Shinozuka, Kazuo’s team published research in Inorganica Chimica Acta in 100 | CAS: 5738-14-7

Inorganica Chimica Acta published new progress about 5738-14-7. 5738-14-7 belongs to pyrimidines, auxiliary class Pyrimidine,Amine,Alcohol,Pyrimidine, name is 2-(Dimethylamino)pyrimidine-4,6-diol, and the molecular formula is C6H17NO3Si, Product Details of C6H9N3O2.

Shinozuka, Kazuo published the artcileNucleoside complexing. A carbon-13 NMR spectroscopic investigation of the metal binding sites in 7-methylguanosine, 7-methylinosine and some related new synthetic betaines, Product Details of C6H9N3O2, the publication is Inorganica Chimica Acta (1985), 100(1), 141-50, database is CAplus.

A 13C NMR spectroscopic study of the binding of various metal species, including hard metal species (Sr, Ba, La, Pr), intermediate metal species (Zn, Cd, Pb), and soft metal species (Pt, Hg), is reported. The 13C NMR shift patterns for the O6 resonance of 7-methylguanosine, 7-methylinosine, 2-(dimethylamino)-7.9-dimethylhypoxanthinium betaine, 2-(diethylamino)-7-methyl-9-propylhypoxanthinium betaine, and the (ethylamino) and 6-thio analogs of the latter betaine suggest that metal species of intermediate ‘softness’ prefer endocyclic N1 binding over exocyclic O6 to a larger extent than they prefer endocyclic N3 binding over exocyclic O2 binding in cytosine derivatives 2-Dimethylamino-9-methylhypoxanthine I (R,R1 = Me; R2 = Me) was prepared from 5-amino-4,6-dihydroxy-2-dimethylaminopyrimidine II (R3 = NH2, R4 = OH, R5 = NMe2) by addition of MeNCS, ring closure with HCL, and Raney nickel desulfurization. I (R,R1 = H, Et; R2 = Pr) were prepared from II (R3 = NO2, R4 = NH2, R5 = SMe) by treatment with Me2NH, EtNH2, or Et2NH followed by cycloadditions with Na2S2O4, HCO2H2 and CHCONH2 alkylation with alkyl halides, and deamination with HNO2. I were methylated to give the corresponding hypoxanthinium betaines III.

Inorganica Chimica Acta published new progress about 5738-14-7. 5738-14-7 belongs to pyrimidines, auxiliary class Pyrimidine,Amine,Alcohol,Pyrimidine, name is 2-(Dimethylamino)pyrimidine-4,6-diol, and the molecular formula is C6H17NO3Si, Product Details of C6H9N3O2.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Walunj, Manisha B.’s team published research in Nucleic Acids Research in 46 | CAS: 5738-14-7

Nucleic Acids Research published new progress about 5738-14-7. 5738-14-7 belongs to pyrimidines, auxiliary class Pyrimidine,Amine,Alcohol,Pyrimidine, name is 2-(Dimethylamino)pyrimidine-4,6-diol, and the molecular formula is C4H5NS2, Safety of 2-(Dimethylamino)pyrimidine-4,6-diol.

Walunj, Manisha B. published the artcilePost-transcriptional labeling by using Suzuki-Miyaura cross-coupling generates functional RNA probes, Safety of 2-(Dimethylamino)pyrimidine-4,6-diol, the publication is Nucleic Acids Research (2018), 46(11), e65/1-e65/10, database is CAplus and MEDLINE.

Pd-catalyzed C-C bond formation, an important vertebra in the spine of synthetic chem., is emerging as a valuable chemoselective transformation for post-synthetic functionalization of biomacromols. While methods are available for labeling protein and DNA, development of an analogous procedure to label RNA by cross-coupling reactions remains a major challenge. Herein, we describe a new Pd-mediated RNA oligonucleotide (ON) labeling method that involves post-transcriptional functionalization of iodouridine-labeled RNA transcripts by using Suzuki-Miyaura cross-coupling reaction. 5-Iodouridine triphosphate (IUTP) is efficiently incorporated into RNA ONs at one or more sites by T7 RNA polymerase. Further, using a catalytic system made of Pd(OAc)2 and 2-aminopyrimidine- 4,6-diol (ADHP) or dimethylamino-substituted ADHP (DMADHP), we established a modular method to functionalize iodouridine-labeled RNA ONs in the presence of various boronic acid and ester substrates under very mild conditions (37°C and pH 8.5). This method is highly chemoselective, and offers direct access to RNA ONs labeled with commonly used fluorescent and affinity tags and new fluorogenic environment-sensitive nucleoside probes in a ligand-controlled stereoselective fashion. Taken together, this simple approach of generating functional RNA ON probes by Suzuki-Miyaura coupling will be a very important addition to the resources and tools available for analyzing RNA motifs.

Nucleic Acids Research published new progress about 5738-14-7. 5738-14-7 belongs to pyrimidines, auxiliary class Pyrimidine,Amine,Alcohol,Pyrimidine, name is 2-(Dimethylamino)pyrimidine-4,6-diol, and the molecular formula is C4H5NS2, Safety of 2-(Dimethylamino)pyrimidine-4,6-diol.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Dumas, Anaelle’s team published research in Angewandte Chemie, International Edition in 52 | CAS: 5738-14-7

Angewandte Chemie, International Edition published new progress about 5738-14-7. 5738-14-7 belongs to pyrimidines, auxiliary class Pyrimidine,Amine,Alcohol,Pyrimidine, name is 2-(Dimethylamino)pyrimidine-4,6-diol, and the molecular formula is C6H9N3O2, Application of 2-(Dimethylamino)pyrimidine-4,6-diol.

Dumas, Anaelle published the artcileSelf-Liganded Suzuki-Miyaura Coupling for Site-Selective Protein PEGylation, Application of 2-(Dimethylamino)pyrimidine-4,6-diol, the publication is Angewandte Chemie, International Edition (2013), 52(14), 3916-3921, database is CAplus and MEDLINE.

PEG-boronic acids, in the presence of simple Pd sources, are capable of acting as direct and effective Suzuki reagents in 70-98% yield. When combined with non-natural amino acids, they allow efficient and direct, site-selective PEGylation of proteins at predetermined positions under biol. compatible conditions without the need for exogenous ligands.

Angewandte Chemie, International Edition published new progress about 5738-14-7. 5738-14-7 belongs to pyrimidines, auxiliary class Pyrimidine,Amine,Alcohol,Pyrimidine, name is 2-(Dimethylamino)pyrimidine-4,6-diol, and the molecular formula is C6H9N3O2, Application of 2-(Dimethylamino)pyrimidine-4,6-diol.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Yuan, Libo’s team published research in Synthetic Communications in 44 | CAS: 5738-14-7

Synthetic Communications published new progress about 5738-14-7. 5738-14-7 belongs to pyrimidines, auxiliary class Pyrimidine,Amine,Alcohol,Pyrimidine, name is 2-(Dimethylamino)pyrimidine-4,6-diol, and the molecular formula is C8H8O3, Computed Properties of 5738-14-7.

Yuan, Libo published the artcileChemical labeling of 5-iodo-2′-deoxyuridine with 4-ethynyl-N-ethyl-1,8-naphthalimide using copper-free Sonogashira cross-coupling in aqueous medium, Computed Properties of 5738-14-7, the publication is Synthetic Communications (2014), 44(7), 1007-1011, database is CAplus.

The synthesis of a fluorescent nucleoside analog was reported by using a Cu-free Sonogashira cross-coupling reaction in a satisfactory yield. This reaction occurred at 37° in open air and aqueous medium and avoided the toxicity of Cu(I). The mild Sonogashira reaction provided the possibility of fluorescent labeling of nucleoside mimics in living cells.

Synthetic Communications published new progress about 5738-14-7. 5738-14-7 belongs to pyrimidines, auxiliary class Pyrimidine,Amine,Alcohol,Pyrimidine, name is 2-(Dimethylamino)pyrimidine-4,6-diol, and the molecular formula is C8H8O3, Computed Properties of 5738-14-7.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Boon, W. R.’s team published research in Journal of the Chemical Society in | CAS: 5738-14-7

Journal of the Chemical Society published new progress about 5738-14-7. 5738-14-7 belongs to pyrimidines, auxiliary class Pyrimidine,Amine,Alcohol,Pyrimidine, name is 2-(Dimethylamino)pyrimidine-4,6-diol, and the molecular formula is C6H9N3O2, Formula: C6H9N3O2.

Boon, W. R. published the artcilePteridines. IV. Derivatives of 2,4-diaminopteridine and related compounds, Formula: C6H9N3O2, the publication is Journal of the Chemical Society (1957), 2146-58, database is CAplus.

cf. C.A. 46, 2082g. Several derivatives of 2,4-(H2N)2-Y (in this abstract Y = pteridine) possess antimalarial activity (Potter and Henshall, C.A. 51, 1974h). A series of 2,4,6,7-(H2N)2Ph2-Y were prepared in which the H2N groups were progressively substituted by Me. Antimalarial activity was immediately lost, but the compounds were active against exptl. schistosomiasis in mice. Further modifications of the substituents always lowered the activity. Only a few compounds showed any appreciable activity. 2,4,6-Me2N-(HO)2-Z (in this abstract Z = pyrimidine) ground to pass a 30-mesh sieve, added with stirring during 45 min. to 280 cc. AcOH and 65 cc. HNO3 (d. 1.5) at 20-5°, stirred an addnl. 45 min., the mixture poured into 1350 cc. H2O, the solid separated, washed free from acid, and dried gave 81 g. 5-O2N derivative (I). I (5 g.), 60 cc. POCl3, and 20 cc. PhNMe2 heated to 105° (bath temperature), after the vigorous reaction the heating continued 1 hr., excess POCl3 removed in vacuo, the residue treated with 200 g. ice, the suspension extracted with four 50-cc. portions of Et2O, the combined extracts dried, filtered, evaporated, and the residue crystallized from petr. ether (b. 60-80°) gave 3.7 g. 4,6-Cl2 compound (II), m. 117-20°. II (14 g.), 90 cc. C6H6, and 10 cc. aqueous NH3 (d. 0.880) shaken overnight, the mixture filtered, and the residue (4.2 g.) crystallized twice from dioxane gave the 4,6-(H2N)2 compound, m. 249-50°; evaporation of the filtrate gave a residue which, after chromatography on 120 g. Al2O3 in 30 cc. C6H6 and crystallization from EtOAc-petr. ether afforded 0.5 g. 4-H2N compound, m. 132°. To 91 g. Na in 2 l. MeOH was added 509 g. [MeHNC(:NH)NH2]2.H2SO4, the mixture refluxed 30 min. with stirring, CH2(CO2Et)2 added, the heating continued 6 hrs., the mixture cooled, diluted with 5 l. H2O, treated with C, filtered, the filtrate acidified to litmus with AcOH, and the precipitate collected to give 183 g. 2,4,6-MeHN(HO)2-Z (III); the mother liquors deposited 15 g. presumably 2-amino-1,4,5,6-tetrahydro-1-methyl-4,6-dioxo-Z, m. above 360°. III (93g.) and 510 g. POCl3 refluxed 1 hr., the mixture filtered through sintered glass, the filtrate poured on 2250 cc. 32% aqueous NaOH and ice, the separated solid collected, washed with H2O, and crystallized from MeOH gave 88 g. 2,4,6-(MeHN)Cl2-Z (IV), m. 164°. IV (130 g.) heated 12 hrs. with NaOMe (from 168 g. Na in 570 cc. MeOH), the solution cooled, the precipitate collected, washed with H2O, and crystallized from MeOH yielded 95 g. 4,6,2-Cl(MeO)(MeHN)-Z, m. 153°. Similarly was prepared 81% 4,6,2-Cl(MeO)(Me2N)-Z (VI), m. 62° (after sublimation at 55°/0.1 mm.), from 4,6,2-Cl2(Me2N)-Z at room temperature VI (10 g.) heated 30 min. on a steam bath with 50 cc. HCl, the solution cooled, the product collected, and purified by solution in aqueous alkali, treatment with C, and reprecipitation with AcOH gave 5.5 g. 6-HO compound, m. 265° (decomposition). Similarly was obtained from VI 95% 4,6,2-Cl(HO)(Me2N)-Z (VII), m. 217°. 4,6,2-ClMe(H2N)-Z (28.7 g.) and 78 cc. 19.5% alc. Me2NH heated 17 hrs. at 110-20° gave 172 g. 4-Me2N derivative, m. 172° (from C6H6). Ph(H2N)CHCOPh.HCl (47 g.) dissolved in 750 cc. H2O. basified at 0° with aqueous NH3, the base collected, sucked as dry as possible, added to 35 g. 2,4,6-Cl3-Z (VIII) in 750 cc. EtOH, the mixture set aside 2 days at room temperature, the precipitate (12 g.) collected, and crystallized from EtOH gave α-(2,4-dichloro-6-pyrimidylamino)deoxybenzoin (IX), m. 165°. p-ClC6H4CHBzNH2 (X) (28.5 g.) converted to the base, the latter treated as above with 9 g. VIII, the crude product refluxed 3 hrs. with 10 cc. 19.5% alc. Me2NH and 10 cc. EtOH, the solution evaporated to 0.5 its volume, and the solid recrystallized from MeOH gave ω-(4-chloro-2-dimethylamino-6-pyrimidyl-amino)-ω-(p-chlorophenyl)acetophenone, m. 151-2°; the mother liquors gave the 6-Me2N isomer, m. 181-2° (from EtOH), and a small amount of another compound believed to be 2,5-di(p-chlorophenyl)-3,6-diphenylpyrazine, m. 239-40°. 4,6,2-Cl2(H2N)-Z (XI) (33 g.) heated 3 hrs. with 175 cc. 19.5% alc. Me2NH, after the initial reaction had subsided the solution cooled, the precipitate (24 g.) collected, and crystallized from MeOH and then from C6H6 gave 4,2,6-Cl(H2N)(Me2N)-Z, m. 164-5°. Similarly were obtained in 70% yield from the appropriate derivative of XI and an alc. solution of H2NCH2CO2Et, Et 4-chloro-2-methylamino-6-pyrimidylaminoacetate (XII), m. 167°, and Et 4-chloro-2-dimethylamino-6-pyrimidylamino-acetate, m. 121°. 2,4,6-Cl2(Me2N)-Z (36 g.), 200 cc. EtOH, and 50 cc. 70% aqueous EtNH2 refluxed 6 hrs., EtOH removed, the mixture diluted with H2O, extracted with Et2O, the extract dried, Et2O removed, the residue dissolved in 70 cc. absolute EtOH, 9 cc. concentrated H2SO4 added (the mixture acid to Congo red), and dry Et2O added to a permanent turbidity gave 34 g. 4,6,2-Cl(EtNH)(MeNH)-Z sulfate, m. 148° (from EtOH-Et2O). The following compounds were prepared similarly: 4,2,6-Cl(Me2N)(MeNH)-Z, m. 78° (from petr. ether); 4,2,6-Cl(Et2N)(MeNH)-Z sulfate, m. 148-9° (from EtOH-Et2O); 4-chloro-6-methylamino-2-piperidino-Z, m. 118° (from MeOH); 4,6,2-Cl(MeNH)(Me2NCH2CH2NH)-Z, m. 99° (from EtOAc-petr. ether). To 17.5 g. VII in 500 cc. H2O containing 60 cc. 2N NaOH and 12.6 g. NaHCO3 was added 4-ClC6H4N2Cl (XIII) [from 12.75 g. 4-ClC6H4NH2 (XIV)], the solution stirred overnight, the precipitate collected, washed with H2O, EtOH, and Et2O, and crystallized from dioxane to give 20 g. 5-p-ClC6H4N2 derivative (XV), m. 220-2° (decomposition). 4,6,2,5-Cl(HO)(MeNH)(p-ClC6H4N2)-Z was obtained similarly but could not be purified without decomposition XIII (500 cc. 0.025M) and 46 g. NaOAc.3H2O (XVI) added with stirring to 3.8 g. 6,4,2-Me(HO)(Me2N)-Z in 500 cc. H2O, after 16 hrs. the precipitate collected, washed, dried in air, and recrystallized from BuOH gave 5.5 g. 5-(p-ClC6H4N2) derivative, m. 216-17°. XIII (50 cc. 0.025M) and 40 g. XVI added with stirring to 5.0 g. 4,2,6-Cl(Me2N)2-Z in 70 cc. AcOH, diluted with 200 cc. H2O, after 48 hrs. stirring the solid collected, washed with H2O, and crystallized twice from EtOH gave 5 g. 5-(p-ClC6H4N2) derivative (XVII), m. 91°. The following N.CX:N.CW:C(N:NR).CY (XVIII) (W = Cl) were prepared (X, Y, R, m.p., crystallization solvent, % yield given): NH2, NHMe, p-ClC6H4, 255°, HCONMe (XIX), 47; NH2, NMe2, p-ClC6H4, 204°, XIX-EtOH, 65; NHMe, NH2, p-ClC6H4, 272° (decomposition), XIX, 90; NHMe, NHMe, p-ClC6H4, 272°, XIX-EtOH, 95; NHEt, NHMe, p-ClC6H4, 214°, BuOH, 75; NMe2, NH2, p-ClC6H4, 229°, BuOH, 90; NMe2, NHMe, Ph, 163°, EtOH, 78; NMe2, NHMe, p-ClC6H4, 183°, BuOH, 90; HNCH2CH2NMe2, NHMe, p-ClC6H4, 158°, EtOH, 50. 6,4,2,5-Cl(H2N)(Me2N)(p-ClC6 H4N2)-Z (XX) (2 g.) and 40 cc. saturated alc. NH3 heated 36 hrs. at 150-60°, the solution cooled, and the product (1.75 g.) crystallized from BuOH gave 6-H2N compound, m. 272-3° [HCl salt, m. 301° (decomposition) (from 80% HCO2H) (prepared from XIII and 4,6,2-(H2N)2(Me2N)-Z in AcOH)]. Similarly were prepared the following XVIII (W = NH2, R = p-ClC6H4) (X, Y, m.p., crystallization solvent, % yield given): NH2, NHMe, 213°, BuOH, 40 and 80; NH2, NMe2, 205°, XIX-H2O, 96; NH2,

Journal of the Chemical Society published new progress about 5738-14-7. 5738-14-7 belongs to pyrimidines, auxiliary class Pyrimidine,Amine,Alcohol,Pyrimidine, name is 2-(Dimethylamino)pyrimidine-4,6-diol, and the molecular formula is C6H9N3O2, Formula: C6H9N3O2.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Boon, W. R.’s team published research in Journal of the Chemical Society in | CAS: 5738-14-7

Journal of the Chemical Society published new progress about 5738-14-7. 5738-14-7 belongs to pyrimidines, auxiliary class Pyrimidine,Amine,Alcohol,Pyrimidine, name is 2-(Dimethylamino)pyrimidine-4,6-diol, and the molecular formula is C6H9N3O2, Quality Control of 5738-14-7.

Boon, W. R. published the artcile4,6-Dichloro-2-dimethylaminopyrimidine, Quality Control of 5738-14-7, the publication is Journal of the Chemical Society (1952), 1532, database is CAplus.

Me2NC(:NH)NH2.0.5H2SO4 (91 g.), stirred 30 min. with 300 cc. boiling MeOH containing 15 g. Na, the solution treated with 116 g. CH2(CO2Et)2, refluxed 6 hrs., diluted with 450 cc. H2O, and acidified with AcOH, gives 85 g. 2-dimethylamino-4,6-dihydroxypyrimidine (I), with 3 mols. H2O, does not m. at 350°. I (15.5 g.) and 60 cc.POCl3, refluxed 35 min. and poured into 1 l. cold 2 N NaOH, give 16 g. 4,6-dichloro-2-dimethylaminopyrimidine (II), m. 54°; II also results from the reaction of 2,4,6-tri-chloropyrimidine and Me2NH on crystallization from petr. ether and aqueous MeOH (cf. King and King, C.A. 42, 1280h). I (3.8 g.) and 10 cc. 10% EtOH-NH3, heated 18 hrs. at 110-20°, give 4-amino-6-chloro-2-dimethylaminopyrimidine, m. 151°; this results also from 4-amino-2,6-dichloropyrimidine and Me2NH (10 hrs. at 80°). I and EtOH-MeNH2 or 2,4-dichloro-6-methylaminopyrimidine and alc. Me2NH give 4-chloro-2-dimethylamino-6-aminopyrimidine, b1 122-5°. Il and EtOH-Me2NH give 4-chloro-2,6-bis(dimethylamino)-pyrimidine, m. 52.2°, sublimes 56°/0.1 mm.

Journal of the Chemical Society published new progress about 5738-14-7. 5738-14-7 belongs to pyrimidines, auxiliary class Pyrimidine,Amine,Alcohol,Pyrimidine, name is 2-(Dimethylamino)pyrimidine-4,6-diol, and the molecular formula is C6H9N3O2, Quality Control of 5738-14-7.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Willwacher, Jens’s team published research in Journal of the American Chemical Society in 138 | CAS: 5738-14-7

Journal of the American Chemical Society published new progress about 5738-14-7. 5738-14-7 belongs to pyrimidines, auxiliary class Pyrimidine,Amine,Alcohol,Pyrimidine, name is 2-(Dimethylamino)pyrimidine-4,6-diol, and the molecular formula is C6H13I, Category: pyrimidines.

Willwacher, Jens published the artcileSelective Metal-Site-Guided Arylation of Proteins, Category: pyrimidines, the publication is Journal of the American Chemical Society (2016), 138(28), 8678-8681, database is CAplus and MEDLINE.

We describe palladium-mediated S-arylation that exploits natural metal-binding motifs to ensure high site selectivity for a proximal reactive residue. This allows the chem. identification not only of proteins that bind metals but also the environment of the metal-binding site itself through proteomic anal. of arylation sites. The transformation is easy to perform under standard conditions, does not require the isolation of a reactive Ar-Pd complex, is broad in scope, and is applicable in cell lysates as well as to covalent inhibition/modulation of metal-dependent enzymic activity.

Journal of the American Chemical Society published new progress about 5738-14-7. 5738-14-7 belongs to pyrimidines, auxiliary class Pyrimidine,Amine,Alcohol,Pyrimidine, name is 2-(Dimethylamino)pyrimidine-4,6-diol, and the molecular formula is C6H13I, Category: pyrimidines.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Li, Nan’s team published research in ACS Chemical Biology in 10 | CAS: 5738-14-7

ACS Chemical Biology published new progress about 5738-14-7. 5738-14-7 belongs to pyrimidines, auxiliary class Pyrimidine,Amine,Alcohol,Pyrimidine, name is 2-(Dimethylamino)pyrimidine-4,6-diol, and the molecular formula is C6H9N3O2, Name: 2-(Dimethylamino)pyrimidine-4,6-diol.

Li, Nan published the artcileA Genetically Encoded Alkyne Directs Palladium-Mediated Protein Labeling on Live Mammalian Cell Surface, Name: 2-(Dimethylamino)pyrimidine-4,6-diol, the publication is ACS Chemical Biology (2015), 10(2), 379-384, database is CAplus and MEDLINE.

The merging of site-specific incorporation of small bioorthogonal functional groups into proteins via amber codon suppression with bioorthogonal chem. has created exciting opportunities to extend the power of organic reactions to living systems. A new alkyne amino acid can be site-selectively incorporated into mammalian proteins via a known orthogonal pyrrolysyl-tRNA synthetase/tRNACUA pair and directs an unprecedented, palladium-mediated cross-coupling reaction-driven protein labeling on live mammalian cell surface. A comparison study with the alkyne-encoded proteins in vitro indicated that this terminal alkyne is better suited for the palladium-mediated cross-coupling reaction than the copper-catalyzed click chem.

ACS Chemical Biology published new progress about 5738-14-7. 5738-14-7 belongs to pyrimidines, auxiliary class Pyrimidine,Amine,Alcohol,Pyrimidine, name is 2-(Dimethylamino)pyrimidine-4,6-diol, and the molecular formula is C6H9N3O2, Name: 2-(Dimethylamino)pyrimidine-4,6-diol.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Loksha, Yasser M.’s team published research in Archiv der Pharmazie (Weinheim, Germany) in 349 | CAS: 5738-14-7

Archiv der Pharmazie (Weinheim, Germany) published new progress about 5738-14-7. 5738-14-7 belongs to pyrimidines, auxiliary class Pyrimidine,Amine,Alcohol,Pyrimidine, name is 2-(Dimethylamino)pyrimidine-4,6-diol, and the molecular formula is C6H9N3O2, Product Details of C6H9N3O2.

Loksha, Yasser M. published the artcileSynthesis and Anti-HIV-1 Evaluation of Some Novel MC-1220 Analogs as Non-Nucleoside Reverse Transcriptase Inhibitors, Product Details of C6H9N3O2, the publication is Archiv der Pharmazie (Weinheim, Germany) (2016), 349(5), 363-372, database is CAplus and MEDLINE.

Some novel MC-1220 analogs were synthesized by a condensation of 4,6-dichloro-N-methylpyrimidin-2-amine derivatives and/or 4-chloro-6-methoxy-N,N,5-trimethylpyrimidin-2-amine with the sodium salt of 2,6-difluorophenylacetonitrile followed by treatment with aqueous sodium hydroxide in methanol, alkylation, reduction, halogenation, and/or acidic hydrolysis. All synthesized compounds were evaluated for their activity against HIV-1. The most active compound in this study showed activity against HIV-1 comparable to that of MC-1220. The only difference in structure between compound 7 and MC-1220 is a fluoro atom instead of a CH3 group.

Archiv der Pharmazie (Weinheim, Germany) published new progress about 5738-14-7. 5738-14-7 belongs to pyrimidines, auxiliary class Pyrimidine,Amine,Alcohol,Pyrimidine, name is 2-(Dimethylamino)pyrimidine-4,6-diol, and the molecular formula is C6H9N3O2, Product Details of C6H9N3O2.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Li, Nan’s team published research in Journal of the American Chemical Society in 133 | CAS: 5738-14-7

Journal of the American Chemical Society published new progress about 5738-14-7. 5738-14-7 belongs to pyrimidines, auxiliary class Pyrimidine,Amine,Alcohol,Pyrimidine, name is 2-(Dimethylamino)pyrimidine-4,6-diol, and the molecular formula is C6H9N3O2, Synthetic Route of 5738-14-7.

Li, Nan published the artcileCopper-Free Sonogashira Cross-Coupling for Functionalization of Alkyne-Encoded Proteins in Aqueous Medium and in Bacterial Cells, Synthetic Route of 5738-14-7, the publication is Journal of the American Chemical Society (2011), 133(39), 15316-15319, database is CAplus and MEDLINE.

Bioorthogonal reactions suitable for functionalization of genetically or metabolically encoded alkynes, for example, copper-catalyzed azide-alkyne cycloaddition reaction (“click chem.”), have provided chem. tools to study biomol. dynamics and function in living systems. Despite its prominence in organic synthesis, copper-free Sonogashira cross-coupling reaction suitable for biol. applications has not been reported. In this work, the authors report the discovery of a robust aminopyrimidine-palladium(II) complex for copper-free Sonogashira cross-coupling that enables selective functionalization of a homopropargylglycine (HPG)-encoded ubiquitin protein in aqueous medium. A wide range of aromatic groups including fluorophores and fluorinated aromatic compounds can be readily introduced into the HPG-containing ubiquitin under mild conditions with good to excellent yields. The suitability of this reaction for functionalization of HPG-encoded ubiquitin in Escherichia coli was also demonstrated. The high efficiency of this new catalytic system should greatly enhance the utility of Sonogashira cross-coupling in bioorthogonal chem.

Journal of the American Chemical Society published new progress about 5738-14-7. 5738-14-7 belongs to pyrimidines, auxiliary class Pyrimidine,Amine,Alcohol,Pyrimidine, name is 2-(Dimethylamino)pyrimidine-4,6-diol, and the molecular formula is C6H9N3O2, Synthetic Route of 5738-14-7.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia