Reference of 57005-71-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 57005-71-7, name is 2-(4-Methylpiperazin-1-yl)pyrimidin-4-amine. This compound has unique chemical properties. The synthetic route is as follows.
A procedure similar to Example 59 (Method B), Parts A and B was used, except that 2-(4-methyl-1-piperazinyl)-4-pyrimidinamine (81 mg, 0.419 mmol) was used instead of 4-pyrimidinamine to add to the reaction mixture in Part A, to provide the Title compound. MS (ES+) m/z 489.2 (MH+). 1H NMR (400 MHz, METHANOL-d4) delta ppm 1.15 (dd, J=11.24, 7.20 Hz, 2H) 1.33-1.44 (m, 1H) 1.46-1.68 (m, 4H) 1.69-1.97 (m, 4H) 2.14-2.28 (m, 1H) 2.33 (s, 3H) 2.48 (t, J=5.05 Hz, 5H) 2.79-2.98 (m, 1H) 3.18-3.29 (m, 1H) 3.49 (dd, J=13.89, 4.55 Hz, 1H) 3.70-3.86 (m, 5H) 3.93 (tt, J=9.54, 4.86 Hz, 1H) 4.60-4.75 (m, 1H) 7.32 (d, J=5.56 Hz, 1H) 7.85 (s, 0.7H) 8.19 (d, J=5.56 Hz, 1H) 8.25 (s, 0.3H)
According to the analysis of related databases, 57005-71-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Glaxosmithkline LLC; Aubart, Kelly M.; Benowitz, Andrew B.; Fang, Yuhong; Hoffman, James; Karpinski, Joseph M.; Knox, Andrew Nicholson; Liao, Xiangmin; Qin, Donghui; Shi, Dongchuan; Spletstoser, Jared T.; US2013/345120; (2013); A1;; ; Patent; GlaxoSmithKline Intellectual Property (No. 2) Limited; Aubart, Kelly M.; Benowitz, Andrew B.; Fang, Yuhong; Hoffman, James; Karpinski, Joseph M.; Knox, Andrew Nicholson; Liao, Xiangmin; Qin, Donghui; Shi, Dongchuan; Spletstoser, Jared T.; US8901119; (2014); B2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia