Application of 57473-33-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.57473-33-3, name is 7-Chloroimidazo[1,2-a]pyrimidin-5(1H)-one, molecular formula is C6H4ClN3O, molecular weight is 169.57, as common compound, the synthetic route is as follows.
Example 67-Chloro-l-(methylmvalate)imidazo[l,2-aJpyrimidin-5-one:To a suspension of 7-chloroimidazo[l,2-alpha]pyrimidin-5-one [for preparation see Annals of the New York Academy of Sciences. 1975, 255, 166-176] (600 mg, 3.54 mmol) in dry dimethylformarnide (20 mL) was added sodium hydride (60% in oil, 168 mg, 4.2 mmoles) at 20C and stirred for one hour. Chloromethyl pivalate (612 muL) was added and stirred at 20C for 16 hours. The reaction mixture was evaporated to dryness. The residue was purified on silica gel using dichloromethane/methanol (99/1) as eluant to give the title compound (710 mg) as a white powder.1H NMR (DMSO-d6) delta ppm: 1.15 (s, 9H, CH3), 6.04 (s, 2H, CH2), 6.11 (s, IH), 7.75 (syst AB, 2H, CH);Mass spectrum : m/z (FAB>0) 284 (M+H)+, 567 (2M+H)+.
The chemical industry reduces the impact on the environment during synthesis 57473-33-3, I believe this compound will play a more active role in future production and life.
Reference:
Patent; IDENIX (CAYMAN) LIMITED; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; UNIVERSITA DEGLI STUDI DI CAGLIARI; UNIVERSTITAT OSNABRUCK LABORATORIUM FUR ORGANIC AND BIORGANIC CHEMIE; WO2006/922; (2006); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia