Category: 56843-79-9

Related Products of 56843-79-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.56843-79-9, name is 4-Chloro-2-methylthieno[2,3-d]pyrimidine, molecular formula is C7H5ClN2S, molecular weight is 184.65, as common compound, the synthetic route is as follows.

Example 31 : 6,6-dimethyl-3-[(2-methylthieno[2,3-d]pyrimidin-4-yl)amino]-N-[trans-2- phenylcyclopropyl]-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide; A mixture of compound 4b (83 mg, 0.267 mmol) and compound 31c (4-chloro-2-methylthieno[2,3- d]pyrimidine, prepared following same method compound 32c was prepared, 115 mg, 2 eq,) was added an aqueous solution of acetic acid (50% v/v, 1 ml). The resulted mixture was heated and stirred at 1000C for 1 hour. Preparative HPLC purification give the title compound as a white solid (34 mg, 27% yield). 1H EPO NMR (CD3OD) delta: 1.03-1.13 (m, 2 H), 1.69 (s, 3 H), 1.70 (s, 3 H), 1.90-1.99 (m, 1 H), 2.66 (s, 3 H), 2.67-2.75 (m, 1 H), 4.46 (s, 2 H), 6.98-7.19 (m, 5 H), 7.55-7.61 (m, 1 H) 7.63-7.69 (m, 1 H), 8.20 (d, J=6.06 Hz,1 H). LCMS (APCI, M+H+): 460.1. Anal. (C24H25N7OS-LSITFA-O-I SH2O): C, H, N. HPLC-UV Detection:95% purity.

Statistics shows that 56843-79-9 is playing an increasingly important role. we look forward to future research findings about 4-Chloro-2-methylthieno[2,3-d]pyrimidine.

Reference:
Patent; PFIZER INC.; WO2006/72831; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 56843-79-9, name is 4-Chloro-2-methylthieno[2,3-d]pyrimidine, the common compound, a new synthetic route is introduced below. name: 4-Chloro-2-methylthieno[2,3-d]pyrimidine

General procedure: Compounds 9-12 or 22-24 (1 equiv.) and corresponding chorides (1.2 equiv.) in AcOH/H2O:1/1 (20ml) were heated to 50C. When TLC analysis showed the complete conversion of the starting material, sodium hydroxide (2 equiv.) was added to the mixture. Then, the reaction mixture was extracted with ethyl acetate. After removal of the solvent, compounds 33-43 were purified by column chromatography and the corresponding compounds were obtained. Compounds 25-32 were used without further purification.

The synthetic route of 56843-79-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhi, Yanle; Li, Baoquan; Yao, Chao; Li, Hongmei; Chen, Puzhou; Bao, Jiyin; Qin, Tianren; Wang, Yue; Lu, Tao; Lu, Shuai; European Journal of Medicinal Chemistry; vol. 155; (2018); p. 303 – 315;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 56843-79-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 56843-79-9, name is 4-Chloro-2-methylthieno[2,3-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

A clear solution of 4-chloro-2-methylthieno[2,3-djpyrimidine (30 mg, 0.l62mmol), 4,4,4- trifluorobutylamine (55 tL, 0.486 mmol), DIEA (35 tL, 0.20 mmol), and dry p-dioxane (0.5 mL) was heated at 140 C for 90 minutes in a microwave reactor. A yellow solution formed, which was partitioned between DCM and water. The DCM layer was separated and set aside, and the aqueous layer was washed with ethyl acetate. Both organic layers were combined and concentrated undervacuum to afford a viscous yellow substance, which was lyophilized for 2 hours to give the final product(37 mg, 83% yield). LC-MS analysis indicated the desired product with >97% purity and mass: m/z 276(M+H). Calcd for C11H12F3N3S=275.29. 1H NMR (400MHz, DMSO-d6) oe 7.87 (t, J = 5.4 Hz, 4 H), 7.53(d, J = 5.9 Hz, 5 H), 7.43 (d, J = 5.9 Hz, 1 H), 3.60 – 3.51 (m, 10 H), 2.43 (s, 3 H), 2.40 -2.30 (m, 9 H),1.93 – 1.74 (m, 10 H).

According to the analysis of related databases, 56843-79-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SAINT LOUIS UNIVERSITY; WASHINGTON UNIVERSITY; MEYERS, Marvin, J.; SINGH, Megh; STALLINGS, Christina, L.; WEISS, Leslie, A.; WILDMAN, Scott; ARNETT, Stacy, D.; (134 pag.)WO2019/18359; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 56843-79-9, name is 4-Chloro-2-methylthieno[2,3-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 56843-79-9

General procedure: The synthesis of target compound 2-11 (Scheme 1), commenced from commercially available ethyl-2-amino-3-thiophenecarboxylate (12a, Ri= H) and ethyl-2-amino-4,5-dimethyl-3- thiophenecarboxylate obtained using a reported method. Cyclization of 12a and 12b with HC1 (g) and acetonitrile gave 13a and 13b followed by chlorination with POCl3 afforded 14a and 14b respectively. Treatment with various substituted anilines in dioxane with 2 drops of cone HC1 provided 2-11. (60 -76 % yields).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 56843-79-9, 4-Chloro-2-methylthieno[2,3-d]pyrimidine.

Reference:
Patent; DUQUESNE UNIVERSITY OF THE HOLY SPIRIT; GANGJEE, Aleem; (140 pag.)WO2017/31176; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 56843-79-9, name is 4-Chloro-2-methylthieno[2,3-d]pyrimidine, the common compound, a new synthetic route is introduced below. Computed Properties of C7H5ClN2S

General conditions1: Chloropyrimidine 5 (0.45 mmol) and aminopyrazole 6 (0.30 mmol) were mixed in 1:1 acetic acid/water solution (1.4 mL) or in glacial acetic acid (1.4 mL) and stirred at 100 C in an oil bath for 1 h (or 50 C for 4 h or 25 C for 18 h). The mixture was neutralized by the addition of ice-cold 5% NaOH solution (10 mL) and extracted with methylene chloride (3 ¡Á 25 mL). Combined organic layers were dried and concentrated. The residue was further purified by normal phase flash chromatography (Biotage, for cPropylphenyl analogs R = C) or reversed phase preparative HPLC (analogs with free amines R = A or B), affording the desired aminopyrimidines (7-30).

The synthetic route of 56843-79-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Guo, Chuangxing; Dong, Liming; Marakovits, Joseph; Kephart, Susan; Tetrahedron Letters; vol. 52; 14; (2011); p. 1692 – 1696;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 56843-79-9, name is 4-Chloro-2-methylthieno[2,3-d]pyrimidine. A new synthetic method of this compound is introduced below., COA of Formula: C7H5ClN2S

General procedure: Compounds 9-12 or 22-24 (1 equiv.) and corresponding chorides (1.2 equiv.) in AcOH/H2O:1/1 (20ml) were heated to 50C. When TLC analysis showed the complete conversion of the starting material, sodium hydroxide (2 equiv.) was added to the mixture. Then, the reaction mixture was extracted with ethyl acetate. After removal of the solvent, compounds 33-43 were purified by column chromatography and the corresponding compounds were obtained. Compounds 25-32 were used without further purification.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 56843-79-9, 4-Chloro-2-methylthieno[2,3-d]pyrimidine.

Reference:
Article; Zhi, Yanle; Li, Baoquan; Yao, Chao; Li, Hongmei; Chen, Puzhou; Bao, Jiyin; Qin, Tianren; Wang, Yue; Lu, Tao; Lu, Shuai; European Journal of Medicinal Chemistry; vol. 155; (2018); p. 303 – 315;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia