Category: 56632-83-8

Synthesis and some properties of modified oligonucleotides. 2. Oligonucleotides containing 2′-deoxy-2′-fluoro-β-D-arabinofuranosylpyrimidine nucleotides was written by Kois, Pavol; Tocik, Zdenek; Spassova, Maria; Ren, Wu Yun; Rosenberg, Ivan; Soler, Jaume Farras; Watanabe, Kyoichi A.. And the article was included in Nucleosides & Nucleotides on December 31,1993.Electric Literature of C9H12FN3O4 The following contents are mentioned in the article:

In order to find the effects of unnatural nucleosides on the stability of duplex, several oligonucleotides containing 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-uracil (FAU), -cytosine (FAC) and -thymine (FMAU) were synthesized by two alternative approaches: phosphoramidite method on an ABI 392 synthesizer and H-phosphonate procedure on the authors’ GeneSyn I universal module synthesizer. It was shown from the melting profiles that the presence of FMAU has a large stabilizing effect on the duplex. Replacement of thymidine with FAU, or deoxycytidine with FAC resulted in the formation of less stable duplexes. Temperature-dependent CD spectroscopy demonstrated that the structures of the fluorine containing oligomers are very similar to those of unmodified oligomers. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Electric Literature of C9H12FN3O4).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Electric Literature of C9H12FN3O4

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8

Efficient and Accurate Potential Energy Surfaces of Puckering in Sugar-Modified Nucleosides was written by Mattelaer, Charles-Alexandre; Mattelaer, Henri-Philippe; Rihon, Jerome; Froeyen, Matheus; Lescrinier, Eveline. And the article was included in Journal of Chemical Theory and Computation on June 8,2021.Category: pyrimidines The following contents are mentioned in the article:

Puckering of the sugar unit in nucleosides and nucleotides is an important structural aspect that directly influences the helical structure of nucleic acids. The preference for specific puckering modes in nucleic acids can be analyzed via in silico conformational anal., but the large amount of conformations and the accuracy of the anal. leads to an extensive amount of computational time. In this paper, we show that the combination of geometry optimizations with the HF-3c method with single point energies at the RI-MP2 level results in accurate results for the puckering potential energy surface (PES) of DNA and RNA nucleosides while significantly reducing the necessary computational time. Applying this method to a series of known xeno nucleic acids (XNAs) allowed us to rapidly explore the puckering PES of each of the resp. nucleosides and to explore the puckering PES of six-membered modified XNA (HNA and β-homo-DNA) for the first time. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Category: pyrimidines).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Category: pyrimidines

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8

The inhibition of ultraviolet radiation-induced DNA repair in human diploid fibroblasts by arabinofuranosyl nucleosides was written by Snyder, Ronald D.; Van Houten, Bennett; Regan, James D.. And the article was included in Chemico-Biological Interactions on June 30,1984.Related Products of 56632-83-8 The following contents are mentioned in the article:

The antiviral compounds 9-β-D-arabinofuranosyladenine (ara-A), 9-β-D-arabinofuranosyl-2-fluoroadenine (FAA), 9-β-D-arabinofuranosylhypoxanthine (ara-Hx), 9-β-D-arabinofuranosylguanine (ara-G), 1-β-D-arabinofuranosylthymine (ara-T), 1-β-D-arabinofuranosyl-2′-fluorocytosine (FAC), 1-β-D-arabinofuranosyl-2′-fluoro-5-iodocytosine (FIAC), and 1-β-D-arabinofuranosyl-2′-fluoro-5-methyluracil (FMAU) were compared to 1-β-D-arabinofuranosyl cytosine (ara-C) in their ability to inhibit UV light-induced DNA repair in log phase and confluent human diploid fibroblasts. Inhibition of the polymerization or ligation steps of DNA excision repair manifests itself in the form of DNA single-strand breaks which may be quantitated through velocity sedimentation anal. in alk. sucrose gradients. In UV-irradiated quiescent, confluent human fibroblast cultures, treatment with any of the aranucleosides leads to accumulation of single-strand breaks but the ED for this inhibition varies greatly. The order of their effectiveness in confluent cultures was ara-C and its derivatives >ara-A, FAA, ara-G, Ara-HX > ara-T. In rapidly cycling cells, on the other hand, sensitivity to repair inhibition was exhibited only in response to ara-C and FAC. If 2 mM hydroxyurea (HU) was administered with ara-A, FAA, or FMAU, however, DNA strand breaks were seen. HU also increased the efficiencies of ara-C and FAC. No strand breaks were observed in UV-irradiated log-phase cells treated with FIAC, ara-Hx, ara-G, or ara-T even in the presence of HU. The efficiencies of inhibition of unscheduled DNA synthesis (UDS) and semiconservative DNA synthesis by the aranucleosides is consistent with their relative efficiencies at producing strand breaks. The ability of the aranucleosides to inhibit DNA is discussed with respect to their hypothesized effects on DNA metabolic processes in eukaryotic cells. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Related Products of 56632-83-8).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Related Products of 56632-83-8

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8

Synthesis and anti-HCV activity of 3′,4′-oxetane nucleosides was written by Chang, Wonsuk; Du, Jinfa; Rachakonda, Suguna; Ross, Bruce S.; Convers-Reignier, Serge; Yau, Wei T.; Pons, Jean-Francois; Murakami, Eisuke; Bao, Haiying; Steuer, Holly Micolochick; Furman, Phillip A.; Otto, Michael J.; Sofia, Michael J.. And the article was included in Bioorganic & Medicinal Chemistry Letters on August 1,2010.Product Details of 56632-83-8 The following contents are mentioned in the article:

Hepatitis C virus afflicts approx. 180 million people worldwide and currently there are no direct acting antiviral agents available to treat this disease. Our first generation nucleoside HCV inhibitor, RG7128 has already established proof-of-concept in the clinic and is currently in phase IIb clin. trials. As part of our continuing efforts to discover novel anti-HCV agents, 3′,4′-oxetane cytidine and adenosine nucleosides were prepared as inhibitors of HCV RNA replication. These nucleosides were shown not to be inhibitors of HCV as determined in a whole cell subgenomic replicon assay. However, 2′-mono/diflouro analogs were readily phosphorylated to their monophosphate metabolites by deoxycytidine kinase and their triphosphate derivatives were shown to be inhibitors of HCV NS5B polymerase in vitro. Lack of anti-HCV activity in the replicon assay may be due to the inability of the monophosphates to be converted to their corresponding diphosphates. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Product Details of 56632-83-8).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Product Details of 56632-83-8

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8

Synthesis and anti-HIV-1 activity of 2′-“”up””-fluoro analogs of active anti-AIDS nucleosides 3′-azido-3′-deoxythymidine (AZT) and 2′,3′-dideoxycytidine (DDC) was written by Watanabe, Kyoichi A.; Harada, Kazuho; Zeidler, Joanna; Matulic-Adamic, Jasenka; Takahashi, Kiyobumi; Ren, Wu Yun; Cheng, Ling Chin; Fox, Jack J.; Chou, Ting Chao. And the article was included in Journal of Medicinal Chemistry on August 31,1990.Synthetic Route of C9H12FN3O4 The following contents are mentioned in the article:

1-(3-Azido-2,3-dideoxy-2-fluoro-β-D-arabinofuranosyl)thymine (I) and 1-(2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl)cytosine (II) were synthesized from the potent antiherpes virus nucleosides 1-(2-fluoro-β-D-arabinofuranosyl)thymine and 1-(2-fluoro-β-D-arabinofuranosyl)-5-iodocytosine in the hope that introduction of a 2′-“”up””-fluoro substituent might potentiate the anti-HIV activity of 3′-azido-3′-deoxythymidine (AZT) and 2′,3′-dideoxycytidine. I did not exhibit any significant activity against the human immunodeficiency virus (HIV) in vitro. II, however, showed activity against HIV-1, but the therapeutic index was much inferior to that of AZT. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Synthetic Route of C9H12FN3O4).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Synthetic Route of C9H12FN3O4

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8

Synthesis and antiviral activity of monofluoro and difluoro analogs of pyrimidine deoxyribonucleosides against human immunodeficiency virus (HIV-1) was written by Martin, Joseph A.; Bushnell, David J.; Duncan, Ian B.; Dunsdon, Stephen J.; Hall, Michael J.; Machin, Peter J.; Merrett, John H.; Parkes, Kevin E. B.; Roberts, Noel A.. And the article was included in Journal of Medicinal Chemistry on August 31,1990.Related Products of 56632-83-8 The following contents are mentioned in the article:

2′-Fluoro and 2′,3′-difluoro analogs of pyrimidine deoxyribonucleosides were synthesized and evaluated against HIV-1 in a human lymphoblastoid cell line. Among these compounds, (dideoxyfluoropentofuranosyl)cytosine I (R = H), didehydrodideoxyfluorocytidine II, (dideoxydifluorofuranosyl)cytosine I (R = F) and deoxydidehydrofluorothymidine III were found to have significant antiviral activity, with inhibiting concentration50 values of 0.65, 10, 10, and 100 μM, resp. The structure-activity relationships are discussed. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Related Products of 56632-83-8).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Related Products of 56632-83-8

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8

Synthesis of fiacitabine (FIAC) was written by Xu, Shao-hong; Zhang, Wei. And the article was included in Huaxue Shiji on August 15,2011.Formula: C9H12FN3O4 The following contents are mentioned in the article:

Fiacitabine was synthesized from cytidine by protection with Ac2O and selective deprotection with hydrazine hydrate to give 3′,5′-2-O-acetyl-β-D-furanosylcytidine, which was subjected to reaction with diethylaminosulfur trifluoride, deprotection with NH3/CH3OH and then iodination under microwave irradiation with an overall yield of about 42.3%. The structure of product was confirmed by 1HNMR and 13CNMR. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Formula: C9H12FN3O4).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Formula: C9H12FN3O4

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8

Antitumor activity of a novel orally effective nucleoside, 1-(2-deoxy-2-fluoro-4-thio-β-D-arabinofuranosyl)cytosine was written by Miura, Shinji; Yoshimura, Yuichi; Endo, Mikari; Machida, Haruhiko; Matsuda, Akira; Tanaka, Motohiro; Sasaki, Takuma. And the article was included in Cancer Letters (Shannon, Ireland) on July 3,1998.Application of 56632-83-8 The following contents are mentioned in the article:

The antitumor activity of 1-(2-deoxy-2-fluoro-4-thio-β-D-arabinofuranosyl)cytosine (thio-FAC) was evaluated. Thio-FAC inhibited the in vitro growth of various human cancer cell lines, particularly the growth of cell lines established from gastric and colorectal carcinomas, while its oxy-type congener 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)cytosine (FAC) showed little or no activity against such solid cancer cell lines. Thio-FAC showed remarkable antitumor effects against human tumors s.c. implanted in nude mice and was highly effective even by oral administration. Thio-FAC was less susceptible to deamination by cytidine deaminase than FAC and 2′-deoxy-2′,2′-difluorocytidine (gemcitabine) and therefore is a promising drug for cancer chemotherapy. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Application of 56632-83-8).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Application of 56632-83-8

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8

The separation and detection of PET tracers via capillary electrophoresis for chemical identity and purity analysis was written by Cheung, Shilin; Ly, Jimmy; Lazari, Mark; Sadeghi, Saman; Keng, Pei Yuin; van Dam, R. Michael. And the article was included in Journal of Pharmaceutical and Biomedical Analysis on June 30,2014.HPLC of Formula: 56632-83-8 The following contents are mentioned in the article:

CE coupled with UV detection was assessed as a possible platform for the chem. identity and purity anal. of positron emission tomog. (PET) tracers using [18F]FAC and [18F]FLT as examples. Representative samples containing mixtures of the tracers plus well-known impurities, as well as real radioactive samples (formulated for injection), were analyzed. Using MEKC with SDS in a neutral phosphate buffer, the separation of all compounds in the samples was achieved with baseline resolutions in less than 4.5 min and 3 min for FLT and FAC samples, resp. In comparison to the gold-standard for chem. anal. (i.e. HPLC/UV), we have demonstrated improvements in anal. times, and comparable LOD. Although the reproducibility in migration time is slightly lower than that of the HPLC, identification of the compounds was still possible due to good peak separation In addition, we show that CE can be used to identify and quantify Krytofix2.2.2 (a toxic and commonly used phase transfer catalyst) in less than 2 min and with a LOD of 45 μg/mL (non-optimized). These results demonstrate adequate performance for chem. identity and purity anal. Combined with the potential for miniaturization into a microchip format, these results suggest the potential of CE as an integral part of a miniaturized quality control system for PET tracers. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8HPLC of Formula: 56632-83-8).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.HPLC of Formula: 56632-83-8

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8

Stabilization of i-motif structures by 2′-β-fluorination of DNA was written by Abou Assi, Hala; Harkness, Robert W.; Martin-Pintado, V. Nerea; Wilds, Christopher J.; Campos-Olivas, Ramon; Mittermaier, Anthony K.; Gonzalez, Carlos; Damha, Masad J.. And the article was included in Nucleic Acids Research on June 20,2016.Category: pyrimidines The following contents are mentioned in the article:

I-Motifs are four-stranded DNA structures consisting of two parallel DNA duplexes held together by hemi-protonated and intercalated cytosine base pairs (C:CH+). They have attracted considerable research interest for their potential role in gene regulation and their use as pH responsive switches and building blocks in macromol. assemblies. At neutral and basic pH values, the cytosine bases deprotonate and the structure unfolds into single strands. To avoid this limitation and expand the range of environmental conditions supporting i-motif folding, we replaced the sugar in DNA by 2-deoxy-2- fluoroarabinose. We demonstrate that such a modification significantly stabilizes i-motif formation over a wide pH range, including pH 7. NMR experiments reveal that 2-deoxy-2- fluoroarabinose adopts a C2′-endo conformation, instead of the C3′-endo conformation usually found in unmodified i-motifs. Nevertheless, this substitution does not alter the overall i-motif structure. This conformational change, together with the changes in charge distribution in the sugar caused by the electroneg. fluorine atoms, leads to a number of favorable sequential and inter-strand electrostatic interactions. The availability of folded i-motifs at neutral pH will aid investigations into the biol. function of i-motifs in vitro, and will expand i-motif applications in nanotechnol. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Category: pyrimidines).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Category: pyrimidines

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8