Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5734-66-7, name is 2-Amino-6-ethylpyrimidin-4-ol. This compound has unique chemical properties. The synthetic route is as follows. category: pyrimidines
A. 2-Amino-5-bromo-6-ethyl-4-pyrimidinol By bromination of 6-ethyl-isocytosine with N-bromosuccinimide To a faintly warm solution of 1.112 g. (8.0 millimoles) of 6-ethyl-isocytosine in 16 ml. of glacial acetic acid is added 1.424 g. (8.0 millimoles) of N-bromosuccinimide. The reaction flask is closed with a drying tube, and the mixture heated briefly on a steam bath, with occasional swirling, until solution is complete. The solution is heated on a steam bath for 1 hour, then allowed to cool spontaneously. The cooled solution is seeded with crystals from an earlier run and kept at ambient temperature for several days. The resulting crystals are collected, washed first with cool glacial acetic acid then with anhydrous ether. The material is dried, first in air then in vacuo at 76C. for several hours. The crude material, 960 mg., is crystallized from about 20 ml. of 50% aqueous acetic acid, using decolorizing charcoal. The product is collected, washed successively with cold 50% aqueous acetic acid, cold 95% ethanol and anhydrous ether. The pure material, after brief airdrying, is dried in vacuo at ca. 80C. There is thus obtained 660 mg. of 2-amino-5-bromo-6-ethyl-4-pyrimidinol which melts at 225 to 225.5 centigrade, has a lambdamax0.1N NaOH 230.5 nm. (epsilon8,200); 283 nm. (epsilon7,200) and the infrared absorption below. Nh/oh, 3380, 3320, 3130, 2720; c=o/c=n/c=c, 1675, 1640, 1610, 1565; c–o/c–n other, 1340, 1310, 1215, 1060, 1005 cm-1. Analysis Calcd. for: C6 H8 BrN3 O: C, 33.05; H, 3.17; Br, 36.65; N, 19.27.Found: C, 32.98; H, 3.63; Br, 36.75; N, 18.81.
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Reference:
Patent; The Upjohn Company; US3956302; (1976); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia