Category: 57473-32-2

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 57473-32-2, name is 5,7-Dichloroimidazo[1,2-a]pyrimidine, molecular formula is C6H3Cl2N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: pyrimidines

Example 6: S-^SR^RJ-S-CCT-Chloroimidazotl^-fllpyrimidin-S-yO^ethylJamino)^- methylpiperidin-l-yl)-3-oxopropanenitrile (47)47To a stirred solution of 5,7-dichloroimidazo[l,2-a]pyrimidine (46) (0.082 g, 0.43 mmol) in dioxane (2 niL) was added 3-((3R,4R)-4-methyl-3-(methylamino)piperidin-l-yl)-3- oxopropanenitrile (21) (0.10 g, 0.43 mmol), sodium hydrogen carbonate (0.036 g, 0.43 mmol) and water (2mL). The mixture was subjected microwave irradiation (100 C, Power Max, Power 50w) for 30 minutes. The reaction mixture was concentrated in vacuum and the residue obtained was purified by flash chromatography (silica gel 12 g, eluting with CMA-80 in chloroform 0 to 100%). The product obtained was repurifed by flash chromatography [silica gel 12 g, eluting with a mixture of ethyl acetate and methanol (9:1) in hexanes (0 to 100%)] to afford 3-((3R,4R)-3-((7- Chloroimidazo [ 1 ,2-alpha]pyrimidin-5-yl)(methyl)amino)-4-methylpiperidin- 1 -yl)-3 -oxopropanenitrile (47) (14 mg, 9.38%) as a colorless solid. 1HNMR (300 MHz, DMSO, 380K) delta 7.68 (d, J= 1.6, IH), 7.61 (d, J= 1.6, IH), 6.65 (s, IH), 3.93 (d, J= 5.1, 2H), 3.88 – 3.79 (m, 2H), 3.65 (dd, J= 8.3, 13.7, IH), 3.46 (d, J= 35.6, 2H), 3.00 (s, 3H), 2.32 (d, J= 6.9, IH), 1.80 – 1.58 (m, 2H), 1.03 (d, J= 7.0, 3H); MS (ES+): 347.1 (M + 1), 369.0 (M+23).Compound 46 is commercially available from Toronto Research Chemicals, or it can be prepared as described by, Revankar, Ganapathi R. et al., Journal of Medicinal Chemistry, 1975, 7S(12); or G. R. Revankar and R. K. Robins, Ann. KY. Acad. ScL, 1975, 255, 166.

With the rapid development of chemical substances, we look forward to future research findings about 57473-32-2.

Reference:
Patent; BIOCRYST PHARMACEUTICALS, INC.; BABU, Yarlagadda, S.; CHAND, Pooran; KOTIAN, Pravin, L.; KUMAR, V., Satish; WO2010/14930; (2010); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 57473-32-2, Adding some certain compound to certain chemical reactions, such as: 57473-32-2, name is 5,7-Dichloroimidazo[1,2-a]pyrimidine,molecular formula is C6H3Cl2N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 57473-32-2.

General procedure: Example 8. General Procedure H A mixture of the desired chloroimidazopyrimidines i-H (1 equiv), desired aminomethyl heterocycle or benzylamine ii-H (1.2 equiv), and triethylamine (NEt3) (1.5-3.5 equiv) in 1,4-dioxane (~0.1 M) was stirred at 70 C until the reaction was complete by LC-MS and/or TLC analysis. The crude reaction mixture was directly purified by silica gel chromatography (typical eluents included, for example, a mixture of hexanes and EtOAc, or a mixture of CH2Cl2 and MeOH, or an 80:18:2 mixture of CH2Cl2/CH3OH/concentrated NH4OH) to afford the desired product iii-H. The product structures prepared according to General Procedure H were confirmed by 1H NMR and/or by mass analysis.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 57473-32-2, 5,7-Dichloroimidazo[1,2-a]pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE GENERAL HOSPITAL CORPORATION; UNITED STATES DEPARTMENT OF HEALTH AND HUMAN SERVICES; SLAUGENHAUPT, Susan, A.; JOHNSON, Graham; PAQUETTE, William, D.; ZHANG, Wei; MARUGAN, Juan; (306 pag.)WO2016/115434; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 57473-32-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 57473-32-2, name is 5,7-Dichloroimidazo[1,2-a]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Example 8. General Procedure H A mixture of the desired chloroimidazopyrimidines i-H (1 equiv), desired aminomethyl heterocycle or benzylamine ii-H (1.2 equiv), and triethylamine (NEt3) (1.5-3.5 equiv) in 1,4-dioxane (~0.1 M) was stirred at 70 C until the reaction was complete by LC-MS and/or TLC analysis. The crude reaction mixture was directly purified by silica gel chromatography (typical eluents included, for example, a mixture of hexanes and EtOAc, or a mixture of CH2Cl2 and MeOH, or an 80:18:2 mixture of CH2Cl2/CH3OH/concentrated NH4OH) to afford the desired product iii-H. The product structures prepared according to General Procedure H were confirmed by 1H NMR and/or by mass analysis.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 57473-32-2, 5,7-Dichloroimidazo[1,2-a]pyrimidine.

Reference:
Patent; THE GENERAL HOSPITAL CORPORATION; UNITED STATES DEPARTMENT OF HEALTH AND HUMAN SERVICES; SLAUGENHAUPT, Susan, A.; JOHNSON, Graham; PAQUETTE, William, D.; ZHANG, Wei; MARUGAN, Juan; (306 pag.)WO2016/115434; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia