-performance liquid chromatography was written by Feinberg, Aaron. And the article was included in Journal of Chromatography on June 19,1981.Category: pyrimidines The following contents are mentioned in the article:

Six 2-fluoro-2-deoxyarabinofuranosylpyrimidine nucleotides were separated using reversed-phase high-performance liquid chromatog. with Partisil ODS-1 and ODS-3. Separation was obtained by eluting isocratically with 0.01M sodium phosphate, pH 5.3, containing 4% MeOH for 5 min, followed by isocratic elution with the same buffer in 20% MeOH. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Category: pyrimidines).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Category: pyrimidines

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8

An improved synthesis of 2′-fluoro-2′-deoxyarabinofuranosyl pyrimidine nucleosides was written by Chun, Moon Woo. And the article was included in Archives of Pharmacal Research on June 30,1983.Recommanded Product: 56632-83-8 The following contents are mentioned in the article:

Nucleosides I (R = Ac; R1 = Bz; R2 = H, iodo, Br, F; 64-82% yield) and II (R = Ac; R1 = Bz; R2 = Me, F; yield 51 and 48%) were prepared by treating the corresponding trimethylsilylated bases with 3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-D-arabinofuranosyl bromide and NaI in ClCH2CH2Cl and MeCN for 3 days at room temperature Deacylation with NH3-MeOH gave I and II (R = R1 = H). I and II are potential antiherpes agents. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Recommanded Product: 56632-83-8).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Recommanded Product: 56632-83-8

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8

The Design, Synthesis, and Antiviral Activity of Monofluoro and Difluoro Analogues of 4′-Azidocytidine against Hepatitis C Virus Replication: The Discovery of 4′-Azido-2′-deoxy-2′-fluorocytidine and 4′-Azido-2′-dideoxy-2′,2′-difluorocytidine was written by Smith, David B.; Kalayanov, Genadiy; Sund, Christian; Winqvist, Anna; Maltseva, Tatiana; Leveque, Vincent J.-P.; Rajyaguru, Sonal; Le Pogam, Sophie; Najera, Isabel; Benkestock, Kurt; Zhou, Xiao-Xiong; Kaiser, Ann C.; Maag, Hans; Cammack, Nick; Martin, Joseph A.; Swallow, Steven; Johansson, Nils Gunnar; Klumpp, Klaus; Smith, Mark. And the article was included in Journal of Medicinal Chemistry on May 14,2009.COA of Formula: C9H12FN3O4 The following contents are mentioned in the article:

The discovery of 4′-azidocytidine (R1479) (J. Biol. Chem.2006, 281, 3793; Bioorganic Med. Chem. Lett. 2007, 17, 2570) as a potent inhibitor of RNA synthesis by NS5B (EC50 = 1.28 μM), the RNA polymerase encoded by hepatitis C virus (HCV), has led to the synthesis and biol. evaluation of several monofluoro and difluoro derivatives of 4′-azidocytidine. The most potent compounds in this series were 4′-azido-2′-deoxy-2′,2′-difluorocytidine I (R = F) and 4′-azido-2′-deoxy-2′-fluoroarabinocytidine I (R = H) with antiviral EC50 of 66 nM and 24 nM in the HCV replicon system, resp. The structure-activity relationships within this series were discussed, which led to the discovery of these novel nucleoside analogs with the most potent compound, showing more than a 50-fold increase in antiviral potency as compared to 4′-azidocytidine (R1479). This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8COA of Formula: C9H12FN3O4).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.COA of Formula: C9H12FN3O4

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8

Kinetics and substrate specificity of human and canine cytidine deaminase was written by Fanucchi, Michael P.; Watanabe, Kyoichi A.; Fox, Jack J.; Chou, Ting Chao. And the article was included in Biochemical Pharmacology on April 1,1986.Name: 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one The following contents are mentioned in the article:

The reaction kinetics and specificity of human and canine liver cytidine deaminase (I) for the virucide 1-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl)-5-iodocytosine (FIAC) and some other 5-substituted arabinofuranosylcytosine analogs are reported. The Km and Vmax values of human and canine I for FIAC differed significantly; marked kinetic differences of human and canine I were also observed with cytidine, deoxycytidine, arabinofuranosylcytidine, and deoxyfluoroarabinofuranosylcytosine. Studies with human I showed that substitution at the 5-position affected enzyme activity. Thus, although deoxyfluoroarabinofuranosylethylcytosine is a potent antiviral compound in vitro, it was not deaminated by human I. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Name: 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Name: 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8